An inverse association between magnesium in 24h urine
and cardiovascular risk factors in middle-aged subjects in 50 CARDIAC Study populations.
Hypertens Res. 2014 Oct 30. doi: 10.1038/hr.2014.158. [Epub ahead of print]
Yamori Y1, Sagara M2, Mizushima S3, Liu L4, Ikeda K5, Nara Y6.
4211 women in 22 countries
Those having enough Mg to excrete extra to urine had
- lower total cholesterol
- lower BMI
- lower blood pressure
Serum, plasma and dietary magnesium (Mg) have been reported to be inversely associated with cardiovasculardisease risk factors. We examined the associations between the 24-h urinary Mg/creatinine (Cre) ratio and cardiovascular disease risk factors, such as body mass index (BMI), blood pressure (BP), serum total cholesterol (TC) and prevalence of obesity, hypertension and hypercholesterolemia. A cross-sectional analysis was conducted among 4211 participants (49.7% women) aged 48-56 years in 50 population samples from 22 countries in the World Health Organization-coordinated Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study (1985-1994).
In linear regression analyses, Mg/Cre ratio was inversely associated with
- systolic BP (SBP),
- diastolic BP (DBP) and
- TC (P for linear trend <0.001 for each).
These associations were not markedly altered by adjustment for traditional risk factors, urinary markers or cohort effects. Multivariate-adjusted mean values for the subjects in the highest Mg/Cre ratio quintile were 6.3, 3.4, 5.3 and 4.6% lower than those for the subjects in the lowest quintile for BMI, SBP, DBP and TC (P<0.001, respectively).
The prevalence of obesity, hypertension and hypercholesterolemia was 2.10 (95% confidence interval: 1.50, 2.95), 1.55 (1.25, 1.92) and 2.06 (1.63, 2.62) times higher (P<0.001, respectively) among the subjects in the lowest Mg/Cre ratio quintile than in the subjects in the highest quintile.
These associations were not appreciably altered by adjustment for potential confounding variables. In conclusion, higher 24-h urinary Mg/Cre ratio was associated with lower cardiovascular disease risk factors, including BMI, BP, TC, obesity, hypertension and hypercholesterolemia.
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