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Fertility and sperm

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Books and Videos 265   Diseases that may be related via low vitamin D
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140 items in Fertility or Sperm in VitaminDWiki

See also:
Overview Women and Vitamin D
Overview Pregnancy and vitamin D    Fertility and Vitamin D – several articles
Endometriosis
Ensure a healthy pregnancy and baby - take Vitamin D before conception
IVF OR "IN VITRO FERTILIZATION" etc. in 18 VitaminDWiki titles


Vitamin D greatly improves Fertility

Increased male Vitamin D increases fertility

Decreased Fertility if decreased Vitamin D Receptor


18+ VitaminDWiki pages have IVF or IN VITRO FERTILIZATION etc. in the title

This list is automatcially updated

Items found: 20
Title Modified
3X more pregnancies when Vitamin D levels are high (assisted reproduction, women only) – Oct 2021 08 Jul, 2024
In vitro Fertilization not helped if Vitamin D is slightly above 30 ng (need 50 ng) – July 2024 05 Jul, 2024
In vitro fertilization and Vitamin D – many studies 19 Apr, 2024
Vitamin D associated with 60 percent better assisted reproduction success – Dec 2019 17 Feb, 2024
In vitro fertilization is more successful when vitamin D in ovaries, not just blood, is increased – April 2022 27 Apr, 2022
Vitamin D levels in cells, not blood, is important (IVF follicular fluid in this case) – Aug 2021 27 Apr, 2022
In vitro fertilization NOT helped by 600,000 IU of vitamin D – RCT Sept 2021 30 Jan, 2022
IVF 4X more successful for white women with lots of vitamin D – many studies 17 Dec, 2021
In Vitro Fertilization clinical trial using 50,000 IU of Vitamin D bi-weekly – Dec 2024 14 Sep, 2020
Live birth 1.7 X more likely after IVF if good level of vitamin D – meta-analysis Aug 2020 15 Aug, 2020
In-vitro Fertilization costs at least 10,000 dollars, Vitamin D costs 5 dollars 02 Oct, 2019
Poor ovarian response (poor IVF) associated with low vitamin D – Sept 2019 28 Sep, 2019
IVF 60 percent more successful if woman had sufficient vitamin D – Dec 2017 29 Dec, 2017
IVF 50 percent more likely to result in pregnancy if high vitamin D – meta-analysis Nov 2017 20 Nov, 2017
Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review March 2015 14 May, 2017
In vitro fertilization not helped by vitamin D if ignore high levels and male levels – meta Mar 2016 14 Jan, 2017
Assisted Reproduction might be aided by Vitamin D – review Dec 2014 23 May, 2015
In Vitro Fertilization (D5 SET ICSI) 40 percent more successful if high vitamin D – Sept 2014 15 Aug, 2014
Clinical Trial vitamin D levels and IVF success – May 2011 13 Aug, 2014
Vitamin D somewhat assists reproduction – both the mother and the father – May 2014 10 Jun, 2014

7 Items in both of the categories Intervention AND Fertility/Sperm


140 Fertility items


Infertility is decreased by Vitamin D supplementation – meta-analysis Feb 2023

__Influence of Vitamin D supplementation on reproductive outcomes of infertile patients: a systematic review and meta-analysis++
Reprod Biol Endocrinol. 2023; 21: 17doi: 10.1186/s12958-023-01068-8
Xiangqian Meng,1 Jiayao Zhang,2 Qi Wan,1 Jihua Huang,3 Tingting Han,3 Ting Qu,corresponding author#3 and Lin-lin Yucorresponding author#4

Background
Low vitamin D status has been associated with an increased risk for infertility. Recent evidence regarding the efficacy of vitamin D supplementation in improving reproductive outcomes is inconsistent. Therefore, this systematic review was conducted to investigate whether vitamin D supplementation could improve the reproductive outcomes of infertile patients and evaluate how the parameters of vitamin D supplementation affected the clinical pregnancy rate.

