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Opportunity to give 400 IU of vitamin D to children at risk of rickets

Vitamin Angels provide vitamins for needy children and women around the world, but only 200 IU

Vitamin Angels: We could reach 100 million kids tomorrow if we had the funding
Nice introduction at Nutraingredients, May 2013

Vitamin Angels home page
Biggest Contributors to Vitamin Angels

  • Cash $500,000+ Sams Club, Flintstone Vitamins, VitaminWater
  • Cash $100,000+ Pharmachem labs, Univera, Vitamin World, Barlean’s
  • Cash $50,000+ Nutragenetics, Purity Products, Vitamin Shoppe, TwinLab
  • Pills $5,000,000+ ProCaps Labs
  • Pills $1,000,000+ NBTY
  • Pills $250,000+ Capsugel

Vitamin Angels have 2 programs - both operated thru NGOs in the country

  • Operation 20/20 which gives vitamin A twice a year
  • Thrive to five which gives multivitamins on a daily basis to only:
    Infants 6 months – 5 years (No vitamins for age 0-6 months)
    Pregnant or lactating mothers

The Vitamin Angels base their supplements on old recommendations from WHO/UNICEF published in 2006.
PDF is attached at the bottom of this page Which has the following graphic
Image
WHO probably goes for the lowest common denominator, example: UK is still just recommending 200 IU of vitamin D

Problems with low vitamin D

  • Only 200 IU for Pregnant and lactating Women
  • Only 200 IU for children age 6 months to 5 years
    Which is not enough to even stop rickets (Turkey reduced rickets by 60X with 400 IU)
  • No vitamins for age 0-6 months
    Suspect because infants cannot eat solids, such as pills, until 6 months
    Suspect that the liquid form of vitamin D became available after WHO recommendation
    Infants 0-6 months REQUIRE vitamin D and extremely rarely get it thru breast milk now

WHO is still using the old (1997) recommendations of the Institute of Medicine

Image

Rather than the updated 2010 recommendations
Image
where 0-1 year Adequate Intake is 400 IU of Vitamin D


Vitamin D intervention Opportunity

WHO does not mention any supplementation for infants until they can take sold foods – at age 6 months.
WHO recommends a bare minimum of vitamin D, 200 IU starting at age 6 months
The incidence of rickets in several countries around the world ranges from 10% to 70% of all infants
The cost of liquid vitamin D at retail prices is $15 for 90 days of 400 IU drops
So retail price of 400 IU daily for first 6 months of life is $30
Assume that the wholesale price would be $15
Assume that need to treat 5 infants to stop tickets in countries with lots of rickets (20%)

Thus the wholesale cost of vitamin D would be 5 X $15 = $75 to prevent 1 child from getting rickets

Example:

  • After Turkey GAVE 400 IU of vitamin D to all infants, rickets fell from a rate of 6% to 0.1%, a 60X reduction
    Note: This was without any additional Calcium or nutrition.
  • Mongolia: 60,000 births/year X $15 = $900,000/year to stop rickets in Mongolia

Notes

  • Vitamin D is the highest cause of rickets, but not the only – lack of Calcium /Phosphrosis
  • Expect that after stopping vitamin D at age 6 months that the body’s levels will remain high for a few more months.
  • Wonder the % of rickets which can be eliminated with starting 200 IU of vitamin D at age 6 months?
  • In addition to rickets 75 percent of unexplained sudden infant deaths had inadequate level of vitamin D – April 2013
    • another study found that 87% of the SIDS babies <1 year showed evidence of rickets
  • Need to check assumption: That giving 400 IU of vitamin D daily for 6 months will be enough to stop rickets at later age.

Opportunity steps

  1. Get wealthy people from Mongolia, etc to donate funds to give vitamin D to those children.
  2. Convience Vitamin Angels to provide vitamin D at ages 0-6 months (increases their impact)
  3. Convience Vitamin Angels to direct funds donated for liquid vitamin D to specific countries or high risk infants

Notes

  • Most of the countries with lots of rickets have poor health.in other ways as well
    They have adapted to overall poor health, so may not easily change
  • Normalizing vitamin D so as to virtually eliminate rickets will probably also decrease other vitamin D deficiency diseases, such as TB and pneunomia
  • Need to give vitamin D to ALL of the infants, not just those who are members of poor families
    Note the experience of Turkey, which needed to give to ALL infants to achieve a national 60X decrease in rickets

Slides about Rickets from Vitamin D Workshop in San Francisco, June 2013

From: The Prevention of Vitamin D Deficiency at the Community Level - Zulf Mughai, Manchester, UK


Workshop2013-004.jpg Workshop2013-001.jpg Workshop2013-002.jpg Workshop2013-003.jpg

From slide: Mongolia 70%, Tibet 66%, Ethiopia 42%, Yemen 27%, Turkey 10% (reduced to 0.1% after providing 400 IU to all infants), Nigeria 9%


