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Many drugs increase ACE2 and COVID-19 (176 page review) - Dec 2020

A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor

Pharmacology & Therapeutics. online 1 Dec. https://doi.org/10.1016/j.pharmthera.2020.107750
Murat Oz a Dietrich Ernst Lorke b c NadineKabbanid

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The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has prompted scientists to address an urgent need for defining mechanisms of disease pathology and treatment. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for COVID-19, employs angiotensin converting enzyme 2 (ACE2) as its primary target for cell surface attachment and likely entry into the host cell. Thus, understanding factors that may regulate the expression and function of ACE2 in the healthy and diseased body is critical for clinical intervention.
Over 66% of all adults in the United States are currently using a prescription drug and while earlier findings have focused on possible upregulation of ACE2 expression through the use of renin angiotensin system (RAS) inhibitors, mounting evidence suggests that various other widely administered drugs used in the treatment of

  • hypertension,
  • heart failure,
  • diabetes mellitus,
  • hyperlipidemias,
  • coagulation disorders, and
  • pulmonary disease

may also present a varied risk for COVID-19.
Specifically, we summarize mechanisms on how

  • heparin,
  • statins,
  • steroids and
  • phytochemicals,

besides their established therapeutic effects, may also interfere with SARS-CoV-2 viral entry into cells.
We also describe evidence on the effect of several vitamins, phytochemicals, and naturally occurring compounds on ACE2 expression and activity in various tissues and disease models.
This comprehensive review aims to provide a timely compendium on the potential impact of commonly prescribed drugs and pharmacologically active compounds on COVID-19 pathology and risk through regulation of ACE2 and RAS signaling.

Created by admin. Last Modification: Monday January 4, 2021 17:23:18 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
14808 ACE2 contents.jpg admin 04 Jan, 2021 17:22 61.42 Kb 362
14807 ACE2 F2.jpg admin 04 Jan, 2021 16:55 149.34 Kb 371
14806 ACE2 F1.jpg admin 04 Jan, 2021 16:54 90.34 Kb 396
14805 ACE2, the SARS-CoV-2_compressed.pdf PDF 2020 admin 04 Jan, 2021 16:50 1.01 Mb 452