It is well known that TOO LITTLE vitamin D is associated with health problems
TOO MUCH vitamin D may also be associated with health problems
Possible reasons include:
- Body is out of balance with too much vitamin D – consider adjusting cofactors
CURE: Increase Vitamin K2
- prevents excess Calcium created by lots of vitamin D from going to wrong places in body (arteries, prostate, etc)
CURE: Increase Magnesium – which is vital for health but is consumed by Vitamin D
CURE: Reduce Calcium – which may be in excess due to high level of vitamin D
- Large doses of vitamin D taken very infrequently (quarterly, yearly) is known to cause imbalance and problems
CURE: Take vitamin more often than than once every 20 days
- The body might change the Vitamin D Binding Protein so as to increase vitamin D levels when sick
- Sick people had attempted to heal themselves by adding Vitamin D or visiting a sunny climate
- Result of excess Vitamin A reducing the benefits of Vitamin D in the blood
CURE: Don't get your Vitamin D from cod liver oil - which appears to have too much Vitamin A
It appears that only Nordic studies of mortality have found problems with high levels of vitamin D
- Drug dosage often assumes low Vitamin D, High vitamin D increases/decreases dose potency
Example: Vitamin D can greatly amplify various Chemo drugs, making them deadly
CURE: Have doctors adjust prescribed dosage when a patient is taking lots of vitamin D
- Some Drugs Deplete Magnesium
People may increase their vitamin D levels too high so as to feel benefits even with Magnesium limitation
- Had been taking Vitamin D2 - which is known to cause problems
CURE:mTake Vitamin D3 instead of D2
- J-Shaped does not acutally exist - it was due to old style of Vitamin D tests having too high of readings
See PubMed item below on this page
- Statins used in last decade of life decreased the vitamin D levels
+CURE: Do noit take statins or take more vitamin D
- Search VitaminDWiki for “U SHAPED” 280 items as of March 2015
- Search VitaminDWiki for “J SHAPED” 1070 items as of April 2017
- Does too much Vitamin D cause problems – possible for allergies, maybe for falls – Review June 2016
- Even if a J curve exists, it is 50X better to give vitamin D than not give it – May 2013
Article Title: When Is a U-Curve Actually a J-Curve? Is It Really Too Much of a Good Thing?
- 1 in 6 critically ill in India have high levels of vitamin D (100 ng) – March 2015
Suspect due to taking lots of Vitamin D2 - the commonly prescribed form in various countries
- Increased chance of death if enter hospital with vitamin D greater than 60 ng (u-shaped) – April 2014
- Mortality increased with highest levels of vitamin D – article and 4 letters Aug 2012
- Vitamin D and Pancreatic Cancer Risk - No U-Shaped Curve - Mar 2012 statistical artifact
- Is High Dose Vitamin D Harmful? PDF file, not page Feb 2012
- 2X more complications after heart surgery associated with high level of vitamin D – Jan 2013
- Is 50 ng of vitamin D too high, just right, or not enough has a section on U-Shaped responses
- 45 ng vitamin D may be enough (what about vitamin A)- Aug 2013
- All items in category Vitamin A and Vitamin D
- Is Vitamin D Supplementation Responsible for the Allergy Pandemic – May 2012
Hypothesis: Low vitamin D as a fetus then lots of vitamin D as an infant confuses the body
- Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014
Vitamin D levels of 150 ng cured MS, etc. - but needed to limit the amount of Calcium, increase Vitamin B2, etc.
- Low testosterone is associated with levels higher than 40 ng of vitamin D (U-shaped)– July 2014
- Fertility in both women and men improves with more vitamin D (but less than 50 ng for men) – Dec 2013
- Hypothesis: Vitamin K will reduce prostate blood vessel problems – Jan 2015
Lots of vitamin D (without Vitamin K) ==> more Calcium in tiny blood vessels, such as in Prostate
- Overview Kidney Stones and vitamin D Used to believe that high vitamin D==> stones. No longer certain.
