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Ivermectin and COVID-19

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Compare Ivermectin and vitamin D

Ivermectin Vitamin D
Dosing for Preventionweeklyweekly
Availability for humans Prescription
And over-the-counter
FormOralOral, topical, etc
COVID-19 phase
Prevent, treat, long-haul
All phases Prevent - Great
Early treat - Good
Late treat - poor
Long-haul possibly
Allowed for COVID-19In some placesin some places
Safe: # of doses
given in 50 years
> 3 billion> 3 billion
Able to deal with virus
that has mutated
Fight more than just COVID-19unsureProven 90+ health problems

Both are heavily supported by both observations and clinical trials
Not clear which is best
Note: Ivermectin raises vitamin D levels/ (see 6 studies further down this page)

Ivermectin Videos on VitaminDWIKI

Ivermectin raises levels of vitamin D (by decreasing CYP3A4) - 6 studies

  1. Interplay between Vitamin D and the Drug Metabolizing Enzyme CYP3A4 - 2014   PDF
  2. Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes
    • Xenobiotica, . 1998 Mar;28(3):313-21. doi: 10.1080/004982598239597
  3. Metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, possible adverse and toxic effects   March 2021   PDF
  4. Drug-metabolizing enzymes CYP3A as a link between tacrolimus and vitamin D in renal transplant recipients: is it relevant in clinical practice? - July 2019 https://doi.org/10.1007/s00467-018-4030-3
    • Image
  5. CYP3A4 Induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients With CYP24A1 Mutations -2017 FREE PDF
    • Image
  6. Vitamin D levels massively changed by CYP3A4 gene (drugs such as Ivermectin and anti-epileptics)

Note: Ivermectin treats river blindness, which is independently treated by Vitamin D

Ivermectin probably not prevent COVID-19 for very long - half-life is <36 hours

  • Ivermectin, ‘Wonder drug’ from Japan: the human use perspective - Feb 2011   PDF
  • ""The half-life of ivermectin in humans is 12–36 hours, while metabolites may persist for up to three days."

Weekly Ivermectin prevents COVID-19 - Feb 2021

Is ivermectin ready to be part of a public health policy for COVID-19 prophylaxis?
 Download the PDF from VitaminDWiki

Similar to weekly vitamin D dosing, which provides far more benefits

Goa (1.8 million, India) to give Ivermectin every 5 days to all residents - May 11, 2021

"...12 mg of Ivermectin for a period of five days as prophylaxis to protect against Covid-19"
"...Goa—one of India’s smallest states by population—has witnessed a recent surge in Covid-19 cases and on Tuesday it reported 3,124 new cases and 75 fatalities on Tuesday evening."

1 cent of Ivermectin decreased risk of COVID-19 by half (India healthcare workers) - Feb 2021

Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study
 Download the PDF from VitaminDWiki
Video by Dr. john Cambell on the study - May 6, 2021

Ivermectin RCT in Israel: 2.6X more likely for outpatient infection to go away - preprint May 2021

Favorable outcome on viral load and culture viability using Ivermectin in early treatment of non-hospitalized patients with mild COVID-19 – A double-blind, randomized placebo-controlled trial
doi: https://doi.org/10.1101/2021.05.31.21258081

Background Ivermectin, an anti-parasitic agent, also has anti-viral properties. Our aim was to assess whether ivermectin can shorten the viral shedding in patients at an early-stage of COVID-19 infection.

Methods The double-blinded trial compared patients receiving ivermectin 0·2 mg/kg for 3 days vs. placebo in non-hospitalized COVID-19 patients. RT-PCR from a nasopharyngeal swab was obtained at recruitment and then every two days. Primary endpoint was reduction of viral-load on the 6th day (third day after termination of treatment) as reflected by Ct level>30 (non-infectious level). The primary outcome was supported by determination of viral culture viability.

Results Eighty-nine patients were eligible (47 in ivermectin and 42 in placebo arm). Their median age was 35 years. Females accounted for 21·6%, and 16·8% were asymptomatic at recruitment. Median time from symptom onset was 4 days. There were no statistical differences in these parameters between the two groups.

