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High vs low Vitamin B12 levels associated with 1.7 X increased risk of death – Jan 2020

Association of Plasma Concentration of Vitamin B12 With All-Cause Mortality in the General Population in the Netherlands

JAMA Netw Open. 2020;3(1):e1919274. doi:10.1001/jamanetworkopen.2019.19274

VitaminDWiki

Adults - average age 53, - exluded those getting B12 injections
Only 4% died after 7.5 years - but 1.7 X higher risk of death if high B2

Vitamin B12 category listing has 42 items and includes:
  • B12 use both before and during Breast Cancer chemotherapy decreased survival by 1.8 X - 2019
  • WARNING: High intake of B12 and B6 found to increase risk of hip fracture by 47 percent - 2019

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Jose L. Flores-Guerrero, MD, MSc1; Isidor Minović, PhD1,2; Dion Groothof, BSc1; et alEke G. Gruppen, MSc1; Ineke J. Riphagen, PhD2; Jenny Kootstra-Ros, PhD2; Anneke Muller Kobold, PhD2; Eelko Hak, PhD3; Gerjan Navis, MD, PhD1; Ron T. Gansevoort, MD, PhD1; Martin H. de Borst, MD, PhD1; Robin P. F. Dullaart, MD, PhD4; Stephan J. L. Bakker, MD, PhD1

  • Question Are plasma concentrations of vitamin B12 associated with risk of all-cause mortality among adults from the general population of the Netherlands?
  • Findings In this population-based cohort study including 5571 adults, higher plasma concentrations of vitamin B12 were associated with a 25% increased adjusted risk of all-cause mortality per 1-SD increase.
  • Meaning These findings suggest that higher plasma concentrations of vitamin B12 are associated with all-cause mortality, independent of traditional risk factors.

Importance Higher plasma concentrations of vitamin B12 have been associated with mortality in elderly and hospitalized populations, including patients with chronic kidney disease, but the association of plasma concentrations of vitamin B12 with mortality in the general population remains unclear.

Objective To investigate the association of plasma concentrations of vitamin B12 with all-cause mortality.

Design, Setting, and Participants This longitudinal cohort study used post hoc analysis to examine data from participants of the Prevention of Renal and Vascular End-stage Disease Study in Groningen, the Netherlands. Participants included individuals who completed the second screening visit beginning January 1, 2001, excluding those who were missing values of vitamin B12 plasma concentrations or used vitamin B12 supplementation. Follow-up time was defined between the beginning of the second screening round to end of follow-up on January 1, 2011. Data analysis was conducted from October 2, 2018, to February 22, 2019.

Exposures Plasma vitamin B12 concentration level.

Main Outcomes and Measures Death as recorded by the Central Bureau of Statistics of Groningen, the Netherlands.

Results A total of 5571 participants (mean [SD] age, 53.5 [12.0] years; 2830 [50.8%] men) were included in analyses. Median (interquartile range) plasma concentration of vitamin B12 was 394.42 (310.38-497.42) pg/mL. During the median (interquartile range) of 8.2 (7.7-8.9) years of follow-up, 226 participants (4.1%) died. According to quartiles of the distribution of plasma vitamin B12 concentration levels, mortality rates were 33.8 deaths per 10 000 person-years for the quartile with the lowest plasma concentration of vitamin B12 and 65.7 deaths per 10 000 person-years for the quartile with the highest plasma concentration of vitamin B12. After adjustment for multiple clinical and laboratory variables, Cox regression analyses found a significant association between higher vitamin B12 plasma concentration level and increased risk of all-cause mortality (hazard ratio per 1-SD increase, 1.25 [95% CI, 1.06-1.47]; P = .006).

Conclusions and Relevance These findings suggest that higher levels of plasma concentrations of vitamin B12 were associated with increased risk of all-cause mortality after adjusting for age, sex, renal function, and other clinical and laboratory variables. The mechanisms underlying this association remain to be established.


Created by admin. Last Modification: Thursday January 16, 2020 03:18:55 GMT-0000 by admin. (Version 8)

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13349 B12 mortality chart Q1 thru Q4.jpg admin 16 Jan, 2020 02:39 37.86 Kb 253
13348 B12 mortality chart.jpg admin 16 Jan, 2020 02:39 36.03 Kb 280
13347 B12 mortality Q4 vs Q1.jpg admin 16 Jan, 2020 02:38 36.30 Kb 315
13346 B12 higher, mortality higher.pdf PDF 2020 admin 16 Jan, 2020 02:38 1.08 Mb 90
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