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Infections and low vitamin D


Fact Many infections are associated with low vitamin D

Fact Many infections are treated by Vitamin D

Fact Many infections are prevented by higher levels of Vitamin D

Apparently Low vitamin D levels are both a cause and a result of severe infections
Unknown Can Vitamin D treat and prevent Deep Neck Infections?
Unknown Does the Vitamin D Receptor or other genes limit vitamin D from getting to deep neck tissues

Immunity category which starts with

221 items in Immunity category

    see also

Virus category listing has 835 items along with related searches

Overview Influenza and vitamin D
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
141 VitaminDWiki pages contained "infection" in title (June 2021)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021 nothing about Vitamin D
13 titles in VitaminDWiki contained INNATE or ADAPTIVE as of July 2021
Increasing publications on vitamin D and Infection

34 studies are in both Immunity and Virus categories

141 Vitamin D pages contained "infection" in title (June 2021)

Items found: 155
Title Modified
COVID-19 infection risk 2X higher in vaccinated than previously infected (28,000 in Netherlands) – preprint Nov 24, 2021 02 Dec, 2021
3.3 X more likely to die if infected with SARS-Cov-2 plus a second pathogen – meta-analysis May 2021 17 Nov, 2021
COVID-19 Infection Rate Skyrockets in America’s Most Vaccinated State: Vermont - Nov 14, 2021 14 Nov, 2021
Nursing home vaccinated against Influenza, 800 IU of vitamin D daily cut infection rate in half – small RCT Oct 2021 04 Nov, 2021
After HIV infection, Vitamin D levels drop for years (not a surprise)– Oct 2021 26 Oct, 2021
Viral respiratory infections reduced by both Vitamin D and Zinc – meta-analysis -Oct 2021 11 Oct, 2021
Respiratory viral infection (RSV) and low vitamin D - several studies 02 Oct, 2021
Enveloped virus infection (RSV, coronavirus, HIV, etc.) 1.5X more likely if poor Vitamin D Receptor – meta-analysis Dec 2018 02 Oct, 2021
Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews - Aug 2020 24 Sep, 2021
Respiratory Tract Infections during cold weather – similar rates for low and very low vitamin D – Sept 2021 24 Sep, 2021
Helicobacter pylori infection 11 X more likely if low vitamin D – meta-analysis Aug 2019 15 Sep, 2021
Urinary tract infection 5.4X more likely in girls if low Vitamin D – July 2021 12 Aug, 2021
8 of 10 pediatric COVID-19 infections were Vitamin D deficient (49 patients) – May 2021 08 Aug, 2021
Vitamin D for infections and COVID (50,000 IU weekly for 3 months) – July 2021 02 Aug, 2021
Chronic Hepatitis D viral infection 3.6 X more likely if low vitamin D – July 2021 24 Jul, 2021
Similar number of US deaths were associated with vaccinations as COVID-19 infections in the previous week– July 12, 2021 19 Jul, 2021
Infant Respiratory Infections not reduced by mothers taking small amount of vitamin D (28,000 weekly)– RCT July 2021 03 Jul, 2021
Bacterial infections reduced by Vitamin D without antibiotics – Oct 2019 24 Jun, 2021
Vitamin D may reduce Respiratory Tract Infections and the use of antibiotics – March 2021 24 Jun, 2021
Infections and low vitamin D 24 Jun, 2021
Little risk of infection after surgery if have more than 50 ng of vitamin D - 2014 30 May, 2021
Growing consensus: COVID-19 symptoms are due to infected blood vessels - April 2021 02 May, 2021
COVID-19 lung infection upsets Vitamin D genes (so more or different form of Vit D is required) - Dec 22, 2020 26 Apr, 2021
Vitamin D reduces Respiratory Tract Infections and reduces use of antibiotics – March 2021 15 Apr, 2021
Less COVID-19 infection, mortality in countries with higher Vitamin D (Asia in this case) – May 2021 07 Apr, 2021
Small vitamin D doses provide small benefits for acute respiratory infections – Meta-analysis March 2021 31 Mar, 2021
How much vitamin D is needed ( perhaps 50 ng for infections) 08 Mar, 2021
Vitamin D reduces viral respiratory infections – editorial April 18, 2020 02 Mar, 2021
Meningitis and other brain infections should be prevented by Vitamin D – June 2014 25 Feb, 2021
Long-haul fatigue, etc. common after viral infections (SARS1,2, MERS, Swine, 1918,...) 21 Feb, 2021
Vitamin D Help Us Fight Infections - interview of Dr. Thakkar (transcript) Jan 20, 2021 24 Jan, 2021
Respiratory Tract Infection risk reduced 2X by Vitamin D loading doses – meta-analysis Jan 2021 22 Jan, 2021
Acute respiratory tract infections not reduced by Vitamin D if already have a good level – Jan 2020 15 Jan, 2021
Upper Respiratory Tract Infections in adults reduced by just 400 IU of vitamin D – RCT Dec 2020 12 Dec, 2020
19X fewer COVID-19 infections if innate immune system activated – trial Oct 21, 2020 21 Nov, 2020
20,000 COVID-19 infections at Amazon (far less than US average of 34,000) – Oct 1, 2020 02 Oct, 2020
Sleep Apnea patients are 5X more likely to have a COVID-19 infection requiring hospitalization - Sept 28, 2020 29 Sep, 2020
Vaccination increased risk of getting (previous) Coronavirus infection by 1.36 X – Dept. of Defense Oct 2019 23 Sep, 2020
Low vitamin D with HIV increases risk of infections – TB by 3.5X, CMV by 10.1X – Aug 2020 14 Aug, 2020
Zinc, respiratory tract infections and COVID-19 – July 2020 07 Jun, 2020
Vitamin D Supplements Could Reduce Risk of Influenza and COVID-19 Infection and Death - April 9, 2020 07 Apr, 2020
Immunity against infection: letter sent to the editor of The Times UK - April 6, 2020 06 Apr, 2020
Viral infection wheezing 24X more likely if less than 15 ng of Vitamin D – Dec 2019 04 Apr, 2020
COVID-19 infections associated with very low vitamin D – Turin Italy – March, 2020 30 Mar, 2020
Vitamin D supplementation could prevent and treat influenza, CORONAVIRUS, and pneumonia infections - March 2020 30 Mar, 2020
COVID19 model of infections and deaths made for China applied to Italy – March 15, 2020 23 Mar, 2020
Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018 10 Mar, 2020
China Coronavirus update -64 percent of healthcare workers infected, etc, – JAMA Feb 24, 2020 08 Mar, 2020
Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020 07 Mar, 2020
Four of the 7 types of human Coronavirus only cause mild respiratory infections 04 Feb, 2020