On day 6, 34 out of 47 (72%) patients in the ivermectin arm reached the endpoint, compared to 21/ 42 (50%) in the placebo arm (OR 2·62; 95% CI: 1·09-6·31). In a multivariable logistic-regression model, the odds of a negative test at day 6 was 2.62 time higher in the ivermectin group (95% CI: 1·06–6·45). Cultures at days 2 to 6 were positive in 3/23 (13·0%) of ivermectin samples vs. 14/29 (48·2%) in the placebo group (p=0·008).

Conclusions There were significantly lower viral loads and viable cultures in the ivermectin group, which could lead to shortening isolation time in these patients.
 Download the PDF from VitaminDWiki

Ivermectin reduced COVID-19 deaths in Peru by 14X - March 19, 2021

Ivermectin reduced COVID-19 deaths in Peru by 14X, after new president halted it, the death rate increased 13X – March 18, 2021

Top Yale Doctor/Researcher: ‘Ivermectin works,’ including for long-haul COVID - March 22, 2021

Top Yale Doctor/Researcher: ‘Ivermectin works,’ including for long-haul COVID TrialSiteNews
Prevention, treatment, and long-haul
"“When you have people that can’t breathe for five, six, eight, nine months and they tried multiple drugs and supplements with no success, and you give them ivermectin,” Dr. Santin said of long-haul patients, “and you see that they start immediately feeling better, this is not placebo. This is real.”

Ivermectin - Long-Haul

NOT Using Ivermectin Is Unethical And Immoral - Jan 2021

Not Using Ivermectin, One Year In, Is Unethical And Immoral TrialSiteNews
The family pushed to have Ivermectin given to the 80-year old woman in ICU
She got so much benefit that she left the ICU 48 hours later
The non- ICU portion of the hospital refused to continue the Ivermectin
The family had to sue the hospital, and the judge forced the hospital to continue the Ivermectin
She was released to a rehabilitation facility soon after

7X less morbidity in those African countries using Ivermectin - March 26, 2021

Why COVID-19 is not so spread in Africa: How does Ivermectin affect it?
Preprint - doi: https://doi.org/10.1101/2021.03.26.21254377
 Download the PDF from VitaminDWiki

Background: Scientists have so far been unable to determine the reason for the low number of COVID-19 cases in Africa.

Objective: To evaluate the impact of ivermectin interventions for onchocerciasis on the morbidity, mortality, recovery, and fatality rates caused by COVID-19.

Method: A retrospective statistical analysis study of the impact of ivermectin against COVID-19 between the 31 onchocerciasis-endemic countries using the community-directed treatment with ivermectin (CDTI) and the non-endemic 22 countries in Africa. The morbidity, mortality, recovery rate, and fatality rate caused by COVID-19 were calculated from the WHO situation report in Africa. We investigated the onchocerciasis endemic 31 countries and the non-endemic 22 countries. Statistical comparisons used by the Welch test of them in the two groups were made.

Results: The morbidity and mortality were statistically significantly less in the 31 countries using CDTI. The recovery and fatality rates were not statistically significant difference. The average life expectancy was statistically significantly higher in the non-endemic countries.

Conclusions: The morbidity and mortality in the onchocerciasis endemic countries are lesser than those in the non-endemic ones. The community-directed onchocerciasis treatment with ivermectin is the most reasonable explanation for the decrease in morbidity and fatality rate in Africa. In areas where ivermectin is distributed to and used by the entire population, it leads to a significant reduction in mortality.

