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Monthly vitamin D (120,000 IU) got most overweight African Americans about 35 ng – RCT July 2015

Dose and time responses of vitamin D biomarkers to monthly vitamin D 3 supplementation in overweight/obese African Americans with suboptimal vitamin d status: a placebo controlled randomized clinical trial

BMC Obesity 2015, 2:27 doi:10.1186/s40608-015-0056-2
Jigar Bhagatwala12, Haidong Zhu1, Samip J. Parikh12, De-Huang Guo1, Ishita Kotak1, Ying Huang1, Robyn Havens13, Michael Pham1, Eric Afari1, Susan Kim1, Christopher Cutler4, Norman K. Pollock1, Yutong Dong1, Anas Raed12 and Yanbin Dong1 ydong at gru.edu
1 Georgia Prevention Institute, Medical College of Georgia, Georgia Regents University, Building HS-1640, Augusta 30912-3715, GA, USA
2 Department of Internal Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA
3 College of Nursing, Georgia Regents University, Augusta, GA, USA
4 College of Dental Medicine, Georgia Regents University, Augusta, GA, USA

VitaminDWiki Comment
  • They could have used a loading dose to replete the Vitamin D levels in 1 week instead of 12 weeks
  • The 120,000 IU dose every 4 weeks is just a bit larger than the 50,000 IU dose every 2 weeks which VitaminDWiki recommends
  • The 120,000 IU dose was the only one to achieve a reduction in PTH levels
  • 30 day doses are OK, but not as effective as doses given < 19 days.

See also VitaminDWiki

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Abstract
Background
A critical need exists to better understand the physiological sequel of vitamin D supplementation in obese individuals and African Americans. The aim was to comprehensively evaluate dose- and time-responses of a panel of vitamin D biomarkers to vitamin D supplements in this population.

Methods
We conducted a 16-week randomized, double-blinded, and placebo-controlled clinical trial. Seventy overweight/obese African Americans (age 13–45 years, 84 % females) with 25-hydroxyvitamin D [25(OH)D] concentrations ≤20 ng/mL were randomly assigned to receive a supervised monthly oral vitamin D 3 of 18,000 IU (~600 IU/day, n = 17), 60,000 IU (~2000 IU/day, n = 18), 120,000 IU (~4000 IU/day, n = 18), or placebo (n = 17).

Results
There were significant dose- and time-responses of circulating 25(OH)D, 1,25-dihydroxyvitamin D [1,25(OH) 2 D], and intact parathyroid hormone (iPTH), but not fibroblast growth factor-23 (FGF-23), phosphorus and urine calcium to the vitamin D supplements. The mean 25(OH)D concentrations in the 2000 IU and 4000 IU groups reached ≥30 ng/mL as early as 8-weeks and remained at similar level at 16-weeks. The increase of 25(OH)D was significantly higher in the 4000 IU group than all the other groups at 8-weeks. The increase of 1,25(OH) 2 D was significantly higher in the 2000 IU and 4000 IU groups than the placebo at 8-weeks. Only the 4000 IU compared to the placebo significantly reduced iPTH at 8- and 16-weeks.

Conclusions
Our RCT, for the first time, comprehensively evaluated time- and dose- responses of vitamin D supplementation in overweight/obese African Americans with suboptimal vitamin D status. Circulating 25(OH)D, 1,25(OH)2D, and iPTH, but not FGF-23, phosphorus and urine calcium, respond to vitamin D supplementation in a time- and dose–response manner. By monthly dosing, 2000 IU appears to be sufficient in achieving a 25(OH)D level of 30 ng/mL in this population. However, importantly, 4000 IU, rather than 2000 IU, seems to suppress iPTH. If replicated, these data might be informative in optimizing vitamin D status and providing individualized dosing recommendation in overweight/obese African Americans.

Trial registration
ClinicalTrials.gov number: NCT01583621, Registered on April 3, 2012.

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Attached files

ID Name Comment Uploaded Size Downloads
5646 Monthly F2.jpg admin 05 Jul, 2015 21:01 28.62 Kb 647
5645 A-A RCT.pdf PDF 2015 admin 05 Jul, 2015 21:00 735.81 Kb 410
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