Methods
We searched seven electronic databases (CNKI, Cqvip, Wanfang, PubMed, Medline, Embase, and Cochrane Library) up to March 2022. Randomized and cohort studies were collected to assess the reproductive outcomes difference between the intervention (vitamin D) vs. the control (placebo or none). Mantel-Haenszel random effects models were used. Effects were reported as odds ratio (OR) and their 95% confidence interval (CI). PROSPERO database registration number: CRD42022304018.

Results
Twelve eligible studies (n = 2352) were included: 9 randomized controlled trials (RCTs, n = 1677) and 3 cohort studies (n = 675). Pooled results indicated that infertile women treated with vitamin D had a significantly increased clinical pregnancy rate compared with the control group (OR: 1.70, 95% CI: 1.24–2.34; I2 = 63%, P = 0.001). However, the implantation, biochemical pregnancy, miscarriage, and multiple pregnancy rates had no significant difference (OR: 1.86, 95% CI: 1.00–3.47; I2 = 85%, P = 0.05; OR: 1.49; 0.98–2.26; I2 = 63%, P = 0.06; OR: 0.98, 95% CI: 0.63–1.53; I2 = 0%, P = 0.94 and OR: 3.64, 95% CI: 0.58–11.98; I2 = 68%, P = 0.21). The improvement of clinical pregnancy rate in the intervention group was influenced by the vitamin D level of patients, drug type, the total vitamin D dosage, the duration, administration frequency, and daily dosage of vitamin D supplementation. The infertile women (vitamin D level < 30 ng/mL) treated with the multicomponent drugs including vitamin D (10,000–50,000 IU or 50,000–500,000 IU), or got vitamin D 1000–10,000 IU daily, lasting for 30–60 days could achieve better pregnancy outcome.

Conclusion
To the best of our knowledge, this is the first meta-analysis systematically investigated that moderate daily dosing of vitamin D supplementation could improve the clinical pregnancy rate of infertile women and reported the effects of vitamin D supplementation parameters on pregnancy outcomes. A larger sample size and high-quality RCTs are necessary to optimize the parameters of vitamin D supplementation to help more infertile patients benefit from this therapy.
 Download the PDF from VitaminDWiki


Improved male fertility if increased Vitamin D and/or Calcium - Dec 2023

Calcium and vitamin D homoeostasis in male fertility
Proceedings of the Nutrition Society, Page 1 of 14 doi:10.1017/S002966512300486X
Sam Kafai Yahyavi1,2, Ida Marie Boisen1,2, Zhihui Cui1,2, Mads Joon Jorsal1,2, Ireen Kooij1,2,
Rune Holt1,2, Anders Juul3,4,5 and Martin Blomberg Jensen1,2

Calcium and vitamin D have well-established roles in maintaining calcium balance and bone health. Decades of research in human subjects and animals have revealed that calcium and vitamin D also have effects on many other organs including male reproductive organs. The presence of calcium-sensing receptor, vitamin D receptor, vitamin D activating and inacti­vating enzymes and calcium channels in the testes, male reproductive tract and human spermatozoa suggests that vitamin D and calcium may modify male reproductive function. Functional animal models have shown that vitamin D deficiency in male rodents leads to a decrease in successful mating and fewer pregnancies, often caused by impaired sperm motil­ity and poor sperm morphology. Human studies have to a lesser extent validated these findings; however, newer studies suggest a positive effect of vitamin D supplementation on semen quality in cases with vitamin D deficiency, which highlights the need for initiatives to prevent vitamin D deficiency. Calcium channels in male reproductive organs and sperm­atozoa contribute to the regulation of sperm motility and capacitation, both essential for successful fertilisation, which supports a need to avoid calcium deficiency. Studies have demonstrated that vitamin D, as a regulator of calcium homoeostasis, influences calcium influx in the testis and spermatozoa. Emerging evidence suggests a potential link between vitamin D deficiency and male infertility, although further investigation is needed to estab­lish a definitive causal relationship. Understanding the interplay between vitamin D, calcium and male reproductive health may open new avenues for improving fertility outcomes in men.
 Download the PDF from VitaminDWiki


Vitamin D is significantly associated with male fertility and sperm quality - meta-analyses 2019 and 2023