Countries using prophylactic chemotherapy with Ivermectin have far fewer COVID-19 infections - Jan 2021

A COVID-19 prophylaxis? Lower incidence associated with prophylactic administration of ivermectin
Int J Antimicrob Agents. 2021 Jan;57(1):106248. doi: 10.1016/j.ijantimicag.2020.106248.
Martin D Hellwig 1, Anabela Maia 2
 Download the PDF from VitaminDWiki

COVID-19 incidence worldwide
Another chart shows similar reduction for African countries

As COVID-19 (coronavirus disease 2019) continues to rapidly spread throughout the world, the incidence varies greatly among different countries. These differences raise the question whether nations with a lower incidence share any medical commonalities that could be used not only to explain that lower incidence but also to provide guidance for potential treatments elsewhere. Such a treatment would be particularly valuable if it could be used as a prophylactic against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) transmission, thereby effectively slowing the spread of the disease while we await the wide availability of safe and effective vaccines.
Here, we show that countries with routine mass drug administration of prophylactic chemotherapy including ivermectin have a significantly lower incidence of COVID-19. Prophylactic use of ivermectin against parasitic infections is most common in Africa and we hence show that the reported correlation is highly significant both when compared among African nations as well as in a worldwide context. We surmise that this may be connected to ivermectin's ability to inhibit SARS-CoV-2 replication, which likely leads to lower infection rates. However, other pathways must exist to explain the persistence of such an inhibitory effect after serum levels of ivermectin have declined. It is suggested that ivermectin be evaluated for potential off-label prophylactic use in certain cases to help bridge the time until a safe and effective vaccine becomes available.

Mercola Jan 25, 2021


  • "The data shows the ability of the drug Ivermectin to prevent COVID-19, to keep those with early symptoms from progressing to the hyper-inflammatory phase of the disease, and even to help critically ill patients recover. - FLCCC Alliance" FLCCC = Frontline COVID-19 Critical Care Alliance
  • "Like hydroxychloroquine, ivermectin is an antiparasitic drug with a well-documented safety profile and “proven, highly potent, antiviral and anti-inflammatory properties.”12 It’s been on the market since 1981 and is on the World Health Organization’s list of essential medicines. It’s also inexpensive, with a treatment course costing less than $2 in countries such as India and Bangladesh"
  •  FLCCC Press release Jan 7
  •  FLCCC Clinital summary

NIH is no longer opposed to the use of Ivermectin - Jan 20, 2021

"The National Institutes of Health (NIH) has dropped its recommendation against the inexpensive antiparasitic drug ivermectin for treatment of COVID-19, and the agency now advises it can't recommend for or against its use, leaving the decision to physicians and their patients."

Doctors Ask Arizona Gov to Facilitate COVID-19 Treatment with Ivermectin - Jan 26, 2021

Arizona chapter of American Physicians and Surgeons

Ivermectin protocol and experiences

Several Facebook pages - including Ivermectin and Long Haul

Use of Ivermectin did not change COVID-19 outcomes - meta-analysis Jan 29, 2021

Outcomes of Ivermectin in the treatment of COVID-19: a systematic review and metaanalysis

 Download the PDF from VitaminDWiki

Covid-19: Ivermectin’s politicization is a warning sign for doctors turning to orphan treatments

British Medical Journal April 1. 2021
Doctors are not permitted to use a drug that has been successfully used over a billion times for other health problems
Interesting that US doctors are permitted to use other drugs for off-label health problems,
   but not for this particular health problem, for which tens of billions of dollars have been invested (vaccines)
     lots to be gained by promoting vaccines, but virtually no one will gain by promoting potential pre-existing solutions

The Drug that Cracked Covid - Ivermectin May 2021

 Download the PDF from VitaminDWiki

Review of Evidence: Ivermectin helps - May 2021

Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19
 Download the PDF from VitaminDWiki

Ivermectin helped in Mexico City - May 2021

Gave Ivermectin (several pills) to those with symptoms (but not in hospital)
"The Mexico City study team generated compelling results in that they reduced the pressures on hospital system by 52% to 76% depending on a number of factors."
COVID-19 hospitalizations

Bird = British Ivermectin Recomendation Development

Started after watching FLCC presentation to US senate in Dec 2020
BIRD hosted the first International Ivermectin for Covid Conference in May 2021 closing video