- Many more people now have vitamin D levels above 50 ng, especially seniors – May 2015
- Overview Toxicity of vitamin D (short term excess Vitamin D)
- Search PubMed for ("j-shaped" OR "u-shaped") "vitamin d" 63 items as of Jan 2016, some of which follow
- Letter to the Editor: The J-shaped 25-hydroxyvitamin D concentration-cardiovascular disease mortality relation is very likely due to starting vitamin D supplementation late in life. Grant June 2015
- Cord blood vitamin D and neurocognitive development are nonlinearly related in toddlers June 2015
- A Reverse J-Shaped Association Between Serum 25-Hydroxyvitamin D and Cardiovascular Disease Mortality: The CopD Study June 2015
- 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and postoperative outcome in cardiac surgery. Jan 2015
- The role of vitamin D for cardiovascular disease and overall mortality Fall 2014
- Is there a reverse J-shaped association between 25-hydroxyvitamin D and all-cause mortality?
Results from the U.S. nationally representative NHANES July 2013
- U-Shaped Association Between Serum 25-Hydroxyvitamin D and Fracture Risk in Older Men:
Results from the Prospective Population Based CHAMP Study March 2014, more fractures if > 30 ng
- Cross-sectional study of vitamin D levels, immunologic and virologic outcomes in HIV-infected adults. April 2013
U-shaped relationship between 1,25(OH)2D and viral load, Full free text on-line
- Vitamin D insufficiency and chronic diseases: hype and reality Aug 2012
- Positive association between circulating 25-hydroxyvitamin D levels and prostate cancer risk:
new findings from an updated meta-analysis May 2014, 17% higher
- Association of vitamin D with respiratory outcomes in Canadian children July 2014
For ever having had asthma: 20-30 ng odds ratio = 1, 30 ng odds ratio = 2.1
No increase of mortality with high vitamin D levels (j-shaped) when tests are standardized – April 2017
The Reverse J-Shaped Association Between Serum Total 25-Hydroxyvitamin D Concentration and All-Cause Mortality: The Impact of Assay Standardization.
Am J Epidemiol. 2017 Apr 15;185(8):720-726. doi: 10.1093/aje/kww244.
Durazo-Arvizu RA, Dawson-Hughes B, Kramer H, Cao G, Merkel J, Coates PM, Sempos CT.
We evaluated the impact of standardizing the originally measured serum total 25-hydroxyvitamin D (25(OH)D) values from Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994) on the association between 25(OH)D and rate of all-cause mortality. Values were standardized to the gold-standard laboratory method. Follow-up from 1990-2006 consisted of 15,099 participants aged at least 20 years at baseline, among whom there were 3,784 deaths. Relative risk of death was adjusted for age, sex, race/ethnicity, and season using Poisson regression.
Results were obtained for eight 25(OH)D (nmol/L) categories: <20 nmol/L, 20-29 nmol/L, 30-39 nmol/L, 40-49 nmol/L, 50-59 nmol/L, 60-74 nmol/L, 75-99 nmol/L (reference), and ≥100 nmol/L. Assay standardization dramatically shifted original 25(OH)D values toward zero. Accordingly, risk ≥120 nmol/L could not be evaluated (i.e., n = 7 and ndeaths = 2). Relative risk (95% confidence interval (CI)) <40 nmol/L remained significant (30-39 nmol/L: relative risk (RR) = 1.4 (95% CI: 1.1, 1.6); 20-29 nmol/L: RR = 1.6 (95% CI: 1.3, 1.9), and <20 nmol/L: RR = 2.1 (95% CI: 1.6, 2.7).
However, adjusted relative risk estimates for 25(OH)D levels ≥40 nmol/L were no longer significant (40-49 nmol/L: RR = 1.2 (95% CI: 0.99, 1.4); 50-59 nmol/L: RR = 1.2 (95% CI: 1.04, 1.4); 60-74 nmol/L: RR = 1.1 (95% CI: 0.94, 1.2); 75-99 nmol/L: RR = 1.0 (referent), and ≥100 nmol/L: RR = 1.1 (95% CI: 0.6, 2.1).
In summary, after standardization, risk of death from all causes increased with decreasing 25(OH)D <40 nmol/L, while there was no association with values in categories between 40 nmol/L and 120 nmol/L.
PMID: 28338905 DOI: 10.1093/aje/kww244 Publisher wants $42 for the PDF
- Is Vitamin D Supplementation Responsible for the Allergy Pandemic – May 2012