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Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016

Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials

European Journal of Clinical Nutrition advance online publication, 17 August 2016; doi:10.1038/ejcn.2016.154

N Veronese1, SF Watutantrige, C Luchini3,4 , M Solmi5,6, G Sartore, G Sergi1, E Manzato, 1', M Barbagallo, S Maggi10 and B Stubbs11

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The items in both categories Diabetes and Magnesium are:


Although higher dietary intakes of magnesium (Mg) seem to correspond to lower diabetes incidence, research concerning Mg supplementation in people with or at risk of diabetes is limited. Thus, we aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes compared with placebo. A literature search in PubMed, EMBASE, SCOPUS, Cochrane Central Register of Controlled Trials and Clinicaltrials.gov without language restriction, was undertaken. Eligible studies were randomized controlled trials (RCTs) investigating the effect of oral Mg supplementation vs placebo in patients with diabetes or at high risk of diabetes. Standardized mean differences (SMD) and 95% confidence intervals (CIs) were used for summarizing outcomes with at least two studies;other outcomes were summarized descriptively. Eighteen RCTs (12 in people with diabetes and 6 in people at high risk of diabetes) were included. Compared with placebo (n = 334), Mg treatment (n = 336) reduced fasting plasma glucose (studies = 9;SMD = - 0.40;95% CI: - 0.80 to -0.00; /2 = 77%) in people with diabetes. In conditions in people at high risk of diabetes (Mg: 226;placebo = 227 participants), Mg supplementation significantly improved plasma glucose levels after a 2 h oral glucose tolerance test (three studies;SMD = - 0.35; 95% CI: - 0.62 to - 0.07;/2 = 0%) and demonstrated trend level reductions in HOMA-IR (homeostatic model assessment-insulin resistance;five studies;SMD = - 0.57;95% CI: -1.17 to 0.03;/2 = 88%). Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes and also improves insulin-sensitivity parameters in those at high risk of diabetes.

Clipped from PDF

  • "Magnesium (Mg) is . . involved in over 300 enzymatic reactions.”
  • “In humans, a large meta-analysis including over than 500 000 participants, found a significant decrease of the incidence of diabetes associated with higher Mg intake”
  • “Mg supplementation is well tolerated and without significant adverse effects. Given our findings, Mg supplementation is attracting interest in the treatment of diabetes and as prevention for diabetes in those at higher risk.”
  • “Observational studies have demonstrated that people with diabetes appear to have lower Mg levels than healthy counterparts,
  • “Previous data from observational studies have demonstrated that people without diabetes who have higher intakes of Mg are at reduced risk of diabetes.9 “
  • “Our data confirm that oral Mg supplementation can improve some outcomes in this population and overcomes limitations associated with observational data.”

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ID Name Comment Uploaded Size Downloads
7068 Mg diabetes meta-analysis.pdf PDF 2016 admin 11 Sep, 2016 20:57 170.17 Kb 528
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