Toggle Health Problems and D

Gut is helped by Vitamin D – Sept 2017

The endocrine vitamin D system in the gut

Molecular and Cellular Endocrinology, Volume 453, 15 September 2017, Pages 79-87


Overview Gut and vitamin D contains the following summary

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 182 items

Gut category listing contains the following

182 items in GUT category - see also Overview Gut and vitamin D, See also Microbiome category listing has 27 items along with related searches.

• Gut expresses a high level of vitamin D receptor and is a main target of vitamin D.
• Vitamin D is a major responsible for intestinal Ca2+ and phosphate absorption.
• Vitamin D induces gut epithelial barrier function and defense against pathogens.
• Vitamin D deficiency is linked to inflammatory bowel diseases.
• Vitamin D deficiency is linked to an increased risk of colorectal cancer.

The active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) has important regulatory actions in the gut through endocrine and probably also intracrine, autocrine and paracrine mechanisms. By activating the vitamin D receptor (VDR), which is expressed at a high level in the small intestine and colon, 1,25(OH)2D3 regulates numerous genes that control gut physiology and homeostasis. 1,25(OH)2D3 is a major responsible for epithelial barrier function and calcium and phosphate absorption, and the host's defense against pathogens and the inflammatory response by several types of secretory and immune cells. Moreover, recent data suggest that 1,25(OH)2D3 has a regulatory effect on the gut microbiota and stromal fibroblasts. Many studies have linked vitamin D deficiency to inflammatory bowel diseases (ulcerative colitis and Crohn's disease) and to an increased risk of colorectal cancer, and the possible use of VDR agonists to prevent or treat these diseases is receiving increasing interest.

Keywords: Vitamin D Gut homeostasis Inflammatory bowel diseases Gut microbiota Colorectal cancer

Publisherwants $36 for the PDF

It can also be viewed at DeepDyve

How Vitamin D improves the gut and reduces colon cancer (CRC)


Created by admin. Last Modification: Thursday January 4, 2018 19:38:09 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
8963 Gut and CRC.jpg admin 19 Dec, 2017 11:20 56.07 Kb 494
See any problem with this page? Report it (WORKS NOV 2021)