Am J Psychiatry. 2018 Mar 21:appiajp201817070836. doi: 10.1176/appi.ajp.2018.17070836. [Epub ahead of print]
Freedman R1, Hunter SK1, Hoffman MC1.
From the Institute for Children's Mental Disorders and the Departments of Psychiatry and of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora.
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- 44X increase in Bipolar Disorder in youth in a decade – Sept 2007
- Vitamin D appears, from other studies, to both prevent and treat a variety of mental illnesses
- Some supplements seem to increase a few problems while decreasing others
Overview Schizophrenia and Vitamin D contains the following summary
Many reasons to think that schizophrenia is associated with low vitamin D
1) 97% of patients with schizophrenia are vitamin D deficient
2) Schizophrenia varies with latitude (UVB) by 10X (controversy)
3) Schizophrenia is more common in those with dark skin (when away from the equator)
4) Schizophrenia is associated with low natal vitamin D
5) Schizophrenia has been increasing around the world when vitamin D has been decreasing (controversy)
6) Schizophrenia is associated with low birth rate, which is associated with low vitamin D
7) Schizophrenia is associated with Autism which is associated with low vitamin D
8) Schizophrenia Bulletin Editorial (Jan 2014) speculated that Vitamin D could be a major player
9) Schizophrenia 2X more likely if low vitamin D - meta-analysis
10) Schizophrenia increased 40 % for Spring births after Danes stopped vitamin D fortification
11) Schizophrenia is associated with season of birth
12) Schizophrenia is associated with poor Vitamin D Receptor genes
13) Schizophrenia risk is decreased if give Vitamin D after birth
14) Schizophrenia symptoms reduced when Vitamin D levels are restored
Autism treated by Vitamin D: Dr. Cannell - video June 2013 includes many reasons why he believes Autism is related to Vitamin D
- Both have strong inheritance features – Vitamin D about 60%
- Both have gotten substantially worse in last 30 years
- Vitamin D is known to be involved in brain development
- All autistic children are VitD deficient, but not all children who are deficient are autistic: genes are involved
- When giving vitamin D to cure children of rickets “mental dullness” decreases as well
- Children with genes which give them too much (Williams Syndrome) have to reverse of autism – too sociable
- Mothers having lots of fish (and thus more vitamin D) give birth to kids with less autistic symptoms
- Both associated with weak bones
- Both worse around the age of weaning
- Autism is more common in rich families – more likely to apply sun screen and stay indoors
- Autism increases with drugs which lower levels of vitamin D
- Seizures are common with Autism - Vitamin D has been shown to reduce seizures
- Fewer autistic symptoms (such as sleep problems) during summer: when child gets more vitamin D from the sun
- Both worse with latitude
- Both vary with Ultraviolet light
- Both vary with time of year (more birth of autistics in March in Northern hemisphere)
- 2X more urban autism – less UVB in urban environments
- Both worse with pollution
- Both worse with increased clouds and rain
- Both worse with closely spaced pregnancies
- Autistics have abnormal immune response – similar to that of vitamin D deficiency
- Low levels of vitamin D in mother animals reduces brain function in offspring
- Vitamin deficient rat pups have similar brain abnormalities to that of human autistic children
- Autistic children get less vitamin D in their blood for the same amount of sun exposure
- The 4 males/1 female ratio - Note estrogen increases vitamin D in the brain (testosterone does not)
- Both worse in African Americans (A-A 2-3 increased autism rate)
- Both worse in Dark-skinned immigrants in Europe
- Note: All articles in Autism category
Genes, infection, malnutrition, and other factors affecting fetal brain development are a major component of risk for a child's emotional development and later mental illnesses, including schizophrenia, bipolar disorder, and autism. Prenatal interventions to ameliorate that risk have yet to be established for clinical use. A systematic review of prenatal nutrients and childhood emotional development and later mental illness was performed.
Randomized trials of folic acid, phosphatidylcholine, and omega-3 fatty acid supplements assess effects of doses beyond those adequate to remedy deficiencies to promote normal fetal development despite genetic and environmental risks. Folic acid to prevent neural tube defects is an example. Vitamins A and D are currently recommended at maximum levels, but women's incomplete compliance permits observational studies of their effects.
Folic acid and phosphatidylcholine supplements have shown evidence for improving childhood emotional development associated with later mental illnesses.
Vitamins A and D decreased the risk for schizophrenia and autism in retrospective observations.
Omega-3 fatty acid supplementation during early pregnancy increased the risk for schizophrenia and increased symptoms of attention deficit hyperactivity disorder, but in later pregnancy it decreased childhood wheezing and premature birth.
Studies are complicated by the length of time between birth and the emergence of mental illnesses like schizophrenia, compared with anomalies like facial clefts identified at birth. As part of comprehensive maternal and fetal care, prenatal nutrient interventions should be further considered as uniquely effective first steps in decreasing risk for future psychiatric and other illnesses in newborn children.
PMID: 29558816 DOI: 10.1176/appi.ajp.2018.17070836Omega-3, Vitamin D, Folic acid etc. during pregnancy and subsequent mental illness of child – March 2018
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