Nonskeletal and skeletal effects of high doses versus low doses of vitamin D3 in renal transplant recipients: Results of the VITALE (VITamin D supplementation in renAL transplant recipients) study, a randomized clinical trial
Am J Transplant . 2023 Jan 9;S1600-6135(22)29286-7. doi: 10.1016/j.ajt.2022.12.007
Marie Courbebaisse 1, Aurelie Bourmaud 2, Jean-Claude Souberbielle 3, Rebecca Sberro-Soussan 4, Valérie Moal 5, Yannick Le Meur 6, Nassim Kamar 7, Laetitia Albano 8, Antoine Thierry 9, Jacques Dantal 10, Clément Danthu 11, Karine Moreau 12, Emmanuel Morelon 13, Anne-Elisabeth Heng 14, Dominique Bertrand 15, Nadia Arzouk 16, Peggy Perrin 17, Marie-Pascale Morin 18, Philippe Rieu 19, Claire Presne 20, Philippe Grimbert 21, Didier Ducloux 22, Matthias Büchler 23, Moglie Le Quintrec 24, Nacéra Ouali 25, Vincent Pernin 26, Nicolas Bouvier 27, Antoine Durrbach 28, Eric Alamartine 29, Christine Randoux 30, Virginie Besson 31, Marc Hazzan 32, Justine Pages 33, Sandra Colas 34, Marie-Liesse Piketty 3, Gérard Friedlander 35, Dominique Prié 36, Corinne Alberti 2, Eric Thervet 37
Vitamin D sufficiency is associated with a reduced risk of fractures, diabetes mellitus, cardiovascular events, and cancers, which are frequent complications after renal transplantation. The VITALE (VITamin D supplementation in renAL transplant recipients) study is a multicenter double-blind randomized trial, including nondiabetic adult renal transplant recipients with serum 25-hydroxy vitamin D (25(OH) vitamin D) levels of <30 ng/mL, which is randomized 12 to 48 months after transplantation to receive
- high (100 000 IU) or
- low doses (12 000 IU)
of cholecalciferol every 2 weeks for 2 months and then monthly for 22 months.
The primary outcome was a composite endpoint, including diabetes mellitus, major cardiovascular events, cancer, and death. Of 536 inclusions (50.8 [13.7] years, 335 men), 269 and 267 inclusions were in the high-dose and low-dose groups, respectively. The serum 25(OH) vitamin D levels increased by 23 versus 6 ng/mL in the high-dose and low-dose groups, respectively (P < .0001). In the intent-to-treat analysis, 15% versus 16% of the patients in the high-dose and low-dose groups, respectively, experienced a first event of the composite endpoint (hazard ratio, 0.94 [0.60-1.48]; P = .78), whereas
1% and 4% of patients in the high-dose and low-dose groups, respectively, experienced an incident symptomatic fracture (odds ratio, 0.24 [0.07-0.86], P = .03).
The incidence of adverse events was similar between the groups. After renal transplantation, high doses of cholecalciferol are safe but do not reduce extraskeletal complications (trial registration: ClinicalTrials.gov; identifier: NCT01431430).
32+ VitaminDWiki pages have TRANSPLANT in title
Items found: 33
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Fecal transplants - many studies |
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26 Apr, 2023 |
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Fracture 4X less likely following kidney transplant if high-dose Vitamin D (100,000 every 2 weeks) – RCT Jan 2023 |
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25 Jan, 2023 |
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Fecal transplant from young reduced age-associated defects in old (mice so far) – Aug 2021 |
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27 Aug, 2021 |
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Liver transplants in children more likely to be rejected if insufficient vitamin D – Aug 2021 |
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07 Aug, 2021 |
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Very low Vitamin D levels after Liver transplant in children (need Calcitriol or topical) – May 2021 |
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03 Jun, 2021 |
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Kidney transplant rejection 1.8X more likely if low vitamin D – May 2021 |
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22 May, 2021 |
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1,000 IU of vitamin D provides little benefit (Kidney transplant in this case) – April 2021 |
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22 Apr, 2021 |
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Vitamin D helps organ transplant |
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24 Mar, 2021 |
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Organ Transplant patients probably need more UV and or vitamin D April 2010 |
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24 Mar, 2021 |
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If you are getting a lung transplant you must have vitamin D - April 2012 |
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24 Mar, 2021 |
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Omega-3 reduced pancreas transplant failure by 3X and sepsis by 2X – review Dec 2019 |
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18 Dec, 2019 |
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Stem cell transplant (HSCT) patients are dying due to lack of vitamin D – Oct 2019 |
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28 Oct, 2019 |
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Stem Cell Transplants consume vitamin D – July 2011 |
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23 Oct, 2019 |
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Stem cell transplant (HSCT). death 28 percent less likely for each 10ng higher vitamin D level – Oct 2019 |
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23 Oct, 2019 |
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Fecal transplants could prevent 12,000 C.difficile deaths a year, but one person died, so lets wait – July 2019 |
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01 Aug, 2019 |
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4X reduction in bone fractures following Kidney Transplant with monthly Vitamin D (100,000 IU) - RCT June 2019 |
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17 Jun, 2019 |
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Fecal transplants increased Vitamin D levels (germ-free mice) – March 2018 |
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29 Jun, 2018 |
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Liver transplant needs Vitamin D (actually semi-activated, not regular) – May 2017 |
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27 May, 2017 |
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Bone marrow transplant – like other traumas – lowers vitamin D levels – July 2011 |
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17 Apr, 2017 |
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Vitamin D may help after organ transplant – if can give enough – Jan 2011 |
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25 Mar, 2017 |
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4X fewer malignancies after kidney transplant if got active vitamin D – Prospective Score Sept 2012 |
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25 Mar, 2017 |
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Kidney transplant patients advised to avoid the sun, then 90% have very low vitamin D levels – Sept 2012 |
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25 Mar, 2017 |
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Vitamin D and biophospates are needed after organ transplant – Aug 2011 |
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25 Mar, 2017 |
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Calcitriol (active Vitamin D) recommended after kidney transplant – March 2014 |
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28 Apr, 2016 |
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Active form of vitamin D (calcitriol) cut in half the fractures following organ transplant – meta-analysis Aug 2011 |
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26 Jul, 2015 |
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Gut, Alzheimer, autism, disease, fecal transplant, etc - Dr. Perlmutter, May 2015 |
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18 May, 2015 |
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400,000 IU barely raised liver transplant candidate vitamin D levels (no surprise) – March 2015 |
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26 Mar, 2015 |
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Even with vitamin D supplementation Kidney transplant patients were deficient – Jan 2011 |
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28 Aug, 2012 |
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Babies Receive Heart Transplants Instead of Vitamin D Treatment |
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25 Jun, 2012 |
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Kidney transplant worked better if initially have high level of vitamin D – April 2012 |
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28 Apr, 2012 |
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Vitamin D levels low both before and after organ transplant July 2011 |
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27 Apr, 2012 |
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Heart transplant 19 ng vitamin D vs liver transplant 13 ng – April 2009 |
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12 Nov, 2011 |
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Many Organ transplants cause skin cancer – what is the role of UV – Feb 2012 |
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