- Unlocking insights: Navigating COVID-19 challenges and Emulating future pandemic Resilience strategies with strengthening natural immunity
- VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos
- A few other items by Sunil Wimalawansa
- VitaminDWiki - Vitamin D can inhibit enveloped virus (e.g. Corona, Herpes, Bird Flu, Epstein, Hepatitis, RSV, etc.) – March 2011
- VitaminDWiki – Flu contains
- VitaminDWiki – Monkeypox - many items in 2022
- VitaminDWiki – Bird flu possible pandemic - many studies
- VitaminDWiki – Respiratory viral infection (RSV) and low vitamin D - many studies
- VitaminDWiki – Loading Dose of Vitamin D category contains:
- TOP articles in Loading Dose of Vitamin D
- VitaminDWiki – Immunity category contains
- VitaminDWiki -
52 studies in both categories of Immunity and Virus
Unlocking insights: Navigating COVID-19 challenges and Emulating future pandemic Resilience strategies with strengthening natural immunity
Heliyon 2024 Jul 17;10(15):e34691. doi: 10.1016/j.heliyon.2024.e34691
Sunil J. WimalawansaTable of Contents
Those with more vaccinations were more likely to get COVID infection
Death rates in countries with more >70% vaccinated were 100X higher than counries with <15% vaccinated
Cost of material to prevent a COVID death
The original COVID-19 vaccines, developed against SARS-CoV-2, initially mitigated hospitalizations. Bivalent vaccine boosters were used widely during 2022-23, but the outbreaks persisted. Despite this, hospitalizations, mortality, and outbreaks involving dominant mutants like Alpha and Delta increased during winters when the population’s vitamin D levels were at their lowest. Notably, 75 % of human immune cell/system functions, including post-vaccination adaptive immunity, rely on adequate circulatory vitamin D levels. Consequently, hypovitaminosis compromises innate and adaptive immune responses, heightening susceptibility to infections and complications. COVID-19 vaccines primarily target SARS-CoV-2 Spike proteins, thus offering only a limited protection through antibodies. mRNA vaccines, such as those for COVID-19, fail to generate secretory/mucosal immunity-like IgG responses, rendering them ineffective in halting viral spread. Additionally, mutations in the SARS-CoV-2 binding domain reduce immune recognition by vaccine-derived antibodies, leading to immune evasion by mutant viruses like Omicron variants. Meanwhile, the repeated administration of bivalent boosters intended to enhance efficacy resulted in the immunoparesis of recipients. As a result, relying solely on vaccines for outbreak prevention, it became less effective. Dominant variants exhibit increased affinity to angiotensin-converting enzyme receptor-2, enhancing infectivity but reducing virulence. Meanwhile, spike protein-related viral mutations do not impact the potency of widely available, repurposed early therapies, like vitamin D and ivermectin. With the re-emergence of COVID-19 and impending coronaviral pandemics, regulators and health organizations should proactively consider approval and strategic use of cost-effective adjunct therapies mentioned above to counter the loss of vaccine efficacy against emerging variants and novel coronaviruses and eliminate vaccine- and anti-viral agents-related serious adverse effects. Timely implementation of these strategies could reduce morbidity, mortality, and healthcare costs and provide a rational approach to address future epidemics and pandemics. This perspective critically reviews relevant literature, providing insights, justifications, and viewpoints into how the scientific community and health authorities can leverage this knowledge cost-effectively.
 Download the PDF from VitaminDWikiConclusions
The original COVID-19 vaccines effectively reduced hospitalizations but faced major challenges during winter outbreaks, leading to increased hospitalizations and mortality. Adequate vitamin D is critical for most human immune functions, including post-vaccination adaptive immunity. Individuals with low 25(OH)D concentrations have compromised immune systems and have less robust immune responses after vaccination, increasing their susceptibility to infections. Besides, COVID-19 mRNA vaccines predominantly target SARS-CoV-2 Spike proteins, providing limited antibody protection.
Moreover, mRNA-based COVID-19 vaccines provide no mucosal immunity, thus failing to prevent virus transmission. Additionally, mutations in the receptor binding regions of the SARS-CoV-2 viruses allow Omicron mutants to evade immune detection by antibodies. Besides, repeated bivalent vaccine boosters weaken the immune system and increase vulnerability to infection and re-infection. Consequently, exclusive reliance on COVID-19 vaccines to control outbreaks became ineffective. In contrast, Spike protein mutations do not impact the efficacy of repurposed, already approved generic, widely available early therapies like vitamin D and ivermectin, thus remain effective. Regulators should consider approving them as cost-effective adjunct therapies, and health organizations should make them available to address emerging variants and enhance vaccine efficacy in future epidemics and pandemics. Timely implementation of the actions mentioned above has the potential to reduce morbidity, mortality, and healthcare costs, providing a rational, cost-effective approach without serious adverse effects of medications for future outbreaks and pandemics.
VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos
As of March 31, 2024, the VitaminDWiki COVID page had: trial results, meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, All 26 COVID risk factors are associated with low Vit D, Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 166 COVID Clinical Trials using Vitamin D (Aug 2023) Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
5 most-recently changed Virus entries-
- The above image is automatically updated
A few other items by Sunil Wimalawansa
- Many diseases prevented if Vitamin D level higher than 50 ng -Sunil June 2024
- Many Chronic Health Diseases and Infections can controlled by 40 ng of Vitamin D – Aug 2023
- Physiological Basis for Using Vitamin D to Improve Health - May 2023
- Fight infections such as COVID with 50 ng of Vitamin D – Sunil Dec 2022
- Vitamin D: Bolus is Bogus (if more than 17 days between oral doses) – Oct 2021
- Coronavirus: How Bad Is It - Wimalawansa Feb 9 2020
VitaminDWiki - Vitamin D can inhibit enveloped virus (e.g. Corona, Herpes, Bird Flu, Epstein, Hepatitis, RSV, etc.) – March 2011
Examples of enveloped virus Coronavirus, Herpes simplex (cold sore), Shingles, Epstein-Barr, Hepatitis A & B & C, Zika, HIV, Dengue, Yellow fever, Measles, Mumps, smallpox, monkeypox, ebola, rabies, influenza A & B, West Nile, Valley Fever, Croup, Lasa Fever, Hemorrhagic Fever, H5N1 bird flu
VitaminDWiki – Flu contains
Vitamin D fights all phases of Influenza
- FACT: Vitamin D PREVENTS Influenza 7X lower risk
- FACT: Vitamin D SUPRESSES Influenza ( Vitamin D Hammer )
- Single dose of 50,000 IU of vitamin D stops Influenza symptoms
- FACT: Vitamin D PREVENTS & SUPRESSES Sepsis which is a rare but deadly consequence of Influenza
- FACT: Vitamin D enhances the activity of vaccines.
- FACT: improves Flu vaccine effectiveness and reduces side effects
- FACT: Vitamin D has virtually no side effects
- but 1 in 300 get people get muscle pain or itching due to lower magnesium levels
- FACT: Vitamin D prevents/suppresses over 120 health problems (left column)
- FACT: Both COVID-19 and Influenza are enveloped viruses
- FACT: Do not take vitamin D if Sarcoidosis, excess Calcium, Chemotherapy
- CONCLUSION To help protect/suppress influenza, take 50,000 IU of Vitamin D once a week
during the flu season if you are an average weight adult
VitaminDWiki – Monkeypox - many items in 2022
VitaminDWiki – Bird flu possible pandemic - many studies
VitaminDWiki – Respiratory viral infection (RSV) and low vitamin D - many studies
VitaminDWiki – Loading Dose of Vitamin D category contains:
206 items in category
see also Overview Loading of vitamin D Overview Toxicity of vitamin D
Better than Daily 1: Fewer chances to forget, 2) Gets past receptor barrier
Injection category has63 items
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of serious adverse reactions
Many studies report on the benefits resulting from loading dosesTOP articles in Loading Dose of Vitamin D
- Vitamin D loading dose of 30,000 IU twice a week is safe and effective – RCT July 2023
- Large dose Vitamin D before surgery was found to help by 35 studies
- Vitamin D is needed before most surgeries – many studies and RCTs
- 400,000 IU of vitamin D 3 days after COVID symptoms reduced 14 day mortality by 3X – Annweiler RCT May 2022
- High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022
- Take lots of Vitamin D at first signs of COVID
- Rapid Vitamin D Delivery May Result in Better COVID Outcomes - Dec 9, 2021
- Vitamin D loading doses quickly and safely raise levels – meta-analysis Dec 2021
- Childhood cancers – give Vitamin D loading dose if low – Oct 2021
- French recommended 200,000 IU of Vitamin D to stop COVID-19 - Jan 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
- Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021
- Vitamin D loading dose (stoss therapy) proven to improve health
- Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
- Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies – Dec 2018
- Vitamin D restoration then monthly was the most popular dosing by trials – Nov 2018
- Rickets virtually cured by 90,000 IU of Vitamin D along with daily Calcium – RCT Nov 2018
- Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
- Reasons for Low Vitamin D and what to do
- Healthy in Seven Days - Loading dose of Vitamin D – book 2014
- Can get 50,000 IU Vitamin D anywhere on the globe
FLCCC EARLY COVID Vitamin D loading doses (Sunil)
FLCCC = Front Line COVID-19 Critical Care Alliance
Table 3. A Single-Dose Regimen of Calcifediol to Rapidly Raise Serum 25(OH)D above 50 ng/mLBody Weight
(lbs)Body Weight
(kgs)Calcifediol
(mg)Equivalent
in IUIf Calcifediol is not available
