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Heart Failure is predicted by PTH (but vitamin D both prevents and treats HF) – Jan 2018

The Role of Parathyroid Hormone and Vitamin D Serum Concentrations in Patients with Cardiovascular Diseases.

Dis Markers. 2018 Jan 31;2018:5287573. doi: 10.1155/2018/5287573. eCollection 2018.
Kolaszko A1, Nowalany-Kozielska E1, Ceranowicz P2, Morawiec B1, Kubiak G1.
1 2nd Department of Cardiology, Medical Faculty, Medical University of Silesia, Katowice 10 M. Skłodowskiej-Curie Street, 41-800 Zabrze, Poland.
2 Department of Physiology, Medical Faculty, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, Poland.

VitaminDWiki

Chronic Heart Failure not treated by Vitamin D, if dose size is ignored – meta-analysis Oct 2015
Risk of Cardiac failure reduced 20 percent by 800 IU of vitamin D and Calcium – meta-analysis July 2014
Chronic Heart Failure improved with 4,000 IU daily for a year – RCT April 2016
Seniors with Heart Failure helped by daily 4,000 IU of vitamin D (increase 16 ng) – RCT Aug 2014
Death in less than 2 years of Heart Failure associated with low vitamin D - April 2012
Heart Failure Quality of Life greatly improved by 10,000 IU of vitamin D – RCT Oct 2017
Heart failure among 137 seniors 12X more likely if low vitamin D – Aug 2017
PTH reduced 3.5 pmol by vitamin D intervention which added 22 ng – meta-analysis June 2014
Acute Heart Failure length of stay and readmission rates cut in half if high vitamin D – Aug 2017


Cardiovascular category starts with the following

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 Download the PDF from VitaminDWiki

25-hydroxyvitamin D (25(OH)D) plays a crucial role in human homeostasis. Its deficiency (vitamin D deficiency-VDD), being common in European population, combined with elevated concentration of parathyroid hormone (PTH), represents a vicious cycle of mechanisms leading to heart failure (HF). Despite several papers published in that field, the effect of VDD and PTH concentration on cardiovascular system remains unequivocal; thus, the aim of the study was to compare these data among HF and non-HF patients being prospectively enrolled into the study during hospital stay in the cardiology ward.
Patients with HF had higher PTH concentration (85.0 ± 52.6 versus 64.5 ± 31.7, p ≤ 0.02) compared to non-HF patients.
Image
Mean PTH values were associated with the clinical status expressed by the New York Heart Association class (NYHA class)

  • ("0"-66.04,
  • "I"-56.57,
  • "II"-72.30,
  • "III"-85.59, and
  • "IV"-144.37 pg/ml, p ≤ 0.00004).

Interestingly,

  • neither 25(OH)D (31.5 versus 29.7 ng/ml, p ≤ ns)
  • nor phosphorus (P) (1.23 versus 1.18 mmol/l, p ≤ ns)
  • nor total calcium (Ca2+) concentration (2.33 versus 2.37 mmol/l, p ≤ ns)

differed among the groups.
Reassuming PTH serum concentration in contrary to 25(OH)D, P and Ca2+ are significantly raised among the patients with HF and shows significant relationship with the clinical status expressed by the NYHA class.

PMID: 29599854 PMCID: PMC5831602 DOI: 10.1155/2018/5287573

Created by admin. Last Modification: Friday September 7, 2018 12:39:08 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
10498 PTH HF.jpg admin 07 Sep, 2018 12:24 31.21 Kb 94
9616 PTH better descriminator for HF.pdf PDF 2018 admin 31 Mar, 2018 18:31 1.79 Mb 61
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