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Heart Failure is predicted by PTH (but vitamin D both prevents and treats HF) – Jan 2018

The Role of Parathyroid Hormone and Vitamin D Serum Concentrations in Patients with Cardiovascular Diseases.

Dis Markers. 2018 Jan 31;2018:5287573. doi: 10.1155/2018/5287573. eCollection 2018.
Kolaszko A1, Nowalany-Kozielska E1, Ceranowicz P2, Morawiec B1, Kubiak G1.
1 2nd Department of Cardiology, Medical Faculty, Medical University of Silesia, Katowice 10 M. Skłodowskiej-Curie Street, 41-800 Zabrze, Poland.
2 Department of Physiology, Medical Faculty, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, Poland.

VitaminDWiki

Chronic Heart Failure not treated by Vitamin D, if dose size is ignored – meta-analysis Oct 2015
Risk of Cardiac failure reduced 20 percent by 800 IU of vitamin D and Calcium – meta-analysis July 2014
Chronic Heart Failure reduced by 4,000 IU daily for a year – RCT April 2016
Seniors with Heart Failure helped by daily 4,000 IU of vitamin D (increase 16 ng) – RCT Aug 2014
Death in less than 2 years of Heart Failure associated with low vitamin D - April 2012
Heart Failure Quality of Life greatly improved by 10,000 IU of vitamin D – RCT Oct 2017
Heart failure among 137 seniors 12X more likely if low vitamin D – Aug 2017
PTH reduced 3.5 pmol by vitamin D intervention which added 22 ng – meta-analysis June 2014
Acute Heart Failure length of stay and readmission rates cut in half if high vitamin D – Aug 2017


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 Download the PDF from VitaminDWiki

25-hydroxyvitamin D (25(OH)D) plays a crucial role in human homeostasis. Its deficiency (vitamin D deficiency-VDD), being common in European population, combined with elevated concentration of parathyroid hormone (PTH), represents a vicious cycle of mechanisms leading to heart failure (HF). Despite several papers published in that field, the effect of VDD and PTH concentration on cardiovascular system remains unequivocal; thus, the aim of the study was to compare these data among HF and non-HF patients being prospectively enrolled into the study during hospital stay in the cardiology ward.
Patients with HF had higher PTH concentration (85.0 ± 52.6 versus 64.5 ± 31.7, p ≤ 0.02) compared to non-HF patients.
Image
Mean PTH values were associated with the clinical status expressed by the New York Heart Association class (NYHA class)

  • ("0"-66.04,
  • "I"-56.57,
  • "II"-72.30,
  • "III"-85.59, and
  • "IV"-144.37 pg/ml, p ≤ 0.00004).

Interestingly,

  • neither 25(OH)D (31.5 versus 29.7 ng/ml, p ≤ ns)
  • nor phosphorus (P) (1.23 versus 1.18 mmol/l, p ≤ ns)
  • nor total calcium (Ca2+) concentration (2.33 versus 2.37 mmol/l, p ≤ ns)

differed among the groups.
Reassuming PTH serum concentration in contrary to 25(OH)D, P and Ca2+ are significantly raised among the patients with HF and shows significant relationship with the clinical status expressed by the NYHA class.

PMID: 29599854 PMCID: PMC5831602 DOI: 10.1155/2018/5287573


Created by admin. Last Modification: Friday September 7, 2018 12:39:08 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
10498 PTH HF.jpg admin 07 Sep, 2018 31.21 Kb 617
9616 PTH better descriminator for HF.pdf admin 31 Mar, 2018 1.79 Mb 429