Bought and tested several nanoemulsions
Note: The following studies compare oral nano vs oil-based vitamin D
I do not recall a study of topical, sublingual or buccal Vitamin D
that skips the stomach, intestine, liver, and kidneys
- Vitamin D nanoemulsions 3.9X more bioavailable than Vitamin D micelles – Feb 2018
- Nanoemulsion vitamin D 40% more bio-available than fat-soluble - RCT Jan 2023
- Nanoemulsion 36% more bioavailable than fat soluble forms (single 60,000 IU dose) - Dec 2019
- Current Update on Nanoemulsion A Review - Jan 2021
- CoVID19 VitD and Nanotechnology Review EJBPS ; Jan 2020 BioTech
- Nanoemulsions for health, food, and cosmetics
- Advances in edible nanoemulsions - Digestion, bioavailability, and potential toxicity
- Nanoemulsions SciHub 2020
- Nanoemulsions - The rising star of antiviral therapeutics
- Nanoemulsions: An emerging platform for increasing the efficacy of nutraceuticals in foods
- 19+ VitaminDWiki pages with NANOEMULSION or EMULSION etc. in the title
- See also in VitaminDWiki
- There have been
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Vitamin D nanoemulsions 3.9X more bioavailable than Vitamin D micelles – Feb 2018
The Efficacy of Nanoemulsion-Based Delivery to Improve Vitamin D Absorption: Comparison of In Vitro and In Vivo Studies
Comparative Study Mol Nutr Food Res 2018 Feb;62(4). doi: 10.1002/mnfr.201700836
Alagu Selvi Kadappan 1, Chi Guo 1 2, Cansu E Gumus 3 4, Amy Bessey 1, Richard J Wood 1, David J McClements 3, Zhenhua Liu 1 5Nanoemulsions result in more uniform response than other forms
Scope: Vitamin D (VD) is a fat-soluble vitamin that has a wide range of skeletal and non-skeletal functions. Although it can be synthesized through sun exposure and obtained from fortified foods, VD inadequacy is epidemic worldwide. Therefore innovative strategies are necessary for improving VD status. The present study examined VD absorption via nanoscale delivery systems.
Methods and results: We examine the physical characteristics and in vitro bioaccessibility of cholecalciferol (VD3 ) in nanoemulsion using a simulated gastrointestinal tract system. To evaluate the in vivo bioavailability, we orally administer three groups of mice with VD3 nanoemulsion, VD3 coarse emulsion, or vehicle nanoemulsion without VD3 , and the serum 25(OH)D3 is measured using radioactive immunoassay. The nanoemulsion-based delivery system increases the in vitro bioaccessibility by 3.94-folds (p < 0.05), as indicated by the concentration of vitamin D3 in micelles. Our animal study shows that, when compared to the vehicle group, the coarse emulsion numerically increases the serum 25(OH)D3 by 36%, whereas the nanoemulsion statistically significantly increases the serum 25(OH)D3 by 73% (p < 0.01).
Conclusion: Our findings indicate that a nanoemulsion-based delivery system is a promising approach to improve VD bioavailability, and further studies are warranted to determine its efficacy in humans.
Download the SciHub PDF from VitaminDWikiStudy was cited 74 times as of Sept 2024
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Nanoemulsion vitamin D 40% more bio-available than fat-soluble - RCT Jan 2023
An open-label, randomized, crossover study to evaluate the bioavailability of nanoemulsion versus conventional fat-soluble formulation of cholecalciferol in healthy participants
Journal of Orthopaedics Volume 35, January 2023, Pages 64-68 https://doi.org/10.1016/j.jor.2022.10.017
Raman Kumar Marwaha a, Manish Verma b 1, Ajit Walekar c, Rakesh Sonawane b 2, Chirag Trivedi c
Background
Nanoemulsion preparations of cholecalciferol available in the market claim to have better bioavailability than the conventional fat-soluble cholecalciferol. However, limited data are available in humans for such preparations. We, therefore, compared the relative bioavailability of two formulations of 60,000 IU cholecalciferol (nanoemulsion oral solution, water-miscible vitamin D3 [test] vs soft gelatin capsules [reference]) in healthy adult participants.Methods
In this randomized, open-label, two-sequence, single-dose, two-way crossover study (CTRI/2018/05/013839), Indian participants aged 18–45 years received single dose of nanoemulsion and capsule formulations, under fasting conditions. Blood samples collected over 120 h were assessed to determine cholecalciferol concentrations. Pharmacokinetic parameters (area under the concentration-time curve up to 120 h [AUC0–120h], maximum observed drug concentration [Cmax], time to reach maximum drug concentration [Tmax], terminal half-life [T½el], and terminal elimination rate constant Kel) were estimated using baseline corrected data and analyzed using analysis of variance.Results
Among the 24 eligible participants, the relative bioavailability of nanoemulsion was significantly higher than the capsules by 36% (p = 0.0001) based on AUC0–120h. Similarly, Cmax of the nanoemulsion was significantly higher by 43% (p = 0.0001) than that of the capsules. The intra-participant variability for AUC0–120h and Cmax were 23.22% and 26.51%, respectively. The Tmax, T½el, and Kel were comparable for both the formulations. No adverse effects were noted with either of the two formulations.Conclusions
Nanoemulsion oral solution of cholecalciferol showed a greater bioavailability compared with soft gelatin capsules, under fasting conditions, in healthy human participants.
