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Just 400 IU of daily Vitamin D reduced miscarriage (recurrent) by 3.5 times – RCT July 2016

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

Global Journal of Health Science; Vol. 9, No. 3; 2017 ISSN 1916-9736 E-ISSN 1916-9744 Published by Canadian Center of Science and Education
Mansoureh Samimi1, Fatemeh Foroozanfard1, Farzaneh Amini1 & Mojtaba Sehat2
Department of Obstetric and Gynecology, Kashan University of Medical Sciences, Kashan, IR Iran
Trauma Research Center, Kashan University of Medical Sciences, Kashan, IR Iran
Correspondence: Farzaneh Amini, Department of Obstetric and Gynecology Shabih-Khani Hospital, Shahid Beheshti Street, Kashan, Isfahan, Iran. Tel: 98-31-5554-0021. E-mail: farzanehamini1384 at gmail.com

VitaminDWiki Summary

Recurrent spontaneous abortion (least two consecutive or three non-consecutive pregnancy) before 12th week
Supplementation: from first doctor visit to 12th week of pregnancy
All women got vaginal progesterone – 400 mg per day.

DoseVitamin D
Vitamin D400 IU1313%
Placebo0 IU 1134%

See also VitaminDWiki
It is rare to find a benefit with just 400 IU of vitamin D
Note: Vitamin D levels of women in the Middle East are VERY low, so even 400 IU can help

Pregnancy category starts with

864 items in Pregnancy category

 - see also

 Download the PDF from VitaminDWiki
Note: there are several mistakes in the following abstract which are clarified in the PDF text.

Background: Recurrent spontaneous abortion is a serious problem in pregnancy, which affects between 2 and 5% of women of reproductive age. This study was designed to examine the effect of vitamin D supplementation on the occurrence of unexplained recurrent spontaneous abortion (URSA).

Methods: A double-blind randomized and controlled clinical trial was performed on 80 patients with URSA. They were treated with vaginal progesterone (400 IU/day) after confirmation of pregnancy and received vitamin D and placebo in two intervention (n=40) and control groups (n=40), respectively. The incidence of abortion and the serum levels of IL-23 were examined within 20 weeks of gestation.

Results: The levels of vitamin D3 prior to the start of the study were equal to 11.65±3.76 ng/ml and 11.53±2.39 ng/ml (p=0.86) in the intervention and control groups, respectively, which were decreased to 13.21±3.47 ng/ml and 11.08±2.76 ng/ml (p=0.004) at the end of the study, when the mean serum levels of IL-23 were equal to 18.4±3.78 pg/ml and 23.16±4.74 pg/ml in the two groups (p <0.004). The frequency of abortion in the control and intervention groups was equal to 5 (12.8%) and 13 (34.2%), respectively (p=0.03, OR=3.53, 95% CI= 1.12-11.2).

Conclusions: Vitamin D3 leads to decreased serum levels of IL-23 and incidence of abortion among women with URSA.

Attached files

ID Name Comment Uploaded Size Downloads
6882 Recurrent Miscarriage 2016.pdf PDF 2016 admin 16 Jul, 2016 13:53 203.64 Kb 799