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Implanting titanium in mice helped by vitamin D: wonder about human teeth, hips etc. – April 2014

Vitamin d supplementation enhances the fixation of titanium implants in chronic kidney disease mice.

PLoS One. 2014 Apr 21;9(4):e95689. doi: 10.1371/journal.pone.0095689. eCollection 2014.
Liu W1, Zhang S1, Zhao D1, Zou H1, Sun N1, Liang X1, Dard M2, Lanske B3, Yuan Q1.
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Vitamin D (Vit D) deficiency is a common condition in chronic kidney disease (CKD) patients that negatively affects bone regeneration and fracture healing. Previous study has shown that timely healing of titanium implants is impaired in CKD. This study aimed to investigate the effect of Vit D supplementation on implant osseointegration in CKD mice. Uremia was induced by 5/6 nephrectomy in C57BL mice. Eight weeks after the second renal surgery, animals were given 1,25(OH)2D3 three times a week intraperitoneally for four weeks. Experimental titanium implants were inserted into the distal end of femurs two weeks later. Serum measurements confirmed decreased 1,25(OH)2D levels in CKD mice, which could be successfully corrected by Vit D injections. Moreover, the hyperparathyroidism observed in CKD mice was also corrected. X-ray examination and histological sections showed successful osseointegration in these mice. Histomorphometrical analysis revealed that the bone-implant contact (BIC) ratio and bone volume (BV/TV) around the implant were significantly increased in the Vit D-supplementation group. In addition, resistance of the implant, as measured by a push-in method, was significantly improved compared to that in the vehicle group. These results demonstrate that Vit D supplementation is an effective approach to improve the fixation of titanium implants in CKD.

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PMID: 24752599

PDF is attached at the bottom of this page

VitaminDWiki observation
Chronic Kidney disease is associated with low vitamin D
It appears that the active vitamin D supplementation allows the body to heal it self much more quickly
Perhaps vitamin will help with healing/integration with titanium in humans as well who are low on vitamin D - such as hip surgery

See also VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
3834 F5.jpg admin 23 Apr, 2014 13:49 25.45 Kb 596
3833 F4.jpg admin 23 Apr, 2014 13:49 47.24 Kb 551
3832 Titanium F2.jpg admin 23 Apr, 2014 13:35 43.35 Kb 606
3831 Vitamin d supplementation enhances the fixation.pdf PDF 2014 admin 23 Apr, 2014 13:32 146.08 Kb 499
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