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Heart Failure with depression increases risk of death by 9.5 X if low vitamin D – Aug 2017

Vitamin D supplements reduce depressive symptoms and cardiac events in heart failure patients with moderate to severe depressive symptoms.

Eur J Cardiovasc Nurs. 2017 Aug 1:1474515117727741. doi: 10.1177/1474515117727741. [Epub ahead of print]

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Study is available at SciHub and at the bottom of this page

Song EK1, Wu JR2, Moser DK3, Kang SM4, Lennie TA3.
1 Department of Nursing, University of Ulsan, Korea.
2 School of Nursing, University of North Carolina at Chapel Hill, USA.
3 College of Nursing, University of Kentucky, USA.
4 Cardiology Division, Severance Hospital, Yonsei Cardiovascular Center and Cardiovascular Research Institute, Korea.

Death of CF patients with moderate to severe depression

Image
Note Adequate is defined by this study as > 400 IU from dietary sources
Far greater separation of variables on the chart expected if blood test measurements had been used

BACKGROUND:
Depressive symptoms and vitamin D deficiency predict cardiac events in heart failure patients, but whether vitamin D supplements are associated with depressive symptoms and cardiac events in heart failure patients remains unknown.

PURPOSE:
The purpose of this study was to compare the association of vitamin D supplement use with depressive symptoms and cardiac events in heart failure patients with mild or moderate to severe depressive symptoms.

METHODS:
A total of 177 heart failure patients with depressive symptoms (Patient Health Questionnaire-9 score ≥5) completed a three-day food diary to determine dietary vitamin D deficiency. Patients were split into four groups by dietary vitamin D adequacy versus deficiency and vitamin D supplement use versus non-use. The Patient Health Questionnaire-9 was used to reassess depressive symptoms at six months. Data on cardiac events for up to one year and vitamin D supplement use were obtained from patient interview and medical record review. Hierarchical linear and Cox regressions were used for data analysis.

RESULTS:
Sixty-six patients (37.3%) had dietary vitamin D deficiency and 80 (45.2%) used vitamin D supplements. In patients with moderate to severe depressive symptoms, the group with dietary vitamin D deficiency and no supplements had the highest Patient Health Questionnaire-9 score at six months (β=0.542, p<0.001) and shortest cardiac event-free survival ( p<0.001) among the four groups, the group with dietary vitamin D deficiency and no supplements didn't have the highest Patient Health Questionnaire-9 score at six months and shortest cardiac event-free survival in patients with mild depressive symptoms.

CONCLUSIONS:
Vitamin D supplements predicted lower depressive symptoms and reduced cardiac events for patients with moderate to severe depressive symptoms. Vitamin D deficiency was associated with higher risk of shorter cardiac event-free survival in heart failure patients regardless of vitamin D supplementation.

PMID: 28829157 DOI: 10.1177/1474515117727741


Created by admin. Last Modification: Wednesday August 23, 2017 19:05:28 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
8340 Depression and Heart Failure.pdf admin 23 Aug, 2017 483.15 Kb 272
8339 Cardiac Event.jpg admin 23 Aug, 2017 25.47 Kb 490