Hyperparathyroidism resulting from CKD eliminated by 8,000 IU of vitamin D daily for 12 weeks– RCT 2018

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High doses of cholecalciferol alleviate the progression of hyperparathyroidism in patients with CKD Stages 3–4: results of a 12-week double-blind, randomized, controlled study

Nephrol Dial Transplant (2018) 33: 466–471 doi: 10.1093/ndt/gfx059
Per-Anton Westerberg1,2, Gunnar Sterner3, Osten Ljunggren € 1, Elin Isaksson3, Fjo¨lnir Elvarson1,
Hamid Dezfoolian4 and Torbjo¨rn Linde1

Background. Calcidiol insufficiency may accelerate the development of secondary hyperparathyroidism (SHPT). We
tested the effect of a substantial increase in calcidiol on mineral metabolism in patients with chronic kidney disease (CKD).

Methods. Ninety-five patients with CKD Stages 3–4, parathyroid hormone (PTH) above 6.8 pmol/L and calcidiol below 75 nmol/L were randomized to receive either cholecalciferol 8000 IU/day or placebo for 12 weeks. The primary endpoint was difference in the mean change in iPTH after 12 weeks. The proportion of participants having a 30% reduction in PTH and the effect on hand grip strength, fatigue and different biochemical variables were also investigated.

Results. Baseline calcidiol was 57.5 6 22 and 56.8 6 22 nmol/L in the cholecalciferol and placebo groups, respectively. The corresponding concentrations of PTH were 10.9 6 5 and 13.1 6 9 pmol/L. Calcidiol increased to 162 6 49 nmol/L in patients receiving cholecalciferol, and PTH levels remained constant at 10.5 6 5 pmol/L. In the placebo group, calcidiol remained stable and PTH increased to 15.2 6 11 pmol/L. The mean change in PTH differed significantly between the two groups (P < 0.01). The proportion of subjects reaching a
30% decrease in PTH did not differ. No effect on grip strength, fatigue, phosphate or fibroblast growth factor 23 was observed. Cholecalciferol treatment resulted in stable calcium concentrations and a substantial increase in calcitriol

Conclusion. Treatment with high daily doses of cholecalciferol in patients with CKD Stages 3–4 halts the progression of SHPT and does not cause hypercalcaemia or other side effects.
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VitaminDWiki - Kidney category contains

Kidney category listing has 221 items

see also Overview Kidney and vitamin D
Peritoneal dialysis in titles in VitaminDWiki (3 titles as of Oct 2021)
CKD or CHRONIC KIDNEY DISEASE in title of 65 pages as of Dec 2022

• Kidney Inflammation not reduced by 30 ng Vitamin D (many health problems need 50 ng) – Nov 2022
• Chronic Kidney Disease decreases Vitamin D in 4 ways – Nov 2017
• Half as much chronic kidney disease infection if supplement with Vitamin D – 2018
• 2.4 times more likely to die if have Chronic Kidney Disease and low vitamin D - Sept 2016
• 4X more Chronic Kidney disease patients are now using vitamin D – March 2014
• Poor kidneys rarely get enough or the right form of vitamin D – Feb 2019

Calcitriol category listing has 56 items along with related searches

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VitaminDWiki - Overview Kidney and vitamin D contains

• FACT: The Kidneys are not the primary way to activate vitamin D; the tissues are
• FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
• FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
• FACT: There are many ongoing intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
• FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
• FACT: 38% of seniors have Chronic Kidney Disease and most are unaware of it CDC statistics 2020
• FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
• Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
    Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
  Nanoemulstion vitamin D (inside cheek, topically) gets activated Vitamin D to the cells without the need for healthy kidney, liver, or intestine
  Calcitriol - which bypasses the need for the kidney to activate vitamin D
    Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
      Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
• Category Kidney and Vitamin D contains 221 items

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VitaminDWiki - Chronic Kidney Disease reduced with 3600 IU vitamin D (50000 twice a month)– RCT Aug 2012