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Nanoemulsion 36% more bioavailable than fat soluble forms (single 60,000 IU dose) - Dec 2019
Bioavailability of nanoemulsion formulations vs conventional fat soluble preparations of cholecalciferol (D3) – An overview
J. of Clinical Orthopaedics & Trauma Nov–Dec 2019, pg 1094-1096 https://doi.org/10.1016/j.jcot.2019.07.014
Raman Kumar Marwaha a, Aashima Dabas bVitamin D deficiency is recognized as a pandemic affecting all ages and strata of population. The endogenous cutaneous synthesis of vitamin D is insufficient to maintain normal body requirement which necessitates the need for vitamin D supplementation or food-fortification. Conventional fat-soluble preparations of vitamin D have been traditionally used for prevention and therapeutic purposes. Recent advances in technology have enabled delivery of vitamin D through nanoemulsion formulations which ensure higher absorption and drug delivery. The following review briefly discusses the issues of bioavailability of nanoemulsion preparation of vitamin D vis-a-vis conventional fat soluble preparations.
Download the PDF from VitaminDWikiClipped from PDF
"...a single oral dose of 60,000 IU in healthy participants. The results showed that relative bioavailability in terms of serum levels of cholecalciferol following supplementation with nano preparation of vitamin D3 was significantly higher than fat-soluble D3 by 36%(P ¼ 0.001) based on AUC 0-120. "
Clipped from PDF
The nanoemulsions are considered superior to conventional vitamin D preparations for the following reasons:- a) It has greater therapeutic role in patients with malabsorption syndromes due to
- Inflammatory bowel disease,
- Celiac disease,
- Short bowel syndrome,
- Hepatobiliary disorders,
- Pancreatic insufficiency and
- Bariatric surgery who suffer from a deficiency of essential fatty acids and fat-soluble vitamins including vitamin D,
- b) Better compliance as it can be taken directly or with water/juice etc.
- c) Vitamin D nanoemulsions may also have also greater hepato-protective effect against high-fat diet-induced liver injury as observed in rats compared to conventional oral vitamin D preparations.
Current Update on Nanoemulsion A Review - Jan 2021
CoVID19 VitD and Nanotechnology Review EJBPS ; Jan 2020 BioTech
Nanoemulsions for health, food, and cosmetics
Advances in edible nanoemulsions - Digestion, bioavailability, and potential toxicity
Nanoemulsions SciHub 2020
Nanoemulsions - The rising star of antiviral therapeutics
Nanoemulsions: An emerging platform for increasing the efficacy of nutraceuticals in foods
19+ VitaminDWiki pages with NANOEMULSION or EMULSION etc. in the title
This list is automatically updated
Items found: 21
See also in VitaminDWiki
- Inhaled Vitamin D diluted nanoemulsion
- Nanoemulsion Vitamin D may be a substantially better form includes the following comparison
50,000 IU powder in capsule
Example Biotech PharmacalNanoemulsion
Example micro D3Average Cost
per day for 10,000 IU4 cents 8 cents IU per serving 50,000 IU = capsule 2,000 IU = drop Servings if want average
of 10,000 IU/day1 capsule
per 5 days25 drops = 1 /4 teaspoon
per 5 daysShelf life 1 year? 6 months? Add to food/drink Yes (powder) possiblly Apply to skin No Yes Swish in mouth
for fast responseYes if put powder in saliva
or swish vitamin D waterYes Gut-friendly perhaps probably Availability to cell
- better than bio-availabilitystandard perhaps 2X more
- due to small size
or activation of Vitamin D Receptor
There have been
7477 visits to this page Nanoemulsion Vitamin D is faster and better - many studies(Cached) Printer Friendly Follow this page for updates3856 visitors, last modified 01 Sep, 2024, This page is in the following categories (# of items in each category) - a) It has greater therapeutic role in patients with malabsorption syndromes due to
- There have been