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Heart Failure Quality of Life greatly improved by 10,000 IU of vitamin D – RCT Oct 2017

Vitamin D3 repletion versus placebo as adjunctive treatment of heart failure patient quality of life and hormonal indices: a randomized, double-blind, placebo-controlled trial.

BMC Cardiovasc Disord. 2017 Oct 30;17(1):274. doi: 10.1186/s12872-017-0707-y.
Moretti HD1, Colucci VJ2,3, Berry BD4,2.
1 Providence Saint Patrick Hospital, 500 W. Broadway St, Missoula, MT, 59802, USA. heidi.moretti at providence.org.
2 International Heart Institute of Montana, 500 W. Broadway, Missoula, MT, 59802, USA.
3 University of Montana, 32 Campus Drive, Missoula, MT, 59812, USA.
4 Providence Saint Patrick Hospital, 500 W. Broadway St, Missoula, MT, 59802, USA.


10,000 IU of Vitamin D daily for 6 months raised levels by 49 ng

Cardiovascular category starts with the following

440 items In Cardiovascular category

Meta-analyses (auto-updated)

Omega-3 Helps (auto-updated)

A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues

Cholesterol, Statins

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Note: Kansas City Cardiomyopathy Questionnaire ranges from 0 (worst, with poor chance of survival) to 100

Vitamin D status may influence heart failure (HF) patient outcomes by affecting b-type natriuretic peptide (BNP), parathyroid hormone (PTH), and enhancing cardiac contractility. Vitamin D deficiency is associated with morbidity and mortality in HF patients. The objective of this study was to determine if vitamin D3 at a comparatively high dose would replete 25-hydroxyvitamin D (25(OH)D) stores, improve BNP, PTH, cardiopulmonary function, reduce inflammatory markers, and improve quality of life (QOL) in HF patients.

This was a 6 month, parallel group, double-blind, placebo-controlled, single clinic center, randomized trial of supplemental vitamin D3 using a dose of 10,000 IU daily or placebo in 40 vitamin D deficient or insufficient (25(OH)D level ≤ 32 ng/ml) patients with stable New York Heart Association Class II-III HF in a specialty cardiology clinic. All variables were measured at baseline and 6 months. Values between the two treatment groups were assessed using Student's t-test or Mann-Whitney Test. Univariate analysis of covariance was conducted to adjust for variance in baseline 25(OH)D.

All results were adjusted for baseline 25(OH)D. The change in BNP from baseline was ∆ +30 ± 950 pg/ml for treatment vs. placebo ∆ +400 ± 1900 pg/ml, p = 0.003. 25(OH)D serum levels rose by 49 ± 32 ng/ml in the treatment group vs 4 ± 10 ng/ml in the placebo group, p < 0.001. PTH and exercise chronotropic response index improved in the treatment group vs placebo group, respectively, but both were attenuated by adjustment ( (∆-20 ± 20 pg/ml vs ∆ + 7 ± 53 pg/ml respectively (p = 0.01, adjusted p = 0.07)) and (∆ + 0.13 ± 0.26 vs. ∆-0.03 ± 02.9 respectively, p < 0.01, adjusted p = 0.17)). Other measured cardiopulmonary parameters remained unchanged. High sensitivity C-reactive protein (hsCRP) remained unchanged for women, but improved for men (∆-2 ± 4 treatment versus ∆2 ± 5 mg/L placebo, p = 0.05).
QOL scores, including composite overall and clinical summary scores significantly improved in treatment compared to placebo (∆ + 10 ± 15 versus -6 ± 15, p < 0.01 and ∆ + 8 ± 14 versus -8 ± 18, p = 0.01, respectively).

Repletion of 25(OH)D may improve QOL in HF patients and may help to normalize BNP, PTH, and hsCRP.

TRIAL REGISTRATION: Clinicaltrials.gov, NCT01636570 , First registered 3 July 2012.

PMID: 29084522 DOI: 10.1186/s12872-017-0707-y

Review of Study by Vitamin D Council

Created by admin. Last Modification: Monday November 13, 2017 17:03:55 GMT-0000 by admin. (Version 8)

Attached files

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8620 QoL Heart Failure 10,000 IU.jpg admin 01 Nov, 2017 11:16 19.75 Kb 401
8619 Heart failure QoL 10,000 IU.pdf PDF 2017 admin 01 Nov, 2017 11:15 730.52 Kb 414
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