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Immune system is helped by vitamin D via dendritic cells – Sept 2015

Regulation of Dendritic Cell Function by Vitamin D

Nutrients 2015, 7(9), 8127-8151; doi:10.3390/nu7095383 (registering DOI)


Myriam Barragan 1,2,3,†, Misty Good 1,3,4,† and Jay K. Kolls 1,3,*
1 Richard King Mellon Foundation Institute for Pediatric Research, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
2 Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
3 Department of Pediatrics, School of Medicine, University of Pittsburgh Pittsburgh, PA 15224, USA
4 Division of Newborn Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, USA
Received: 29 July 2015 / Revised: 4 September 2015 / Accepted: 10 September 2015 / Published: 21 September 2015
(This article belongs to the Special Issue Immune Regulation by Vitamin D)

Studies over the last two decades have revealed profound immunomodulatory aspects of vitamin D on various aspects of the immune system. This review will provide an overview of Vitamin D metabolism, a description of dendritic cell subsets, and highlight recent advances on the effects of vitamin D on dendritic cell function, maturation, cytokine production and antigen presentation. The active form of vitamin D, 1,25(OH)2D3, has important immunoregulatory and anti-inflammatory effects. Specifically, the 1,25(OH)2D3-Vitamin D3 complex can affect the maturation and migration of many dendritic cell subsets, conferring a special immunoregulatory role as well as tolerogenic properties affecting cytokine and chemokine production. Furthermore, there have been many recent studies demonstrating the effects of Vitamin D on allergic disease and autoimmunity. A clear understanding of the effects of the various forms of Vitamin D will provide new opportunities to improve human health.

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  • (https://en.wikipedia.org/wiki/Dendritic_cell|Dendritic Cell ] Wikipedia Nov 2016
    "They act as messengers between the innate and the adaptive immune systems."

Attached files

ID Name Comment Uploaded Size Downloads
5949 Active D and inflammation.jpg admin 21 Sep, 2015 12:45 36.04 Kb 3448
5948 DC VDR.jpg admin 21 Sep, 2015 12:45 32.11 Kb 2449
5947 Dendritic Cell Function.pdf PDF 2015 admin 21 Sep, 2015 12:44 941.70 Kb 346
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