Searched for wealthy people in various countries with high rate of rickets

(wealthiest OR richest OR Rich) (mongolia OR tibet OR ethiopia OR Yemen OR Nigeria )

Found http://www.celebritynetworth.com/
The Black Billionaires Forbes, March 2013

http://en.wikipedia.org/wiki/List_of_countries_by_the_number_of_billionaires

Mongolia

Rickets PDF is attached at the bottom of this page
Image
http://mayaguais.blogspot.com/2013/05/mongolias-10-richest-men.html
Mongolia's 10 richest men May 2013
Two Brothers Conquer Mongolia's Free-Market Wild West
l Mongolia $1.25/Day Labor Amid $4K Purses Stirs Discontent

Yemen

http://www.ethiopianreview.com/content/35441
Top 20 Richest Ethiopians – 2011
Ethiopia 82 million population, 2.6 million births per year
Very poor health – so they are used to it
Among the top TB rates in the world – also might be helped with vitamin D
childhood pneumonia – also might be helped with vitamin D


Image Image

http://en.wikipedia.org/wiki/Mohammed_Hussein_Al_Amoudi
Forbes has estimated his net worth at $12.3 billion, making him the 63rd richest person in the world.
This listing also ranks him as the richest person in Ethiopia and the second richest Saudi Arabian citizen in the world
As of March 2013, Forbes ranked Al Amoudi as the second richest black person in the world
See Overview Dark Skin and Vitamin D) and ((Dark skin births are much riskier due to lack of vitamin D

Al-Amoudi is a philanthropist and has committed funds to support healthcare and sport in Saudi Arabia, the US, Europe and Africa.
He has funded a breast cancer research centre at King Abdulaziz University.

In 2008, Al Amoudi funded King Saud University’s an enhanced oil recovery research chair.
The Sheikh has also fully funded the King Abdullah Institute for Nanotechnology at King Saud University.

Nigeria

The Top 50 Richest Nigerian Billionaires

Middle East and low Vitamin D

Vitamin D deficiency in Middle East and North Africa - June 2013 in VitaminDWiki - a few point follow
These include a prevalence of 27% in children < 5 y in North Yemen, 10% in a field sample from rural Egypt, 1% Kuwait if < 2yrs (1981−86), 0.5% of Saudis < 2 y (1997–1999) and 6% in Turkey in 1998 down to < 1% in 2008, the latter following a National Vitamin D supplementation program.11

Rickets accounted for a substantial number of pediatric hospital admissions, 50% of children hospitalized with pneumonia in Yemen, 11% of infant’s admissions with acute illness in Jordan, 6.5% of newborn admissions in Kuwait and 1.8% of pediatric admissions in 1986–88 in Saudi Arabia.9,11 Non-skeletal manifestations of rickets included convulsions in 4−79% of patients, acute chest infections and asthmatic bronchitis in 66% of 500 cases in Saudi Arabia, broncho-pneumonia in 43% of 200 Iranian children and 44% of 250 children from Kuwait. An acute infection or respiratory diseases were the presenting manifestation in 20–60% of cases presenting with rickets in smaller studies from Turkey, Egypt, Jordan and Saudi Arabia, while gastroenteritis accounted for 8–56% of reasons for admission in hospitals in Middle East. Dilated cardiomyopathy was reported in three infants from Asia, one from Turkey and two from UAE.11 Predictors of rickets included, low maternal vitamin D status, prolonged breast feeding, low socioeconomic status (SES), educational level and crowding. It has been recognized that primary vitamin D deficiency does not adequately describe nutritional rickets explained in some African, Middle Eastern and Asian countries and that concomitant low calcium intake and possibly disturbances of phosphate metabolism, renal compromise and iron deficiency may also play an important role in the pathophysiology of the disease.9

Note: Amount of vitamin D to infants drops drastically after breastfeeding/formula feeding has stopped.


See also VitaminDWiki - Rickets

See also VitaminDWiki - infants

See also VitaminDWiki - pregnancy

PDF is attached at the bottom of this page http://is.gd/D6months

Attached files

ID Name Comment Uploaded Size Downloads
2736 IoM Children.jpg admin 05 Jul, 2013 23:46 25.16 Kb 2760
2735 Adequate Intake IoM 1997.jpg admin 05 Jul, 2013 23:45 43.72 Kb 4793
2650 al-amoudi.jpg admin 25 Jun, 2013 18:16 6.12 Kb 1465
2649 mohammed-al-amoudi.jpg admin 25 Jun, 2013 18:16 17.67 Kb 1861
2587 Rachitic signs - Mongolia 1992.jpg admin 19 Jun, 2013 13:50 23.79 Kb 1677
2586 Human_nutrition_in_Mongolia_S_Strickland.pdf PDF admin 19 Jun, 2013 13:49 1.03 Mb 708
2542 Vit Angels content.jpg admin 02 Jun, 2013 14:09 37.61 Kb 3947
2541 WHO UNICEF 2006.pdf PDF admin 02 Jun, 2013 14:09 782.07 Kb 579
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