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Omega-3 reduced by 4X the interruption of Cervical Cancer chemotherapy due to toxicity – RCT June 2019

Efficacy of omega-3 supplementation on nutritional status, skeletal muscle and toxicity to chemoradiotherapy in cervical cancer patients: a randomized, triple-blind clinical trial conducted in a middle-income country

Nutrition, https://doi.org/10.1016/j.nut.2019.06.009


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"Dose-limiting toxicity (DLT) was defined as any serious adverse event which resulted in discontinuation, delayed treatment or the need for a chemotherapy dose reduction"

Background & Aims
Omega-3 supplementation has shown to favor the preservation of body weight and skeletal muscle (SM). The aim was to evaluate the efficacy of omega-3 supplementation on nutritional status (NS), SM quantity and quality; and toxicity for treatment of women with cervical cancer.

Randomized, triple-blinded, placebo-controlled clinical trial in women diagnosed with cervical cancer who underwent chemoradiotherapy between March 2016 and August 2017. The intervention group (IG) received 4 capsules with omega-3 (2.5g/day) and the control group (CG) received the same number of capsules, identical, with olive oil, for 45 days. NS was measured by anthropometry and Patient-Generated Subjective Global Assessment (PG-SGA). Body composition was assessed by computed tomography. The skeletal muscle index (SMI) was calculated using the range -29 to +150 Hounsfield Units (HU). For SM quality, the area comprised between -29 to +29HU was denominated low-radiodensity skeletal muscle index (LRSMI) and the range between +30 to +150HU high-radiodensity skeletal muscle index (HRSMI), representing the SM area with high or low intramuscular fat infiltration, respectively.

The study population comprised 40 patients, with an average age 44.53 ± 8.73. IG maintained body weight and showed an improvement in PG-SGA score. A significant reduction in SMI was observed in both groups. However, in regard to SM quality, IG patients preserved LRSMI and HRSMI, while GC gained LRSMI and significantly reduced HRSMI, reflecting high intramuscular fat infiltration only in the CG. The incidence of chemotherapy toxicity was significantly lower in IG.

The results suggest that omega-3 supplementation is effective in maintaining NS, SM quality and reduced symptoms of chemoradiotherapy among women with cervical cancer.

Created by admin. Last Modification: Tuesday June 18, 2019 16:36:45 GMT-0000 by admin. (Version 6)

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