Additional groups trying to get Invermetin allowed/used

FLCCC Alliance,
World Doctors Alliance,
Médicos pela Vida Brazil),
Long Covid-19 Foundation (UK),
Covid Medical Network Australia,
https://www.e-bmc.co.uk/ strongly associated with BIRD

Ivermectin DID NOT decrease COVID-19 severity - RCT March 2021

Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19 - A Randomized Clinical Trial
ivermectin, 300 μg/kg of body weight per day for 5 days
with mild disease and symptoms for 7 days or fewer (at home or hospitalized)
 Download the PDF from VitaminDWiki

Created by admin. Last Modification: Tuesday September 14, 2021 23:09:39 GMT-0000 by admin. (Version 130)
Ivermectin and COVID-19        
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16145 Ivermectin Aug 27.jpg admin 27 Aug, 2021 01:41 225.76 Kb 145
16058 Ivermectin RCT March 2021.pdf PDF 2021 admin 10 Aug, 2021 00:44 361.80 Kb 33
15714 Ivermectin Mexico city.jpg admin 05 Jun, 2021 20:04 17.76 Kb 443
15713 Ivermectin review.jpg admin 05 Jun, 2021 19:51 22.20 Kb 427
15712 Ivermectin review.pdf PDF 2021 admin 05 Jun, 2021 19:35 975.54 Kb 54
15711 Israel Ivermectin RCT.pdf PDF 2021 admin 05 Jun, 2021 01:09 593.41 Kb 58
15688 CYP3A4.jpg admin 31 May, 2021 23:01 40.37 Kb 480
15686 Weekly ivermectin prevent COVID.pdf PDF 2021 admin 31 May, 2021 20:03 246.73 Kb 65
15680 The-Drug-that-Cracked-Covid-by-Michael-Capuzzo.pdf PDF 2021 admin 31 May, 2021 15:10 3.65 Mb 70
15590 Ivermectin Japan.pdf admin 16 May, 2021 13:54 583.77 Kb 77
15589 CPY3A4 induce, inhibit.jpg admin 16 May, 2021 13:22 47.92 Kb 569
15587 Metabolism and interactions.pdf PDF 2021 admin 16 May, 2021 13:10 920.44 Kb 76
15586 Interplay.pdf admin 16 May, 2021 13:02 548.10 Kb 67
15558 Ivermectin HCW India.pdf PDF 2021 admin 07 May, 2021 15:53 422.94 Kb 57
15417 IVM April 12.jpg admin 12 Apr, 2021 15:49 171.61 Kb 613
15350 Ivermectin Long Haul Feb 2021.pdf PDF 2021 admin 30 Mar, 2021 22:33 1.50 Mb 95
15336 Ivermetin and PCT.jpg admin 29 Mar, 2021 00:15 22.33 Kb 731
15335 C19-Ivermectin prophylactic Hellwig.pdf PDF 2021 admin 29 Mar, 2021 00:15 782.71 Kb 83
15334 Africa and Invermectin.jpg admin 28 Mar, 2021 21:52 72.93 Kb 760
15333 Ivermectin Africa.pdf PDF 2021 admin 28 Mar, 2021 21:51 58.14 Kb 100
14946 Invermectin logRR.jpg admin 30 Jan, 2021 23:05 54.32 Kb 916
14945 Invermectin meta.jpg admin 30 Jan, 2021 23:05 194.85 Kb 916
14944 Ivermectin meta-analysis.pdf PDF 2021 admin 30 Jan, 2021 22:29 566.09 Kb 117
14923 FLCCC-PressRelease-NIH-C19-Panel-FollowUp-Jan7-2021.pdf admin 26 Jan, 2021 01:15 248.84 Kb 137
14922 One-Page-Summary-of-the-Clinical-Trials-Evidence-for-Ivermectin-in-COVID-19.pdf admin 26 Jan, 2021 01:13 289.78 Kb 150
14921 Inver summary Jan 25.jpg admin 26 Jan, 2021 01:01 174.37 Kb 447
14920 ifpe Jan 25.png admin 26 Jan, 2021 00:59 351.26 Kb 511
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