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Pink eye (seasonal allergic conjunctivitis) associated with low vitamin D and high vitamin E – March 2014

Plasma vitamin D and serum total immunoglobulin E levels in patients with seasonal allergic conjunctivitis

Acta Ophthalmologica Scandinavica Foundation, Article first published online: 25 MAR 2014. DOI: 10.1111/aos.12398
Zeynep Dadaci 1,*, Mehmet Borazan 1, Aysel Kiyici 2 andNursen Oncel Acir 1
* Zeynep Dadaci, MD, Department of Ophthalmology, Mevlana (Rumi) University School of Medicine zdadaci at hotmail.com
.
Purpose: To evaluate plasma 25-hydroxyvitamin D and serum total immunoglobulin E (IgE) levels in patients with seasonal allergic conjunctivitis (SAC).

Methods
This observational case–control study involved 49 patients with SAC without any other ocular and systemic diseases, and 44 consecutive, age- and sex-matched healthy subjects. Plasma 25-hydroxyvitamin D and serum total IgE levels of all subjects were quantified with electrochemiluminescence technique. Results were compared between the groups, and p values of <0.05 were considered as statistically significant.

Results
No significant differences were found between the groups with respect to age (p = 0.41) and sex (p = 0.98).
Plasma vitamin D levels of the

  • subjects with SAC (*median 8.03 ng/ml, range 3.00–17.97 ng/ml) were significantly lower than the
  • control group (median 10.52 ng/ml, range 3.30–25.92 ng/ml) (p = 0.007).

Serum total IgE levels of

  • patients with SAC (median 48.65 IU/ml, range 1.77–812.00 IU/ml) were significantly higher when compared to the
  • control group (median 32.49 IU/ml, range 0.14–104.60 IU/ml) (p = 0.003).

Conclusions
We found lower plasma vitamin D levels and higher serum total IgE levels in patients with SAC.

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Allergic rhino-conjunctivitis associated with very low levels of vitamin D – March 2015

Plasma vitamin D levels of patients with allergic rhino-conjunctivitis with positive skin prick test.
Am J Rhinol Allergy. 2015 Mar;29(2):46-9. doi: 10.2500/ajra.2015.29.4164.
Yenigun A1, Dadaci Z, Oncel M.

VitaminDWiki Summary

42 patients, average age 26
Vitamin D level: 7 ng if ARC, 13 ng control group
The items in Autoimmune and Infant-Child D are listed here:


BACKGROUND:
Allergic rhino-conjunctivitis (ARC) and allergic rhinitis are inflammatory diseases that develop through immunoglobulin E in the rhino-ocular mucosa due to allergy. The main symptoms are runny nose, nasal congestion, sneezing, itchy nose, and conjunctivitis.

OBJECTIVE:
This study was designed to evaluate plasma 25-hydroxyvitamin D levels in patients with ARC.

STUDY DESIGN:
This study was planned as a prospective and cross sectional study. This study was performed in a tertiary referral center.

METHODS:
This observational study involved 42 patients with ARC and 35 consecutive, age- and sex-matched healthy subjects. Patients in both groups underwent skin-prick test. Plasma 25-hydroxyvitamin D levels of all subjects were quantified with electrochemiluminescence technique. Results were compared between the groups and p < 0.05 was considered as statistically significant.

RESULTS:
Group one included 42 ARC patients (15 male, 27 female, ages between 12 and 43, average age 25.7 ± 8.6); group two included 35 healthy people (15 male, 20 female, ages between 12 and 44, average age 26.9 ± 9.1). Plasma 25-hydroxyvitamin D levels of the subjects with ARC group (7.33 ± 3.61 ng/mL, standard error mean: 0.55, range 3.17-13.68 ng/mL) were significantly lower than the control group (13.37 ± 5.42 ng/mL, standard error mean: 0.91, range 6.84-25.92 ng/mL) (p = 0.010, Independent-Samples test).

CONCLUSIONS:
We found lower plasma vitamin D levels in patients with ARC when compared with the control group.

PMID: 25785742


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3734 SAC.jpg admin 26 Mar, 2014 13:56 59.33 Kb 2582
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