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Gene which predicts wheezing is associated with low vitamin D – Oct 2019

Acute wheeze-specific gene module shows correlation with vitamin D and asthma medication.

Eur Respir J. 2019 Oct 16. pii: 1901330. doi: 10.1183/13993003.01330-2019.
Katayama S1, Hammar KS2,3, Krjutškov K1,4,5, Einarsdottir E1,5,6, Hedlin G2,3, Kere J1,5,7, Söderhäll C8,3.
1 Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
2 Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
3 Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
4 Competence Centre on Health Technologies, Tartu, Estonia.
5 Folkhälsan Institute of Genetics, and Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.
6 Current affiliation: SciLifeLab, Department of Gene Technology, KTH-Royal Institute of Technology, Solna, Sweden.
7 School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
8 Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden cilla.soderhall at ki.se.

BACKGROUND:
Airway obstruction and wheezing in preschool children with recurrent viral infections are a major clinical problem, and recognised as a risk factor for the development of chronic asthma. We aimed at analyaing whether gene expression profiling provides evidence for pathways that delineate distinct groups of children with wheeze, and in combination with clinical information could contribute to diagnosis and prognosis of disease development.

METHODS:
We analyaed leukocyte transcriptomes from preschool children (6 months-3 y) at acute wheeze (n=107), and at a revisit 2-3 months later, comparing them to age-matched healthy controls (n=66). RNA-sequencing applying GlobinLock was used. The cases were clinically followed until age 7 years. Differential expression tests, weighted correlation network analysis (WGCNA) and logistic regression were applied and correlations to 76 clinical traits evaluated.

FINDINGS:
Significant enrichment of genes involved in the innate immune responses were observed in children with wheeze. We identified a unique acute wheeze-specific gene-module, that was associated with Vitamin D levels (p<0.005) in infancy, and asthma medication and FEV1%/FVC several years later, at age 7 (p<0.005). A model that predicts LTRA-medication at 7 years of age with high accuracy was developed (AUC=0.815, 95% CI: 0.668-0.962).

INTERPRETATION:
Gene expression profiles in blood from preschool wheezers predict asthma symptoms at school-age, and therefore serve as biomarkers. The acute wheeze-specific gene module suggests that molecular phenotyping in combination with clinical information already at an early episode of wheeze may help to distinguish children that will outgrow their wheeze from those that will develop chronic asthma.


15+ VitaminDWiki pages have WHEEZING in the title

This list is automatically updated

Items found: 15
Title Modified
Vitamin D levels are low during Recurrent Wheezing - Feb 2024 24 Feb, 2024
Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023 21 Dec, 2023
Recurrent Wheezing in children is associated with low Vitamin D – several studies 04 Sep, 2022
Wheezing and asthmatic children have weaker Vitamin D responses - May 2022 19 May, 2022
Vitamin D reduces RTI, Omega-3 reduces wheezing or asthma – March 2022 11 Apr, 2022
Viral infection wheezing 24X more likely if less than 15 ng of Vitamin D – Dec 2019 04 Apr, 2020
Gene which predicts wheezing is associated with low vitamin D – Oct 2019 18 Oct, 2019
Black infant recurrent wheezing rate dropped from 42 percent to 31 percent with just 400 IU of vitamin D – RCT Dec 2018 06 Dec, 2018
Recurrent wheeze 2X more likely if endotoxin (on some bacteria) and low vitamin D – May 2016 15 Dec, 2017
Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015 10 May, 2016
2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015 09 Sep, 2015
Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis Aug 2015 25 Aug, 2015
Children who wheezed were 2.7X more likely to have little vitamin D – April 2014 18 Apr, 2015
Vitamin D and wheeze – especially in seniors – Aug 2011 26 Apr, 2014
Single dose of 200,000 IU of vitamin D during pregnancy did not reduce wheezing 3 years later – June 2013 30 Jun, 2013

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