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Omega-3 index replaces the Omega-6 to Omega-3 ratio – March 2018

The Omega-6:Omega-3 ratio: A critical appraisal and possible successor

Prostaglandins, Leukotrienes and Essential Fatty Acids, 20 March 2018, https://doi.org/10.1016/j.plefa.2018.03.003
William S.Harris


  • Polyunsaturated fatty acid blood levels have predictive power for disease outcomes.
  • Both the Omega-3 Index and the n6:n3 ratio have been used to express PUFA status.
  • The n6:n3 ratio has become scientifically out-dated.
  • The Omega-3 Index, because if included EPA and DHA only, is a preferred metric.

The well-known health effects of the long-chain, marine omega-3 (n-3) fatty acids (FAs) has led to a growing interest in the prognostic value that blood levels of these FAs might have vis-à-vis cardiovascular and neurocognitive diseases. The measurement and expression of n-3 FA levels is not straight-forward, however, and a wide variety of means of expression of n-3 FA status have been used in research and clinical medicine. This has led to considerable confusion as to what “optimal” n-3 FA status is. The n-6:n-3 ratio has enjoyed relatively widespread use, but this apparently simple metric has both theoretical and practical difficulties that have contributed to misunderstandings in this field. Just as the once-popular polyunsaturated:saturated FA ratio has largely disappeared from the nutritional and medical literature, it may be time to replace the n-6:n-3 ratio with a newer metric that focuses on the primary deficiency in Western diets – the lack of eicosapentaenoic and docosahexaenoic acids (EPA and DHA). The Omega-3 Index (red blood cell EPA+DHA) has much to recommend it in this regard.
 Download the PDF from Sci-Hub via VitaminDWiki

VitaminDWiki notes

Note: Omega-3 Index cannot get very high (>7) if there is too much Omega-6
Note: Current target for Omega-3 = 8. Japan considers target= 10

Vitamin D and Omega-3 category starts with

394 Omega-3 items in category Omega-3 helps with: Autism (8 studies), Depression (29 studies), Cardiovascular (34 studies), Cognition (49 studies), Pregnancy (40 studies), Infant (32 studies), Obesity (13 studies), Mortality (7 studies), Breast Cancer (5 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (18 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etc
CIlck here for details

14+ VitaminDWiki pages with OMEGA-6 in the title

This list is automatically updated

Items found: 17
Title Modified
Hypothesis – Bipolar Disorder will be reduced if add Omega-3 while reducing Omega-6 – Oct 2016 06 Dec, 2023
Lecithin increased Omega-3 and decreased Omega-6 (in rats) - July 2016 17 Jul, 2023
Omega-6 blocks Omega-3 etc. -many studies 17 Jul, 2023
Omega-6 increase may have increased the risk of many other diseases - Jan 2022 05 Feb, 2022
Omega-3 did not prevent depression (they failed to reduce Omega-6, which blocks Omega-3) – RCT Dec 2021 22 Dec, 2021
High-dose Omega-3 fought COVID in 2 hospital trials (6x reduction in ICU, reduced time) – Masterjohn Oct 2021 14 Oct, 2021
4X fewer COVID-19 deaths in those having high Omega-3 index – Jan 6, 2021 13 Jan, 2021
Omega-3 index of 6 to 7 associated with best cognition in this study – Nov 2019 10 Nov, 2019
Prenatal Omega-3 somewhat reduced child allergies (should also reduce Omega-6) – RCT June 2018 17 Apr, 2019
Omega-3 index replaces the Omega-6 to Omega-3 ratio – March 2018 16 Apr, 2018
Why Alzheimer’s studies using Omega-3 have mixed results – quality, dose size, Omega-6, genes, etc. March 2018 18 Mar, 2018
People felt less aggression after just 6 weeks of Omega-3 – RCT Dec 2017 03 Mar, 2018
Supplementation while pregnant and psychotic – 20 percent Omega-3, 6 percent Vitamin D – June 2016 20 Jan, 2018
Hypothesis – Omega-6 to Omega-3 ratio increases obesity – Nov 2015 23 Oct, 2016
ADHD 2 times more likely if poor Omega-6 to Omega-3 ratio – meta-analysis May 2016 07 Jun, 2016
Huge increases in Omega-6 to Omega-3 ratio increase risk of obesity, etc. – March 2016 14 Mar, 2016
Schizophrenia treated by 6 months of Omega-3 – RCT Nov 2015 28 Nov, 2015

Created by admin. Last Modification: Monday July 17, 2023 23:25:46 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
9708 O-3 Index vs ratio.jpg admin 16 Apr, 2018 17.32 Kb 1341
9707 Omega-3 Index.pdf admin 16 Apr, 2018 938.96 Kb 548