The association between serum vitamin D, fertility and semen quality: A systematic review and meta-analysis - Nov 2019
International Journal of Surgery Vol 71, Nov 2019, Pages 101-109https://doi.org/10.1016/j.ijsu.2019.09.025 FREE PDF
The Association between Serum Vitamin D Levels and Male Fertility: A Systematic Review and Meta-Analysis - Aug 2023
Andrologia Vol 2023 | Article ID 9002938 | https://doi.org/10.1155/2023/9002938 FREE PDF


600,000 IU of vitamin D a few weeks for women before IVF did not help - RCT April 2021

Single oral dose of vitamin D3 supplementation prior to in vitro fertilization and embryo transfer in normal weight women: the SUNDRO randomized controlled trial
American Journal of Obstetrics and Gynecology, https://doi.org/10.1016/j.ajog.2021.04.234

Background: Improving in vitro fertilization (IVF) success is an unmet need. Observational studies suggested that women with deficient or insufficient vitamin D have lower chances of success, but whether supplementation improves clinical pregnancy rate is unclear.

Objective: To determine whether oral vitamin D3 supplementation may improve clinical pregnancy in women undergoing an IVF cycle

Study design: The SUNDRO trial is a two-centers randomized superiority double-blind placebo controlled trial. Subjects were recruited between October 2016 and January 2019. Participants were women aged 18-39 years with low vitamin D (peripheral 25-hydroxyvitamin D < 30 ng/ml), serum calcium ≥ 10.6 mg/dl, body-mass index (BMI) 18-25 Kg/m2, anti-mullerian hormone (AMH) levels > 0.5 ng/ml, starting their first, second, or third treatment cycle of conventional IVF or intracytoplasmic sperm injection (ICSI). The primary outcome was the cumulative clinical pregnancy rate per cycle. Pregnancies obtained with both fresh or frozen embryo transfers were included. Clinical pregnancy was defined as intrauterine gestational sac with viable fetus. The primary analysis was performed according to the intention to treat principle and could also include natural conceptions. Secondary outcomes included total dose of gonadotropins used, embryological variables (number of oocytes retrieved, number of suitable oocytes retrieved, fertilization rate and rate of top quality embryos) and clinical outcomes (miscarriage rate and live birth rate).

Results
630 women were randomized 2-12 weeks prior to initiate the IVF cycle to receive either a single dose of 600,000 IU of vitamin D3 (n=308) or placebo (n=322). One hundred thirteen (37%) and 130 (40%) women achieved a clinical pregnancy in the treatment and placebo groups, respectively (p=0.37). The risk ratio (RR) of clinical pregnancy in women receiving vitamin D3 was 0.91 (95% confidence interval-CI: 0.75 – 1.11). Compared to placebo, vitamin D3 supplementation did not significantly improve the secondary outcomes. Exploratory subgroup analyses for BMI, age, indication to IVF, ovarian reserve, interval between drug administration and initiation of the cycle and basal levels of 25-hydroxyvitamin D failed to highlight any clinical situation that could benefit from the supplementation.

Conclusions: In normal weight women with preserved ovarian reserve and low vitamin D levels undergoing IVF cycles, a single oral dose of 600,000 IU of vitamin D3 does not improve the chances of clinical pregnancy. Although the findings do not support the use of vitamin D3 supplementation to ameliorate IVF success, further studies are required to rule out milder but potentially still interesting benefits as well as exploring the effectiveness of alternative modalities of supplementation.


Clinical trial of 50,000 IU vitamin D weekly to improve IVF success - Phase 4 trial announced July 2017

Vitamin D Supplementation in Vitamin Deficient Women Undergoing IVF Cycles: Does it Affect the Fertility Outcome?
Unfortunately trial is only giving vitamin D to the women, and for only 2 months
They will be measuring results over the next 12 months
Doubt that this clinical trial will be successful
50,000 IU bi-weekly to both man and woman during an entire year would have had far better success.


59% reduction in sperm count around the world in just 40 years - Mercola Aug 2017. May 2022

Skyrocketing Male Infertility May Threaten Mankind’s Survival - Mercola


Eating more fish (probably Omega-3 and Vitamin D) resulted in a 16% increase in babies - May 2018

Survey of 501 couples, New York Times
Reportingo n study in Journal of Clinical Endocrinology and Metabolism https://doi.org/10.1210/jc.2018-00385

  • "By 12 months, 92 percent of couples who ate fish twice a week or more were pregnant, compared with 79 percent among those who ate less."

