Circulating serum vitamin D levels in relation to metabolic syndrome in children: A systematic review and dose-response meta-analysis of epidemiologic studies
Review Obes Rev. 2021 Jul 6. doi: 10.1111/obr.13314
Parisa Rouhani 1 2, Zahra Hajhashemy 1 2, Parvane Saneei 2
Metabolic Syndrome has the followingAll items in category Metabolic Syndrome and Vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Diabetes and vitamin D
- Overview Obesity and Vitamin D
- Metabolic Syndrome risk decreases by 20 percent with each 10 ng increase in Vitamin D - April 2021
- Metabolic Syndrome and Vitamin D - review of 33 studies - March 2021
- Metabolic Syndrome far less likely if high Vitamin D – 3 meta-analyses 2021
- Metabolic Syndrome 11X more likely if have a poor Vitamin D Receptor – 2018
- Vitamin D is linked to metabolic syndrome and obesity – Aug 2019
- Risk of Metabolic syndrome for senior women reduced 42 percent by 1,000 IU of vitamin D – RCT June 2019
- Metabolic Syndrome risk reduced 3.7 X by nuts (Magnesium, Omega-3) – Dec 2018
- Metabolically Healthy – only 1 in 50 seniors in the US – Nov 2018
- Metabolic Syndrome indicators inversely proportional to vitamin D below 46 ng – Nov 2018
Items in both categories Metabolic Syndrome and Meta-analysis are listed here:
- Metabolic syndrome risk in children decreased 12 percent for each 10 ng increase in Vitamin D – meta-analysis July 2021
- Metabolic Syndrome far less likely if high Vitamin D – 3 meta-analyses 2021
- Metabolic Syndrome 13 percent more likely for every 10 ng less vitamin D – Meta-analysis Jan 2014
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
Items in both categories Metabolic Syndrome and Children are listed here:
Findings from epidemiologic studies that evaluated the relationship between serum vitamin D levels and metabolic syndrome (MetS) in children were contradictory. We conducted a systematic review and meta-analysis on the relation of serum 25(OH)D levels and MetS in children. A comprehensive search was conducted in electronic databases, up to November 2020. Eleven cross-sectional studies that reported the link between circulating vitamin D levels and MetS in children were included in the analysis. Combining 11 effect sizes from 11 cross-sectional studies with 22,196 participants revealed that highest versus lowest serum vitamin D concentration was significantly associated with a 50% reduced odds of MetS in children (OR: 0.50; 95%CI: 0.39, 0.64). Subgroup analysis by study location revealed decreased odds of MetS in both non-Asian (OR: 0.45; 95%CI: 0.33, 0.63) and Asian countries (OR: 0.54; 95%CI: 0.39, 0.76) with no heterogeneity in these subgroups. When we confined the studies to those with representative populations (n = 21,611), a significant inverse association was found between highest versus lowest circulating vitamin D level and MetS (OR: 0.55; 95%CI: 0.42, 0.71).
Dose-response analysis showed that each 10 ng/ml (or 25 nmol/L) in serum vitamin D was linearly related to a 12% reduced odds of MetS (OR: 0.88; 95%CI: 0.78, 0.99) in children. A nonlinear association was also detected between serum 25(OH)D and MetS. This meta-analysis revealed that circulating vitamin D concentration was inversely associated with odds of MetS in children, in a dose-response fashion. The same finding was found in the studies with representative populations.
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