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Plasma exchange cut vitamin D levels in half – June 2012


Abstract of poster presented at Vitamin D Workshop June 2012
T.F. Hiemstra, A. Casian, P. Boraks, D R. Jayne, I. Schoenmakcrs Department of Medicine, University of Cambridge, CB2 OQQ United Kingdom

Plasma exchange (PEX) is a widely used immune-modulating therapy for diseases mediated by antibodies or pathogenic proteins, or for transplant desensitisation. Vitamin D (25(OH)D) deficiency is associated with skeletal and extra-skeletal pathology, is permissive to activity of a number of autoimmune diseases, and may be associated with poorer renal allograft survival.

We asked whether PEX would induce vitamin D deficiency through removal of its carrier, the 56kDa vitamin D binding protein (DBP).

We performed a single-centre prospective cohort study of patients receiving plasma exchange at Addenbrooke's Hospital, Cambridge. Vitamin D metabolites, DBP and biochemical parameters were measured before the start and after every plasma exchange treatment, as well as 7 and 28 days after completion of PEX. 11 Caucasian European patients (7 males) aged 59 ± 13 years received 5.5 ± 0.9 PEX treatments, for ANCA-associated vasculitis (n=5), myasthenia gravis (n=3), paraneoplastic neuropathy (n=2) and voltage-gated potassium channel antibody-mediated encephalopathy (n=l). Baseline estimated glomerular filtration rate was 56.9 ± 39.5 ml/min/ 1.73m2, and 5 patients had chronic kidney disease stage 3 or worse.

Baseline 25(OH)D levels were 50.6 ± 30.1 nmol/L.

  • significantly reduced 25(OH)D levels after 5 treatments to 22 ± 9.4nmol/L (p = 0.0017), and vitamin D
  • remained low 7 days (26.4 ± 9.8nmol/L, p=0.02) and
  • 28 days (30.8 ± 15.5, p=0.048) after cessation of PEX.

la25(OH)2D3 levels reduced from 103 ± 52pmol/L to 42 ± 4pmol/L (p = 0.003) with PEX, but had returned to baseline levels after 7 days. PEX also significantly reduced DBP levels from 206.5 ± 64.7ug/mL to 98.5 ± 34u.g/mL (p = 0.0001), but levels had returned to baseline after 7 days.

PEX significantly reduced corrected Calcium from 2.23 ±0.12 mmol/L to 1.98 ± 0.08 mmol/L (p = 0.0007), but did not alter phosphate.

Analyses of plasma effluent confirmed removal of DBP, 25(OH)D and PTH by PEX.

In conclusion, we identified sustained reduction in 25(OH)D and acute reversible reduction in l,25(OH)2D3 by a typical course of PEX, likely through its removal with DBP in plasma effluent.

This vitamin D deficiency is likely to offset the benefit of PEX.

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Summary and comment by VitaminDWiki

It would appear that following a plasma exchange that a person needs to get restocked with vitamin D

  • 20 ng initially
  • 9 ng following 5 plasma exchanges
  • 11 ng after 7 days
  • 12 ng after 28 days

PLASMA EXCHANGE is used for (from WikiPedia)

Multiple sclerosis
Guillain-Barré syndrome
Chronic inflammatory demyelinating polyneuropathy
Goodpasture's syndrome
Hyperviscosity syndromes: Cryoglobulinemia, Paraproteinemia, Waldenström macroglobulinemia
Myasthenia gravis
Thrombotic thrombocytopenic purpura (TTP)/hemolytic uremic syndrome
Wegener's granulomatosis
Lambert-Eaton Syndrome
Antiphospholipid Antibody Syndrome (APS or APLS)
Microscopic polyangiitis
Recurrent focal and segmental glomerulosclerosis in the transplanted kidney
HELLP syndrome
PANDAS syndrome
Refsum disease
Behcet syndrome
HIV-related neuropathy
Graves' disease in infants and neonates
Pemphigus vulgaris
Toxic Epidermal Necrolysis (TEN)

See also VitaminDWiki

See also web

  • Plasmapheresis at CIDPUSA Aug 2012
    lots of details on plasma exchange - example: 300,000 PEX per year
    CIDP = Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Attached files

ID Name Comment Uploaded Size Downloads
1582 Plasma Exchange poster.pdf PDF admin 30 Aug, 2012 16:30 846.42 Kb 1414
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