Vitamin D Deficiency in Patients With Chronic Tension-Type Headache: A Case-Control Study
Headache: Journal of Head and Face Pain, First published: 3 May 2017, DOI: 10.1111/head.13096
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Reviewed at Vitamin D Council
Chronic tension headache may be a symptom of vitamin D deficiency May 2017
Publisher rents the PDF for $6
Sanjay Prakash DM (Neurology), drprakashs at yahoo.co.in, Chaturbhuj Rathore DM (Neurology),
Prayag Makwana DM (Neurology), Ankit Dave DM (Neurology),
Hemant Joshi DM (Neurology),Haresh Parekh DM (Neurology)
Objective: To see the interrelation between chronic tension-type headache (CTTH) and serum vitamin D levels.
Background: Several studies have suggested an association between chronic pain and vitamin D deficiency. Anecdotal evidence suggests that vitamin D deficiency may be associated with tension-type headache and migraine.
Methods: This case-control study was carried out to examine the association between CTTH and serum 25-hydroxy vitamin (25(OH) D) levels. One hundred consecutive adult (>18 years) patients with CTTH and 100 matched healthy controls were enrolled.
Results: The serum 25(OH) D levels were significantly lower in CTTH patients than in the controls (14.7 vs 27.4 ng/mL).
The prevalence of vitamin D deficiency (serum 25 (OH) D < 20 ng/mL) was greater in patients with CTTH (71% vs 25%). [2.8 X]
CTTH patients had a significantly high prevalence of
- musculoskeletal pain (79% vs 57%),
- muscle weakness (29% vs 10%), [2.9 X]
- muscle tenderness score (7.5 vs 1.9), and [3.9 X]
- bone tenderness score (3.0 vs 0.8) in comparison to controls. [3.8 X]
CTTH patients with vitamin D deficient group (<20 ng/mL) had a higher prevalence of
- musculoskeletal pain (58% vs 31%),
- muscle weakness (38% vs 7%), [5.4 X]
- muscle and bone tenderness score,
- associated fatigue (44% vs 17%) and
- more prolonged course (15.5 months vs 11.2 months).
A strong positive correlation was noted between serum vitamin D levels and total muscle tenderness score (R2 = 0. 7365) and total bone tenderness score (R2 = 0. 6293).
Conclusion: Decreased serum 25(OHD) concentration was associated with CTTH. Intervention studies are required to find out if supplementation of vitamin D is effective in patients with CTTH.
Review of Study in Neurology Today - Sept 2017
“Ultimately we're going to need a large-scale vitamin D intervention study to look for outcomes.”Headaches (chronic tension) 3X more likely to have low vitamin D – also muscle weakness and bone tenderness – May 2017
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