Toggle Health Problems and D

Is Vitamin D an antioxidant – more studies needed – Oct 2018

The controversial role of vitamin D as an antioxidant: results from randomised controlled trials

Nutrition Research Reviews https://doi.org/10.1017/S0954422418000197
Sara Tagliaferri (a1), Debora Porri (a2), Rachele De Giuseppe (a2), Matteo Manuelli (a2) matteo.manuelli at unimi.it



Vitamin D and Omega-3 both reduce Inflammation

Inflammation Intervention trials using Vitamin D:

Pages listed in BOTH the categories Omega-3 and Inflammation

Some studies published after the current study was submitted

  • The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials June 2018 doi: 10.1055/a-0630-1303 Free PDF "Overall, this meta-analysis shows that in diabetic patients, taking vitamin D had significant effects on hs-CRP and MDA levels, and significantly increased NO, TAC and GSH levels."
  • Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter Aug 2018 Free PDF https://doi.org/10.1371/journal.pone.0200040

Vitamin D: Oxidative Stress, Immunity, and Aging - 2016 Book 

Table of Contents
Vitamin D: An Overview
Vitamin D: A Fountain of Youth in Gene Regulation; Peter W. Jurutka, G. Kerr Whitfield, Ryan Forster...
Vitamin D Receptor: Genomic and Epigenomic Effects; Prashant K. Singh and Moray J. Campbell
Vitamin D Analogs and Their Clinical Uses; Glenville Jones
Extrarenal CYP27B1 and Vitamin D Physiology; Martin Hewison
Oxidative Stress
Vitamin D and Oxidative Stress; Huei-Ju Ting and Yi-Fen Lee
Vitamin D3 Upregulated Protein 1 (VDUP1): Roles in Redox Signaling and Stress-Mediated Diseases; ...
Vitamin D and Its Role in Photoprotection of the Skin; Clare Gordon-Thomson, Wannit Tongkao-on, and Rebecca S. Mason
Vitamin D and Adipose Tissue: 1α, 25-Dihydroxyvitamin D3 (Calcitriol) Modulation of Energy Metabolism, Reactive Oxygen Species, and Inflammatory Stress; Antje Bruckbauer and Michael B. Zemel
Membrane Receptors for Vitamin D Metabolites and the Role of Reactive Oxygen Species; Ramesh C. Khanal and Ilka Nemere
Immunity and Disease
Vitamin D and Human Innate Immunity; Eun-Kyeong Jo, Dong-Min Shin, and Robert L. Modlin
Vitamin D and Autoimmune Disease; Colleen E. Hayes, Corwin D. Nelson, and Justin A. Spanier
Vitamin D: Anti-Inflammatory Actions to Prevent and Treat Diseases; Jun Sun
Vitamin D and Infection; Jim Bartley and Carlos A. Camargo, Jr.
Potential Role of Vitamin D and Fibroblast Growth Factor 23–Klotho System in Aging; Nasimul Ahsan, Syed K. Rafi, ...
Vitamin D and Cardiovascular Disease; Jared P. Reis and Pamela L. Lutsey
Vitamin D, Aging, and Chronic Diseases; Pentti Tuohimaa
Vitamin D: Defending the Aging Nervous System; Cédric Annweiler

Increased oxidative stress has been implicated as a potential causal factor in the development of several diseases. In the last decade, an extensive literature has been produced on vitamin D, not limited to its well-known function like a steroid hormone on skeletal tissue, but for its potential pleiotropic role in human health. Several researchers have suggested relationships between vitamin D intake and health outcomes such as cancer prevention and increased immunity, or possible role in preventing diabetes, and in inflammation. Little is known about its antioxidant effect. The aim of the present review was to explore major evidence regarding the potential scavenger capacity of vitamin D in high-evidence human studies. Studies considered by the present review suggest that the potential role of vitamin D as an antioxidant could not be confirmed. Current literature showed controversial effects about the ability of cholecalciferol to prevent or ameliorate oxidative stress biomarkers, and there is need of further and high-quality studies testing the antioxidant effect of vitamin D supplementation.


