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One autoimmune disease lowers vitamin D, a second AI disease does not lower it further – Jan 2015

Vitamin D and autoimmunity: what happens in autoimmune polyendocrine syndromes?

Journal of Endocrinological Investigation, January 2015
G. Bellastella giuseppe.bellastella at unina2.it , M. I. Maiorino, M. Petrizzo, A. De Bellis, A. Capuano, K. Esposito, D. Giugliano
1. Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Second University of Naples, Piazza L. Miraglia 2, 80138, Naples, Italy
2. IOS and Coleman Medicina Futura Medical Center, Centro Direzionale, Naples, Italy
3. Department of Cardio-Thoracic and Respiratory Sciences, Second University of Naples, Naples, Italy
4. Department of Experimental Medicine, Second University of Naples, Naples, Italy
5. Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy

VitaminDWiki Observation

After one disease empties the vitamin D bucket there is nothing left to empty by another disease

If you have such a low level of vitamin D as to have a disease you should restore the level so as to not get another disease associated with low vitamin D

To evaluate the Vitamin D status of patients with a single autoimmune disease and of patients with several autoimmune diseases.

We enrolled 35 patients with isolated type 1 diabetes mellitus (T1DM), 60 with autoimmune polyendocrine syndromes (APS) including T1DM and 72 control subjects. Among patients with APS, 10 were classified as type 2 (Addison’s disease + T1DM), whereas the other 50 as type 3 (autoimmune thyroid disease + T1DM + other autoimmune diseases). Vitamin D (25-OHD) levels were assessed by a chemiluminescent immunoassay in all patients and controls on samples drawn in the morning of the same months.

Both groups of APS and T1DM patients showed 25-OHD levels significantly lower than healthy controls (p < 0.001 for both vs controls), without any significant difference between the two groups (p = 0.80). The highest prevalence of vitamin D deficiency (values <20 ng/ml) was observed in APS type 3 subgroup (8 out of 50 patients, 16 %).

Patients with APS present reduced vitamin D circulating levels, but the vitamin D status is not different between patients with single or multiple autoimmune diseases. The kind of autoimmune disease, rather than the association of several autoimmune diseases, may influence negatively the levels of vitamin D. Further prospective studies are needed to clarify if impaired vitamin D level is a causal factor in the pathogenesis of autoimmune diseases or a consequence of them.

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  1. Yang CY, Leung PS, Adamopoulos IE, Gershwin ME (2013) The implication of vitamin D and autoimmunity: a comprehensive review. Clin Rev Allerg Immunol 45:217–226 CrossRef
  2. Pludowski P, Holick MF, Pilz S et al (2013) Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality––a review of recent evidence. Autoimmun Rev 12:976–989 CrossRef
  3. Prietl B, Treiber G, Pieber TR, Amrein K (2013) Vitamin D and immune function. Nutrients 5:2502–2521 CrossRef
  4. Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP (2004) Genetics and biology of vitamin D receptor polymorphism. Gene 338:143–156 CrossRef
  5. Bhalla AK, Amento EP, Clemens TL, Holick MF, Krane SM (1983) Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J Clin Endocrinol Metab 57:1308–1310 CrossRef
  6. Provvedini DM, Tsoukas CD, Detos LJ, Manolagas SC (1983) 1,25-dihydroxyvitamin D3 receptors in human leukocytes. Science 221:1181–1183 CrossRef
  7. Veldman CM, Cantorna MT, De Luca HF (2000) Expression of 1,25 dihydroxyvitamin D (3) receptor in the immune system. Arch Biochem Biophys 374:334–338 CrossRef
  8. De Luca HF, Cantorna MT (2001) Vitamin D: its role and uses in immunology. FASEB J 15:2579–2585 CrossRef
  9. Daniel C, Sartory NA, Zahn N, Radeke HH, Stein JM (2008) Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile. J Pharmacol Exp Ther 324:23–33 CrossRef
  10. Saggese G, Federico G, Balestri M, Toniolo A (1989) Calcitriol inhibits the PHA-induced production of IL-2 and IFN-gamma and the proliferation of human peripheral blood leukocytes while enhancing the surface expression of HLA class II molecules. J Endocrinol Invest 12:329–335 CrossRef
  11. Wu S, Cantorna MT (2008) The vitamin D receptor is required for iNKT cell development. Proc Nat Acad Sci USA 105:5207–5212 CrossRef
  12. Tamer G, Arik S, Tamer I, Coksert D (2011) Relative vitamin D insufficiency in Hashimoto’s thyroiditis. Thyroid 21:891–896 CrossRef
  13. Camurdan OM, Doger E, Bideci A, Celik N, Cinaz P (2012) Vitamin D status in children with Hashimoto thyroiditis. J Pediatr Endocrinol Metab 25:467–470 CrossRef
  14. Ramos Lopez E, Zwermann O, Segni M et al (2004) A promoter polymorphism of the CYP 27B1 gene is associated with Addison’s disease, Hashimoto’s thyroiditis, Graves’ disease and type 1 diabetes mellitus in Germans. Eur J Endocrinol 151:193–197 CrossRef
  15. Bozkurt NC, Karbek B, Ucan B et al (2013) The association between severity of vitamin D deficiency and Hashimoto’s thyroiditis. Endocr Pract 19:479–484 CrossRef
  16. Ramogopalan SV, Goldacre R, Disanto G, Giovannoni G, Goldacre MJ (2013) Hospital admission for vitamin D related conditions and subsequent immune-mediated disease: record-linkage study. BMC Med 11:171 CrossRef
  17. Balla B, Tobiás B, Kósa JP et al (2014) Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer. J Endocrinol Invest. doi:10.1007/s40618-014-0165-7
  18. Feng M, Li H, Chen SF, Li WF, Zhang FB (2013) Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Endocrine 43:318–326 CrossRef

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