Gastroenterol Clin Biol. 2010 Aug 27.
Rode A, Fourlanos S, Nicoll A.
Department of Gastroenterology, Royal Melbourne Hospital, Grattan St, Parkville, VIC, 3050, Melbourne, Australia.
BACKGROUND & AIMS: End-stage chronic liver disease is associated with vitamin D deficiency but the prevalence across a broad-spectrum of liver disease is unknown.
This study prospectively examines prevalence of vitamin D deficiency and response to replacement in chronic liver disease.
METHODS: One hundred and fifty-eight outpatients with chronic liver disease were enrolled.
Serum 25-hydroxyvitamin D (25[OH]D) levels were classified as:
- severely deficient less than 25nmol/l, deficient 25-54nmol/l or
- replete greater than 54nmol/l.
Sixty-five of 158 (41%) had cirrhosis.
RESULTS: 25[OH]D was suboptimal in 101/158 (64%), including severe deficiency in 24 patients (15%).
Vitamin D deficiency occurred in liver disease of all aetiologies, including patients with only mild liver disease. 25[OH]D increased by 60.0% (19.11+/-13.20nmol/l) in patients with deficiency after vitamin D replacement and decreased by 25.2% (-18.33+/-12.02nmol/l) in non-treated initially replete patients over a median of 4 months.
CONCLUSIONS: Vitamin D deficiency improves with oral vitamin D supplementation and levels fall without supplementation.
Chronic liver disease patients are at very high risk of vitamin D deficiency regardless of etiology or severity. PMID: 20801590
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