Many gynecological diseases associated with Vitamin D less than 30 ng – Nov 2021

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Vitamin D in gynecological diseases

J Chin Med Assoc. 2021 Nov 1;84(11):1054-1059. doi: 10.1097/JCMA.0000000000000607.
Ta-Wei Chu 1 2, Jing-Yun Jhao 3, Ta-Jen Lin 3, Tzu-Wei Lin 4, Chia-Lin Wang 4, Huan-Shuo Chang 5, Li-Chun Liu 1 6, Cheng-Chang Chang 1

Background: Most reproductive system studies suggest the protective effects of vitamin D, but vitamin D deficiency and insufficiency are growing global health issues. The present study investigates the association between vitamin D deficiency/insufficiency and gynecologic diseases to identify illness risks at different serum vitamin D levels in Taiwan.

Methods: A total of 7699 female adults aged ≥20 years with results for both serum vitamin D and gynecologic-associated diseases were drawn from the Taiwan MJ cohort. We analyzed the correlation between serum vitamin D levels and results from reproductive system evaluations, including history of dysmenorrhea, results of Pap smear, high-risk human papillomavirus (HPV) infection of the cervix, mammography, and ultrasound of breast and pelvis.

Results: Over 80% of participants showed vitamin D deficiency/insufficiency. Participants with

• abnormal Pap smear results,
• high-risk HPV infection, and

(history of dysmenorrhea
showed significantly lower levels of serum vitamin D (p < 0.001-0.05).
Serum vitamin D deficiency was significantly associated with

• positive high-risk HPV infection of the cervix (p < 0.05) and
• dysmenorrhea (p < 0.001).

After controlling for age as a confounding variable for each gynecologic disease, level of serum vitamin D was significantly associated with

• abnormal breast ultrasound (odds ratio = 0.724) and
• uterus ultrasound (odds ratio = 0.673 - 0.8), and
• dysmenorrhea (odds ratio = 0.829).

Conclusion: Associations were found between vitamin D deficiency and endometriosis, uterine myoma, dysmenorrhea, abnormal Pap smear results, and high-risk HPV infection of the cervix. Therefore, vitamin D supplements may present a cost-effective benefit for the prevention and treatment of gynecologic diseases, and thus reduction of healthcare expenditures.
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