Men Are Freaking Out About Their Sperm NYT July 2018

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Vitamin D: Study Finds Impaired Fertility - May 2016

[http://www.medpagetoday.com/obgyn/pregnancy/58076|URl]
RCT of Vitamin D and Fertility - daily for a year - to 16 weeks after birth
This data disagrees with a majority of studies on this page

Became pregnantComplications
Placebo 38%52%
1400 IU33%23% for 1400 and 2800 IU
2800 IU39%

Statistical certainty of the percentages was not given in the abstract

  • "Complications during labor, including preeclampsia and postpartum bleeding, were significantly more frequent in the placebo group compared with the combined treatment groups (52% versus 23%, P=0.005)."
  • "The study found no difference in other complications including pre-term birth, miscarriage, gestational diabetes, and infections"
  • No comment on any differences in Still Births, Death during first year, etc.
  • Wonder if mothers getting lots of vitamin D had more alive and healthy children at the one year mark compared to placebo

Abstract


Why Are Young People Having So Little Sex? Nov 2018

The Atlantic Vitamin D is not mentioned

  • "...Americans are in the midst of a sex recession"
  • "...crushing economic pressures, of surging anxiety rates, of psychological frailty, of widespread antidepressant use, of streaming television, of environmental estrogens leaked by plastics, of dropping testosterone levels, of digital porn, of the vibrator’s golden age, of dating apps, of option paralysis, of helicopter parents, of careerism, of smartphones, of the news cycle, of information overload generally, of sleep deprivation, of obesity. Name a modern blight, and someone, somewhere, is ready to blame it for messing with the modern libido?

The Disappearing Y Chromosome Atlantic Mag Dec 2019

It’s surprisingly common for men to start losing entire chromosomes from blood cells as they age

  • "Now a new study—the largest yet of this phenomenon—estimates that 20 percent of 205,011 men in a large genetic database called the UK Biobank have lost Y chromosomes from some detectable proportion of their blood. By age 70, 43.6 percent of men had the same issue."1

No mention of Vitamin D

5X longer to induce pregnancy if male is >45

The male biological clock – How to tell the time MDEdge Oct 2021


Vitamin D in human reproduction: some answers and many more questions - Jan 2021

 Download the PDF from VitaminDWiki


Less fertile mice if low Vitamin D (fully-activated Vitamin D) - Feb 2021

  • 1,25-Dihydroxyvitamin D deficiency accelerates male reproductive senescence in aging mice
    • doi: 10.1152/ajpendo.00531.2020, free abstract, study is behind $25 paywall

Email from a woman who read this page, tested and then took vitamin D - Dec 15. 2022

Hello
I want to thank you for providing the information on your website. I was able to give birth to a healthy baby after 4 miscarriages.
I read many of the articles and saw the testimony a man had wrote about his wife having a baby. I had been tested for many things but my vitamin D level wasn't checked.
I ordered a test on my own and I was at a 13. I got it up to a 94 and was pregnant the next month. Taking high dose vitamin D is the only change I made and I hope I can share this knowledge with others struggling with fertility problems.
Candice

Fertility and sperm        
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Attached files

ID Name Comment Uploaded Size Downloads
21405 D decrease infertility - meta-analysis_CompressPdf.pdf admin 06 Jul, 2024 758.33 Kb 9
20560 Calcium_and_Vitamin_D_Homeostasis_in_Male_Fertilit_CompressPdf.pdf admin 30 Dec, 2023 230.45 Kb 83
17594 endocrine-disrupting-chemicals- Mercola May 2022.pdf admin 14 May, 2022 194.96 Kb 385
14941 Human fertility some answers, more questions.pdf admin 28 Jan, 2021 68.97 Kb 1417
10244 Fertile meta 3.jpg admin 25 Jul, 2018 35.77 Kb 4895
10243 Fertile meta.jpg admin 25 Jul, 2018 19.10 Kb 5708