Nat Rev Neurol. 2016 Dec 9. doi: 10.1038/nrneurol.2016.187. [Epub ahead of print]
Olsson T1, Barcellos LF2, Alfredsson L3.
1Neuroimmunology Unit, Center for Molecular Medicine, L8:04, Karolinska University Hospital (Solna), 17176 Stockholm, Sweden.
2Genetic Epidemiology and Genomics Laboratory, California Institute for Quantitative Biosciences (QB3), Office: 308D Stanley Hall, University of California, Berkeley, CA 94720-3220.
3Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden.
- Multiple Sclerosis risk factors – Vitamin D, parasites, and EBV – 2015
- Environmental risk factors for MS include latitude and vitamin D – Sept 2012
- Lack of sun and lack of vitamin D are both MS risk factors – Feb 2011
- Overview MS and vitamin D
MS updates from Brazil
- Treatment with daily high doses of vitamin D Overcoming MS May 2013
Of course, this is not a cure it's a life-long treatment.. but at least it stops the progression and in many cases even revert back some (sometimes all) of the brain lesions.
- Huge page - all in Portuguese about Coimbra's work
- Web site of patients who have been cured by Dr. Coimbra Australia 150 ng is the target
Great sequential posts, over a year. by an Australian patient whose MS was reversed by Dr. Coimbra
- I Have Multiple Sclerosis: I Am Treating My MS With High Doses Vitamin D experienceproject. May 2013
Gives a fair amount of details, such as taking lots of water and monitoriing for excess Calcium.
Note A home test kit for excess Calcium in the urine is available $10 for 10 tests
- Dr. Holick visited with the patients in Brazil Sept 2013
Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 contains protocol description
Vitamin D Protocol used by Dr. Coimbra for Multiple Sclerosis etc.
Snips as of April 2016 http://www.vitamindprotocol.com/dr.-coimbra-s-ms-protocol.html
- 1,000 IU's vitamin D per kilogram as a first approximation
(apparently increased/decreased depending of resulting vitamin D blood level)
- Vitamin B2, magnesium glycinate, boron, chromium picolinate, Omega 3 DHA, Zinc, Methylcobalamin form of B12, Choline, etc.
- Lack of B12 may affect 10%–15% of the general population and may be the most prevalent genetic risk factor for several human diseases
- Discontinue eating or drinking dairy products or calcium enriched foods or beverages, also no Ca supplements
- Drink as least 2.5 liters [85 ounces] of fluids, preferably water
- Required Tests: Vitamin D, Parathyroid, Blood calcium, urinary calcium
Genetic predisposition to multiple sclerosis (MS) only explains a fraction of the disease risk; lifestyle and environmental factors are key contributors to the risk of MS. Importantly, these nongenetic factors can influence pathogenetic pathways, and some of them can be modified. Besides established MS-associated risk factors –
- high latitude,
- female sex,
- low vitamin D levels
caused by insufficient sun exposure and/or dietary intake, and
- Epstein-Barr virus (EBV) infection
- strong evidence now supports obesity during adolescence as a factor increasing MS risk.
- Organic solvents and shift work have also been reported to confer increased risk of the disease,
whereas factors such as
- use of nicotine or alcohol,
- cytomegalovirus infection and a
- high coffee consumption
are associated with a reduced risk.
Certain factors - smoking, EBV infection and obesity - interact with HLA risk genes, pointing at a pathogenetic pathway involving adaptive immunity. All of the described risk factors for MS can influence adaptive and/or innate immunity, which is thought to be the main pathway modulated by MS risk alleles. Unlike genetic risk factors, many environmental and lifestyle factors can be modified, with potential for prevention, particularly for people at the greatest risk, such as relatives of individuals with MS. Here, we review recent data on environmental and lifestyle factors, with a focus on gene-environment interactions.
PMID: 27934854 DOI: 10.1038/nrneurol.2016.187