a bolus of Vitamin D315-21 7-10 0.1 16,000 20,000 22-30 10-14 0.15 24,000 35,000 31-40 15-18 0.2 32,000 50,000 41-50 19-23 0.3 48,000 60,000 61-70 28-32 0.5 80,000 100,000 71-86 33-39 0.6 96,000 150,000 86-100 40-45 0.7 112,000 200,000 101-150 46-68 0.8 128,000 250,000 151-200 69-90 1.0 160,000 300,000 201-300 91-136 1.15 240,000 400,000 >300 >137 2.0 320,000 500,000
VitaminDWiki – Immunity category contains
272 items in Immunity category see also
Virus category listing has1389 items along with related searches Overview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
228 VitaminDWiki pages contained "infection" in title (June 2024)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021
Only the brain is more complex, nothing about Vitamin D
18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection
52 studies are in both Immunity and Virus categories
VitaminDWiki -
52 studies in both categories of Immunity and Virus This list is automatically updated
- Need better COVID drugs for immunocompromized (ignores Vitamin D) - Sept 2024
- Many viral diseases can be fought by immune system-augmented Vitamin D - Sunil Aug 2024
- Pfizer COVID vaccinations resulted in altering immune systems (increased IgG4 ) – Aug 2024
- Viral infections reduced 40% by monthly 100,000 IU Vitamin D – RCT review Aug 2024
- Global surge in infectious diseases as over 40 countries report outbreaks 10-fold over pre-pandemic levels - June 2024
- Vitamin D: Viral infections, Infectious diseases, EBV and MS, Virus and Cancers – Grant March 2024
- Immune System tolerance is inversely related to the number of COVID vaccinations (PubMed analysis) - Oct 2023
- Fight infections such as COVID with 50 ng of Vitamin D – Sunil Dec 2022
- The vitamins and minerals that help the immune system respond to respiratory viruses – Dec 2022
- A year after 2nd COVID vaccination, stems cells not available to fetus immune system – Nov 2022
- Vitamin D, immune System, Infection, and COVID- Video Oct 2022
- Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022
- Long-Haul more prevalent among seniors - June - 2022
- Vitamin D, Immune function, and SARS-CoV2 – May 2022
- Innate immune suppression by SARS-CoV-2 mRNA vaccinations - April 2022
- Immune system both activates and uses vitamin D (in brain, fight COVID, etc.) - March 2022
- COVID can be fought by healthy immune systems (vitamins, etc.) - Feb 2022
- Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
- Vaccine definition by the CDC seems to now include Vitamin D - Sept 2021
- Immune system - great 11-minute animated video - Aug 2021
- Vitamin D for infections and COVID (50,000 IU weekly for 3 months) – July 2021
- Vitamin D and COVID-19 both affect immune cells – June 2021
- T-cells need at least 40-50 ng of Vitamin D to fight COVID-19 - June 2021
- COVID-19 activates and Vitamin D de-activates 12 cytokines (mini-review)– May 2021
- Long-haul COVID-19 - another hint that Vitamin D should help - Dec 2020
- Strong innate immune systems do not get viral symptoms (COVID-19) – April 2021
- How healthy innate immune systems adapt to viral mutations - Feb 2021
- immune system charts (vitamin D, virus, mutation, etc)
- 600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
- Ways to boost immune system to fight COVID-19 (no protocol) - Oct 2020
- COVID-19 patients with low vitamin D had far fewer natural killer cells – Dec 2020
- Protect your immune system from COVID-19, flu, colds, etc with 10,000 IU of vitamin D etc. - Nov 2020
- 19X fewer COVID-19 infections if innate immune system activated – trial Oct 21, 2020
- Nutrients etc, which fight viruses and fortify the immune system
- Covid-19, T cells, and Vitamin D
- Mild COVID-19 quickly treated by Zinc lozenges in 4 people – June 6, 2020
- Clear Association between Influenza and low Vitamin D - March 2020
- Immune system is capable of producing 1 Quadrillion unique antibodies - Jan 2019
- Immune system is fortified by micronutrients such as vitamin D – Review Jan 2020
- Vitamin D probably can both prevent Influenza and augment vaccine effectiveness – Aug 2018
- Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
- Immunity increased by Vitamin D via cells and genes (HIV etc.) – March 2018
- Flu
- Congenital Zika Syndrome (more than microcephaly) – Spring 2016
- Dengue fever immune response and micronutrients (vitamins D, E, A, and Zinc, Iron, Chromium) – Nov 2015
- Adaptive immunity (cancer, viruses, autoimmune) and vitamin D – April 2016
- Many Infectious diseases (virus) treated and prevented by Vitamin D – review July 2009
- Immune response to respiratory viruses – vitamin D connection – review May 2015
- Vitamin D may protect against Ebola
- Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014
Many viral diseases can be fought by immune system-augmented Vitamin D - Sunil Aug 20241501 visitors, last modified 25 Aug, 2024, This page is in the following categories (# of items in each category)Attached files
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