  • 1. Finkel, T & Holbrook, NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408, 239–247. CrossRef | Google Scholar | PubMed
  • 2. Valko, M, Leibfritz, D, Moncola, J, et al. (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39, 44–84. CrossRef | Google Scholar | PubMed
  • 3. Schafer, FQ & Buettner, GR (2001). Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 30, 1191–1212. CrossRef | Google Scholar | PubMed
  • 4. Dalle-Donne, I, Rossi, R, Colombo, R, et al. (2006) Biomarkers of oxidative damage in human disease. Clin Chem 52, 601–623. CrossRef | Google Scholar | PubMed
  • 5. Dhalla, NS, Temsah, RM & Netticadan, T (2000) Role of oxidative stress in cardiovascular diseases. J Hypertens 18, 655–673. CrossRef | Google Scholar | PubMed
  • 6. Jenner, P (2003) oxidative stress in Parkinson’s disease. Ann Neurol 53, Suppl. 3, S26–S38. CrossRef | Google Scholar | PubMed
  • 7. Sayre, LM, Smith, MA & Perry, G (2001) Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem 8, 721–738. CrossRef | Google Scholar | PubMed
  • 8. Parikh, B & Patel, VH (2018) Total phenolic content and total antioxidant capacity of common Indian pulses and split pulses. J Food Sci Technol 55, 1499–1507. Google Scholar | PubMed
  • 9. Institute Of Medicine (2011) DRI: Dietary Reference Intake: Calcium and Vitamin D. Washington, DC: The National Academies Press. Google Scholar
  • 10. Plum, LA & DeLuca, HF (2010) Vitamin D, disease and therapeutic opportunities. Nat Rev Drug Discov 9, 941–955. CrossRef | Google Scholar | PubMed
  • 11. Hoeck, AD & Pall, ML (2011) Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue? Med Hypotheses 76, 208–213. CrossRef | Google Scholar | PubMed
  • 12. Holick, MF (2004) Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 79, 362–371. CrossRef | Google Scholar | PubMed
  • 13. Ticinesi, A, Meschi, T, Lauretani, F, et al. (2016) Nutrition and inflammation in older individuals: focus on vitamin D, n-3 polyunsaturated fatty acids and whey proteins. Nutrients 29, 186. CrossRef | Google Scholar
  • 14. Wang, EW, Siu, PM, Pang, MY, et al. (2017) Vitamin D deficiency, oxidative stress and antioxidant status: only weak association seen in the absence of advanced age, obesity or pre-existing disease. Br J Nutr 118, 11–16. CrossRef | Google Scholar | PubMed
  • 15. Palacios, C & Gonzalez, L (2014) Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol 144, 138–145. CrossRef | Google Scholar | PubMed
  • 16. Ghiselli, A, Serafini, M, Natella, F, et al. (2000) Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radic Biol Med 29, 1106–1114. CrossRef | Google Scholar | PubMed
  • 17. Namdev, S, Bhat, V, Adhisivam, B, et al. (2014) oxidative stress and antioxidant status among neonates born to mothers with pre-eclampsia and their early outcome. J Matern Fetal Neonatal Med 27, 1481–1484. CrossRef | Google Scholar | PubMed
  • 18. Asemi, Z, Samimi, M, Tabassi, Z, et al. (2013) Vitamin supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women. J Nutr 143, 1432–1438. CrossRef | Google Scholar | PubMed
  • 19. de Medeiros Cavalcante, IG, Silva, AS, Costa, MJ, et al. (2015) Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency: vitamin D3 megadose reduces inflammatory markers. Exp Gerontol 66, 10–16. CrossRef | Google Scholar | PubMed
  • 20. Scholten, SD, Sergeev, IN, Song, Q, et al. (2015) Effects of vitamin D and quercetin, alone and in combination, on cardiorespiratory fitness and muscle function in physically active male adults. Open Access J Sports Med 6, 229–239. CrossRef | Google Scholar | PubMed
  • 21. Holick, MF, Binkley, NC, Bischoff-Ferrari, HA, et al. (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96, 1911–1930. CrossRef | Google Scholar | PubMed
  • 22. Levy, MA, McKinnon, T, Barker, T, et al. (2015) Predictors of vitamin D status in subjects that consume a vitamin D supplement. Eur J Clin Nutr 69, 84–89. CrossRef | Google Scholar | PubMed
  • 23. Nikooyeh, B, Neyestani, TR, Tayebinejad, N, et al. (2014) Daily intake of vitamin D- or calcium-vitamin D-fortified Persian yogurt drink (doogh) attenuates diabetes-induced oxidative stress: evidence for antioxidative properties of vitamin D. J Hum Nutr Diet 27, Suppl. 2, 276–283. CrossRef | Google Scholar | PubMed
