Association of vitamin d status with mental stress-induced myocardial ischemia in patients with coronary artery disease.
Psychosom Med. 2014 Sep;76(7):569-75. doi: 10.1097/PSY.0000000000000088.
Ramadan R1, Vaccarino V, Esteves F, Sheps DS, Bremner JD, Raggi P, Quyyumi AA.
From the Department of Medicine (R.R., V.V., A.Q.),
Division of Cardiology, and Departments of Radiology (F.E.) and Psychiatry, (J.D.B.),
Emory University School of Medicine, Atlanta, Georgia; Department of Epidemiology (V.V.),
Emory University Rollins School of Public Health, Atlanta, Georgia; Department of Epidemiology (D.S.S.),
University of Florida School of Public Health, Gainesville, Florida; and Department of Cardiology (P.R.), Mazankowski Alberta Heart Institute, Alberta, Canada.
People with stable CAD were mentally stressed
They were told to prepare a 2 minute speech in 3 minutes
Their Vitamin D levels dropped from 31 ng to 24 ng
Abstract does not indicate how quickly the drop occurred. – we assume hours to days
We wonder how many stress-related diseases result in lowered vitamin D levels.
See also web
- Stress-related illnesses WebMD: Heart Disease, Asthma, Obesity, Diabetes, Headaches, Depression / Anxiety,Gastrointestinal problems, Alzheimer's disease, Accelerated aging.
- This study is described at Vitamin D Council
See also VitaminDWiki
- 96 percent vitamin D deficient – destitute asylum seekers and refugees in London – Nov 2012
- Mental stress, physical stress associations with low vitamin D - many studies
- 20 percent change in vitamin D levels of critically ill during a 24 hour period – Oct 2011 which has the following chart
Mental stress-induced (MSIMI) or physical stress-induced (PSIMI) myocardial ischemia portends a worse prognosis in patients with coronary artery disease (CAD). Vitamin D insufficiency is associated with adverse cardiovascular outcomes, but its relationship to myocardial ischemia remains unclear. We hypothesized that vitamin D insufficiency will be associated with a higher prevalence of myocardial ischemia in patients with CAD.
In 255 patients with stable CAD, myocardial perfusion imaging was performed to assess ischemia in response to mental and physical stress protocols. Vitamin D insufficiency was defined as serum 25-hydroxyvitamin D [25(OH)D] levels below 30 ng/ml, collected on the day of stress testing.
Mean (standard deviation) 25(OH)D level was 30.8 (12.8) ng/ml, and 139 (55%) patients had vitamin D insufficiency. MSIMI occurred in 30 (12%) patients and PSIMI in 67 (27%). Individuals with MSIMI had significantly lower levels of 25(OH)D as compared with those without MSIMI (24.0 [8.6] versus 31.7 [12.9], p = .002). The prevalence of MSIMI was higher in those with as compared with those without vitamin D insufficiency (17% versus 6%, p = .009). Moreover, low 25(OH)D levels remained independently associated with MSIMI after adjusting for potential confounders. Conversely, 25(OH)D levels were similar between those with or without PSIMI (29.8 [13.0] versus 31.4 [12.7], p = .37), as was the prevalence of PSIMI in those with or without vitamin D insufficiency (29% versus 24%, p = .42).
Vitamin D insufficiency is associated with a higher prevalence of MSIMI but not PSIMI among stable patients with CAD. Whether this association serves as a potential mechanism linking low vitamin D status to adverse cardiovascular outcomes warrants further investigation.