Are Vitamin D Levels Associated With Risk of Deep Neck Infection? - Sept 2019

Ear Nose and Throat Journal https://doi.org/10.1177/0145561319865498
Mustafa Sıtkı Gozeler, MD, Muhammed Sedat Sakat, MD, Korhan Kilic, MD, ...

 Download the PDF from VitaminDWiki

Deep neck infection (DNI) refers to infections in spaces created by superficial and deep cervical fascia around the muscles and organs in the neck. Vitamin D is highly important for an effective immune system. Vitamin D receptors (VDR) have been identified in immune system cells, and particularly in T and B lymphocytes, macrophages, and dendritic cells. Vitamin D deficiency is thought to result in impaired immune response, decreased leukocyte chemotaxis, and an increased disposition to infection. The purpose of this study was to investigate whether vitamin D deficiency is an underlying occult factor in the development of DNI. Sixty-five patients aged 6 to 90, diagnosed with DNI, and 70 healthy age- and sex-compatible cases were included in the study. Serum levels of calcium, phosphorus, parathyroid hormone, and 25-hydroxy vitamin D (25(OH)D) were determined in each case. 25-hydroxy vitamin D levels above 20 ng/mL were regarded as normal, 12 to 20 ng/mL as insufficient, 5 to 12 ng/mL as deficient, and less than 5 ng/mL as severely deficient.
Mean serum 25(OH)D levels were

  • 10.4 (6.2) ng/mL in the patient group and
  • 15.5 (6.4) ng/mL in the control group (P < .01).

This difference was statistically significant (P < .01). Vitamin D was within normal limits in 9.2% (n = 6) of cases in the study group, insufficient in 29.2% (n = 19), deficient in 35.3% (n = 23), and severely deficient in 26.2% (n = 17). The equivalent values in the control group were 21.4% (n = 15), 48.5% (n = 34), 30% (n = 21), and 0% (n = 0). Serum 25(OH)D levels were significantly lower in patients with DNI compared to the healthy cases; 25(OH)D levels may be a factor in the development of DNI.

Deep neck infections: A single-center analysis of 63 cases - Sept 2017

Med Oral Patol Oral Cir Bucal. 2017 Sep; 22(5): e536–e541, online 2017 Aug 16. doi: 10.4317/medoral.21799
Philipp Kauffmann,corresponding author1 Robert Cordesmeyer,1 Markus Tröltzsch,1 Christian Sömmer,1,2 and Rainer Laskawi3

Background and Purpose
With the use of antibiotic therapy, the incidence of deep neck infections has decreased in recent decades. The aim of this investigation was to review the clinical course and the management of deep neck infections in our department, compare them to the experiences of the common literature and identify predisposing factors for lethal complications.

Material and Methods
In this single-center analysis, 63 patients with deep neck infections were treated surgically. The following clinical data were analyzed and compared: age, gender, laboratory data, spatial manifestation, therapeutic modalities, comorbidities, length of hospitalization and complications.

There was a predominance of male patients (58.7%) and a mean age of 57.9 years. The most common symptoms at diagnosis were sore throat (96.8%) and neck swelling (92.0%). Cardio/pulmonary diseases and diabetes mellitus were the most common comorbidities. There was a significantly longer hospital stay for patients with diabetes mellitus. The most common manifestation was a parapharyngeal abscess in 24 patients (38.1%), followed by peri-/retrotonsillar infections in 19 patients (30.2%). In 29 patients, a multiple space infection was observed, with a significantly longer duration of hospitalization and a higher rate of complications. The main life-threatening complication was the development of airway obstruction in 20 patients (31.7%), who all received a tracheostomy. The duration of hospitalization for patients with complications was significantly longer.

Close attention must be paid to the management of patients with deep neck infections, especially patients with diabetes mellitus and cardio/pulmonary diseases or patients with multiple space infections.

 Download the PDF from VitaminDWiki

Deep Neck Infection Symptoms - Sept 2017

# of infections with a symptom (not %)

Created by admin. Last Modification: Thursday June 24, 2021 17:29:29 GMT-0000 by admin. (Version 23)

Attached files

ID Name Comment Uploaded Size Downloads
12760 DNI symptoms.jpg admin 08 Oct, 2019 14:39 33.75 Kb 1142
12759 DNI Sept 2017.pdf admin 08 Oct, 2019 14:39 448.96 Kb 518
12758 DNI levels.jpg admin 08 Oct, 2019 14:17 18.32 Kb 1190
12757 DNI.pdf PDF 2019 admin 08 Oct, 2019 14:17 113.00 Kb 484
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