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Low Vitamin D is associated with ill health for seniors – review Oct 2019


Vitamin D as a Biomarker of Ill Health among the Over-50s: A Systematic Review of Cohort Studies

Nutrients 2019, 11(10), 2384; https://doi.org/10.3390/nu11102384

VitaminDWiki
  • This study found an association of ill health with low blood levels of vitamin D.
  • There is an even stronger association with low TISSUE level of Vitamin D - due to restrictions by vitamin D Receptor and other genes

 Download the PDF from VitaminDWiki
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Silvia Caristia 1,Nicoletta Filigheddu 1,Francesco Barone-Adesi 1,Andrea Sarro 1,Tommaso Testa 1,Corrado Magnani 1,Gianluca Aimaretti 1,Fabrizio Faggiano 1,2 andPaolo Marzullo 1,3,*
1 Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, Italy
2 Epidemiology Centre of Local Health Unit of Vercelli, 12100 Vercelli, Italy
3 I.R.C.C.S. Istituto Auxologico Italiano, Piancavallo, 28921 Verbania, Italy

Background: The association between circulating levels of vitamin D and the incidence of chronic diseases is known. The identification of vitamin D as a biomarker of physiological/pathological ageing could contribute to expanding current knowledge of its involvement in healthy ageing.

Methods: According to PRISMA guidelines, a systematic review was conducted on cohorts studying the role of 25OH-Vitamin D [25(OH)D] and 1,25(OH)2-Vitamin D [1,25(OH)2D] concentrations as biomarkers of healthy ageing. We consulted MedLine, Scopus, and Web of Science to search for studies on the association between vitamin D status in populations of originally healthy adults, and outcomes of

  • longevity,
  • illness, and
  • physical and cognitive functionality.

The quality of the studies was assessed using the Newcastle Ottawa scale.

Results: Twenty cohorts from 24 articles were selected for this review. Inverse associations were found between low 25(OH)D levels and all-cause mortality, respiratory and cardiovascular events, as well as markers relating to hip and non-vertebral fractures. Associations between 1,25(OH)2D and healthy ageing outcomes gave similar results, although of lower clinical significance.

Conclusions: This systematic review pinpoints peculiar aspects of vitamin D as a multidimensional predictor of ill health in the ageing process. Further well-designed controlled trials to investigate whether vitamin D supplement results in superior outcomes are warranted in the future.

.Conclusions (from PDF)
Conclusively, 25(OH)D status acts as a worthy biomarker to predict

  • all-cause mortality,
  • pulmonary events, and
  • lung function,
  • cardiovascular/coronary events,
  • hip fractures,
  • early and/or premature death, and
  • sarcopenia incidence.

Conversely, no association was found with the risk of falls, as well as with bone mineral density, cognitive function, cardiometabolic, and cancer events in adult populations who were apparently healthy at baseline.


VitaminDWiki – Seniors contains:

427 items in Seniors

see also
Overview Seniors and Vitamin D
Overview Muscles and Vitamin D 125+ items
Overview Fractures and Falls and Vitamin D

Falls and Fractures category listing has 252 items along with related searches

Overview Alzheimer's-Cognition and Vitamin D
Overview Cancer and vitamin D
Overview Influenza and vitamin D

Cancer - Prostate category listing has 101 items along with related searches

Overview Diabetes and vitamin D
Hearing Loss appears to be prevented and treated with vitamin D

Mortality category listing has 311 items along with related searches

Overview Osteoporosis and vitamin D
Restless Legs Syndrome dramatically reduced by vitamin D, etc
Overview Rheumatoid Arthritis and vitamin D
Frailty and Vitamin D - many studies many studies
Nursing homes and Vitamin D - many studies
13 reasons why many seniors need more vitamin D (both dose and level) - July 2023 has:

  1. Senior skin produces 4X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptor genes as they age
    Receptors are needed to get Vitamin D in blood actually into the cells
  3. Many other Vitamin D genes decrease with age
  4. Since many gene activations are not detected by a blood test,
    more Vitamin D is often needed, especially by seniors
  5. Seniors are indoors more than when they were younger
    not as agile, weaker muscles; frail, no longer enjoy hot temperatures
  6. Seniors wear more clothing outdoors than when younger
    Seniors also are told to fear skin cancer & wrinkles
  7. Seniors often take various drugs which end up reducing vitamin D
    Some reductions are not detected by a vitamin D test of the blood
    statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
  8. Seniors often have one or more diseases that consume vitamin D
    osteoporosis, diabetes, Multiple Sclerosis, Cancer, ...
  9. Seniors generally put on weight as they age - and a heavier body requires more vitamin D
  10. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  11. Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
  12. Vitamin D is not as bioavailable in senior intestines
  13. Seniors with poorly functioning kidneys do not process vitamin D as well
       Seniors category has 427 items

28 Meta-analyses of Mortality


35 Meta-analyses of Breathing


39 Meta-analysis of Cardiovascular


15 Meta-analyses of Seniors


Created by admin. Last Modification: Sunday December 31, 2023 13:33:28 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
13219 50's T3.jpg admin 24 Dec, 2019 70.83 Kb 461
13218 Over 50s.pdf admin 24 Dec, 2019 630.90 Kb 415