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Less Pneumonia in those having more activated vitamin D (kidneys working)– April 2014

Vitamin D deficiency in community-acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity

Respiratory Research 2014, 15:53 doi:10.1186/1465-9921-15-53
Mathias W Pletz, Christoph Terkamp, Ulrike Schumacher, Gernot Rohde, Hartwig Schütte, Tobias Welte and Robert Bals

Objectives
We aimed to explore the association between vitamin D levels and the severity, mortality and microbiological etiology of community-acquired pneumonia.

Methods
Vitamin D levels (both, the reservoir form 25-OH and the activated form 1,25-OH2) of 300 randomly selected patients with community-acquired pneumonia due to pre-specified pathogens included in the German competence network (CAPNETZ) study were measured. Prior to statistical analysis, values of 25-OH and 1,25-OH2 were power-transformed to achieve parametric distribution. All further analyses were performed with seasonally and age adjusted values.

Results
There was only a modest (Spearman Coefficient 0.38) positive correlation between 25-OH and 1,25-OH2. For 1,25-OH2 but not 25-OH, the general linear model revealed a significant inverse correlation between serum concentration and CURB score (p = 0.011). Liver and respiratory co-morbidity were associated with significantly lower 25-OH values and renal co-morbidity with significantly lower 1,25-OH2 values. No significant differences of 1,25-OH2 or 25-OH between different pathogens (influenza virus, Legionella spp., Streptococcus pneumoniae) were detected.

Conclusion
For 1,25-OH2, we found a significant and independent (controlled for age, season and pathogen) negative correlation to pneumonia severity. Therefore, supplementation of non-activated vitamin D to protect from pneumonia may be non-sufficient in patients that have a decreased capacity to hydroxylate 25-OH to 1,25-OH2.


From the PDF- which is attached at the bottom of this page

  • “After seasonal adjustment, age had a significant impact on 1,25-OH2 levels (F1,297= 6.06, p = 0.0144) but not on 25-OH levels (F1,297= 0.03, p = 0.8588).”
    VitaminDWiki interpretation: Seniors have kidney problems, thus reducing the activation of vitamin D

Wide variance in the association between activated and typically measure serum level of vitamin D

As much as 50% variation in activated levels between individuals with the same serum level
Image

Interesting: Liver problems reduced serum level, and somewhat reduced the activated level

Kidney problems did, as expected, reduce the activated level without reducing the serum level much

Image

Interesting differences in vitamin D types vs types of Influenza

Influenza type 25-OH 1,25-OH2
Influenza A11 ng64
Influenza B13 ng31

VitaminDWiki speculation: Influenza B degrades the Kidney function.

See also VitaminDWiki

Reductions in Vitamin D is.gd/VitDReductions
Overview Kidney and vitamin D contains the following summary

  • FACT: Kidney is the primary way to activate vitamin D
  • FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
  • FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
  • FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
  • FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
  • FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
  • Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
      Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
    Calcitriol - which bypasses the need for the kidney to activate vitamin D
      Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
        Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
  • Category Kidney and Vitamin D contains 186 items

Attached files

ID Name Comment Uploaded Size Downloads
3845 D levels vs disease.jpg admin 27 Apr, 2014 19:42 162.85 Kb 1158
3844 25OH vs 1-25.jpg admin 27 Apr, 2014 19:25 64.46 Kb 880
3843 pneumonia.pdf admin 27 Apr, 2014 19:24 3.02 Mb 600
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