Loading...
 
Toggle Health Problems and D

Influenza Vaccination not benefited by lowish levels of vitamin D – meta-analysis March 2018

Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis

Nutrients 2018, 10(4), 409; doi:10.3390/nu10040409 (registering DOI)

 Download the PDF from VitaminDWiki

Ming-Dar Lee 1,†, Chao-Hsu Lin 1,†, Wei-Te Lei 1, Hung-Yang Chang 2, Hung-Chang Lee 2, Chun-Yan Yeung 2, Nan-Chang Chiu 2, Hsin Chi 2, Jui-Ming Liu 3,4,5, Ren-Jun Hsu 3, Yu-Jyun Cheng 1, Tzu-Lin Yeh 1OrcID and Chien-Yu Lin 1,* OrcID

Influenza virus infection is a major global public health problem, and the efficacy of influenza vaccination is not satisfactory. Vitamin D is involved in many immune-mediated inflammatory processes. The impact of vitamin D levels on the immunogenic response to influenza vaccination is not clear. We performed a comprehensive literature search and systematic review of studies that investigated vitamin D and influenza vaccination. Data pertaining to study population, vaccine components, vitamin D levels, and immunogenic response were analyzed. Nine studies, with a combined study population of 2367 patients, were included in the systematic review. Four studies were included in the meta-analysis to investigate the influence of vitamin D deficiency (VDD) on the seroprotection (SP) rates and seroconversion (SC) rates following influenza vaccination. We found no significant association between vitamin D level and the immunogenic response to influenza vaccination. However, strain-specific differences may exist. We observed lower SP rates of influenza A virus subtype H3N2 (A/H3N2) and B strain in VDD patients than patients with normal vitamin D levels (A/H3N2: 71.8% vs. 80.1%, odds ratio (OR): 0.63, 95% confidence interval (CI): 0.43–0.91, p = 0.01; B strain: 69.6% vs. 76.4%, OR: 0.68, 95% CI: 0.5–0.93, p = 0.01). However, the SP rates of A/H1N1 and SC rates of all three strains were not significantly different in VDD and control groups. In conclusion, no association was observed between VDD and immunogenic response to influenza vaccination

Title change made March 2021 caused the visitor count to reset.
There have actually been 4776 visitors to this page since it was originally made


Created by admin. Last Modification: Sunday November 14, 2021 03:05:16 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
9580 Influenza Vaccination meta.pdf admin 26 Mar, 2018 366.98 Kb 665