Meta-analysis of the effect of the maternal vitamin D level on the risk of spontaneous pregnancy loss.
Int J Gynaecol Obstet. 2017 May 13. doi: 10.1002/ijgo.12209.
Zhang H1, Huang Z2, Xiao L3, Jiang X1, Chen D1, Wei Y1.
- 2.2 X more likely in first trimester if < 20 ng of Vitamin D
- Note Vitamin D supplementation during pregnancy often does not start until second trimester – which is too late to reduce miscarriages
- Just 400 IU of daily Vitamin D reduced miscarriage (recurrent) by 3.5 times – RCT July 2016
- Miscarriage 70 percent more likely if low vitamin D (see also data on CYP27B1) – May 2016
- Miscarriage in first trimester 2.5X more likely if less than 20 ng of vitamin D – July 2015
- Second miscarriage associated with low vitamin D – review June 2018
- Miscarriage 32 percent more likely if work night shift (probably low Vitamin D) – April 2019
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- see also
- Overview Pregnancy and vitamin D
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- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
Healthy pregnancies need lots of vitamin D has the following summaryProblem
Reduces Evidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limits
RCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT
RCT = Randomized Controlled Trial
- Early Pregnancy Loss Medscape Oct 2016
"In the first trimester, embryonic causes of spontaneous abortion are the predominant etiology and account for 80-90% of miscarriages"
- Statistics on Miscarriage including failure to implant and multiples (nothing about vitamin D)
BACKGROUND: he association between vitamin D deficiency and early spontaneous pregnancy loss (SPL) is unclear.
OBJECTIVES: To assess the association of serum 25-hydroxyvitamin D (25(OH)D) and SPL.
SEARCH STRATEGY: Embase, PubMed, and Web of Science were searched for relevant papers published before February 20, 2016, using search terms including "vitamin D" and "pregnancy loss."
SELECTION CRITERIA: Case-control and cohort studies investigating the relationship of maternal serum 25(OH)D and SPL were included.
DATA COLLECTION AND ANALYSIS: Two authors independently extracted original data from the selected papers. The DerSimonian-Laird random-effects model was used to perform the meta-analysis. Heterogeneity was assessed by calculating I2 .
MAIN RESULTS: Five studies, including 10 630 pregnant women, met the inclusion criteria. There was no significant association between a low 25(OH)D level and an increased risk of SPL.
In a subgroup analysis, an extremely low 25(OH)D level (<20 ng/mL) was significantly associated with an increased risk of SPL in the first trimester (relative risk 2.24, 95% confidence interval 1.15-4.37); the heterogeneity across studies was not significant (I2 =0.0%, P=0.355).
CONCLUSIONS: Severe Vitamin D deficiency could be detrimental to early embryonic development and increase the risk of early SPLMiscarriage 2 times more likely if low vitamin D – meta-analysis May 2017
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