  • 24. Shab-Bidar, S, Neyestani, TR & Djazayery, A (2015) The interactive effect of improvement of vitamin D status and VDR FokI variants on oxidative stress in type 2 diabetic subjects: a randomized controlled trial. Eur J Clin Nutr 69, 216–222. CrossRef | Google Scholar | PubMed
  • 25. Asemi, Z, Hashemi, T, Karamali, M, et al. (2013) Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial. Am J Clin Nutr 98, 1425–1432. CrossRef | Google Scholar | PubMed
  • 26. Eftekhari, MH, Akbarzadeh, M, Dabbaghmanesh, MH, et al. (2014) The effect of calcitriol on lipid profile and oxidative stress in hyperlipidemic patients with type 2 diabetes mellitus. ARYA Atheroscler 10, 82–88. Google Scholar | PubMed
  • 27. Yiu, YF, Yiu, KH, Siu, CW, et al. (2013) Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes. Atherosclerosis 227, 140–146. CrossRef | Google Scholar | PubMed
  • 28. Tamadon, MR, Soleimani, A, Keneshlou, F, et al. (2018) Clinical trial on the effects of vitamin D supplementation on metabolic profiles in diabetic hemodialysis. Horm Metab Res 50, 50–55. Google Scholar | PubMed
  • 29. Martins, D, Meng, YX, Tareen, N, et al. (2014) The effect of short term vitamin D supplementation on the inflammatory and oxidative mediators of arterial stiffness. Health (Irvine Calif) 6, 1503–1511. Google Scholar | PubMed
  • 30. Witham, MD, Dove, FJ, Sugden, JA, et al. (2012) The effect of vitamin D replacement on markers of vascular health in stroke patients – a randomised controlled trial. Nutr Metab Cardiovasc Dis 22, 864–870. CrossRef | Google Scholar | PubMed
  • 31. Bischoff-Ferrari, HA, Giovannucci, E, Willett, WC, et al. (2006) Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 84, 18–28. CrossRef | Google Scholar | PubMed
  • 32. Wu, CC, Chang, JH, Chen, CC, et al. (2011) Calcitriol treatment attenuates inflammation and oxidative stress in hemodyalisis patients with secondary hyperparathyroidism. Tohoku J Exp Med 223, 153–159. CrossRef | Google Scholar
  • 33. Sharifi, N, Amani, R, Hajiani, E, et al. (2014) Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? Endocrine 47, 70–80. CrossRef | Google Scholar | PubMed
  • 34. Sepehrmanesh, Z, Kolahdooz, F, Abedi, F, et al. (2016) Vitamin D supplementation affects the Beck Depression Inventory, insulin resistance, and biomarkers of oxidative stress in patients with major depressive disorder: a randomized, controlled clinical trial. J Nutr 146, 243–248. CrossRef | Google Scholar | PubMed
  • 35. Tarcin, O, Yavuz, DG, Ozben, B, et al. (2009) Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab 94, 4023–4030. CrossRef | Google Scholar | PubMed
  • 36. Radovic, J, Lazaravic, D, Nikolic, I, et al. (2012) Effect of alfacalcidol on oxidative stress and disease activity in JIA patients. Ann Paediatr Rheumatol 1, 126–132. CrossRef | Google Scholar
  • 37. Witham, MD, Adams, F, McSwiggan, S, et al. (2015) Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome – a randomised controlled trial. Nutr Metab Cardiovasc Dis 25, 287–294. CrossRef | Google Scholar | PubMed
  • 38. Nasri, K, Akrami, S, Rahimi, M, et al. (2017) The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Endocr Res 43, 1–10. CrossRef | Google Scholar | PubMed
  • 39. Karamali, M, Beihaghi, E, Mohammadi, AA, et al. (2015) Effects of high-dose vitamin D supplementation on metabolic status and pregnancy outcomes in pregnant women at risk for pre-eclampsia. Horm Metab Res 47, 867–872. Google Scholar | PubMed
  • 40. European Food Safety Authority (2016) Draft Scientific Opinion. Scientific Opinion on Dietary Reference Values for Vitamin D. EFSA Journal. https://www.efsa.europa.eu/sites/default/files/consultation/160321.pdf (accessed September 2018). Google Scholar

Created by admin. Last Modification: Monday February 25, 2019 01:48:31 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
10706 Oxidative book.jpg admin 18 Oct, 2018 14:21 23.85 Kb 1462
10705 Oxidative stress.jpg admin 18 Oct, 2018 14:20 40.82 Kb 3713
See any problem with this page? Report it (FINALLY WORKS)