Hypercalcemia Without Hypervitaminosis D During Cholecalciferol Supplementation in Critically Ill Patients.
Nutr Clin Pract. 2019 Oct 11. doi: 10.1002/ncp.10407.
Most groups taking high-dose vitamin D do one or more of the following:
- Increase Magnesium
- Increase Vitamin K
- Reduce Calcium intake - especially pills
- Increase Water
The founder of VitaminDWiki takes 20,000 IU Vitamin D average along with Magnesium and Vitamin K
Items in both categories Calcium and Vitamin K are listed here:
- Calcium and Vitamin K2 - many studies
- Lowering Calcium Risk when having High Dose Vitamin D3 – Cawley Dec 2019
- Excess Calcium in critically ill patients taking 10,000 IU of vitamin D (solutions - Vitamin K, or Magnesium, or water) – Oct 2019
- Calcium Supplementation is OK provided you also take Vitamin K – Feb 2019
- Calcium supplements go to muscle, not bone, unless have enough Vitamin K – Feb 2019
- Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
- Vitamin D Cofactors in a nutshell
- Vascular calcification greatly reduced by 3 per week 1000 ug of Vitamin K2 MK-7 – Dec 2013
- Increased Vitamin K2 reduces the problems of excess Calcium – Nov 2013
- Review of Micronutrients such as vitamin D for women and childhood – Aug 2013
- Healthy bones need Ca, Silicon, Vitamins B, C, D, and K – Dec 2012
- Interview of Vitamin K2 and Calcium Paradox author by Dr. Mercola – Dec 2012
- Vitamin K2 and the Calcium Paradox – 2012 book
- Low cost cofactors for vitamin D
- Postmenopausal women should supplement vitamins C D K and Calcium – June 2010
Items in both categories Calcium and Magnesium are listed here:
- You are probably unaware that health needs a Ca-Mg ratio of 2 – Sept 2022
- Calcium to Magnesium Ratio - many studies
- COVID treatment patent applied for - using Rutin, Vitamin D, Vitamin C, Magnesium, etc. – April 2022
- Increased dental decay if take Calcium without Magnesium – Feb 2020
- Off topic: Transcutaneous enhancers (DMSO, etc) for Vitamin D, Vitamin C, Resveratrol, Magnesium, etc.
- Colorectal Cancer risk increases 1.6 X if high Calcium, low Magnesium and a poor gene – Sept 2007
- Mineral adsorption and Vitamin D (Magnesium, Calcium, etc) - 2011
- Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
- Natural variation in mineral content of a food is typically 3 to 1 – Nov 2016
- Interactions between Magnesium, Vitamin D, and Calcium – April 2016
- Is a health problem associated with Low vitamin D, Low Magnesium, or too much Calcium – Jan 2016
- Vitamin D - Comparing Symptoms of Hypercalcemia with Low Magnesium - Sept 2015
- Vitamin D Cofactors in a nutshell
- Vitamin D increases mineral availability which protect against toxic elements - July 2015
- Stronger bones after 3 generations of tap water (more Ca and Mg) vs bottled water – March 2015
- Magnesium may be more important to kids’ bone health than calcium – May 2013
- Calcium 2X of Magnesium seems good – China Feb 2013
- RDA upper limit etc for Vitamin D and Magnesium - Sept 2011
- Weight loss and Vitamin D, Calcium, and Magnesium
- Decrease Calcium and Increase Magnesium when increasing vitamin D
- 400 IU of vitamin D Magnesium and Calcium helped Twin bones – Feb 2011
- Low cost cofactors for vitamin D
- Constipation - Magnesium, Calcium and cofactors
- Calcium in food increased much more than Magnesium in recent decades April 2010
- Search VitaminDWiki for HYPERCALCEMIA 1480 results as of Oct 2019
- Increased Calcium decreases Vitamin D in males – Nov 2020
- Hypercalcemia can result from excess Vitamin D (if not reduce Ca or increase water) Oct 2016
- No correlation found between hypercalcemia and high level of vitamin D – March 2021
- Must balance co-factors when increasing vitamin D 500 Ca, 500 Mg - which has the following concept graph
- IoM again fails to look at interactions - Nov 2010
- has the graph: dangerous to have too much Calcium while having lots of vitamin D
Holmes WL1, Maish GO 3rd2, Minard G2, Croce MA2, Dickerson RN3.
1 Department of Pharmacy, Regional One Health, Memphis, Tennessee, USA.
2 Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
3 Dept of Clinical Pharmacy and Translational Science, U. of Tennessee Health Science Center, Memphis, TN, USA.
BACKGROUND:
Vitamin D deficiency during critical illness has been associated with worsened outcomes. Because most critically ill patients with severe traumatic injuries are vitamin D deficient, we investigated the efficacy and safety of cholecalciferol therapy for these patients.
METHODS:
Fifty-three patients (>17 years of age) admitted to the trauma intensive care unit who had a serum 25-hydroxy vitamin D (25-OH vit D) concentration <20 ng/mL were given 10,000 IU of cholecalciferol daily. Efficacy was defined as achievement of a 25-OH vit D of 30-79.9 ng/mL. Safety was evaluated by the presence of hypercalcemia (serum ionized calcium [iCa] >1.32 mmol/L) or hypervitaminosis D (25-OH vit D >79.9 nmol/L). Patients were monitored for 2 weeks during cholecalciferol therapy.
RESULTS:
Twenty-four patients (45%) achieved target 25-OH vit D. No patients experienced hypervitaminosis D. Hypercalcemia occurred in 40% (n = 21) of patients; 2 patients experienced an iCa >1.49 nmol/L. 25-OH vit D was significantly greater for those who developed hypercalcemia (37.2 + 11.2 vs 28.4 + 5.6 ng/mL, respectively, P < 0.001) by the second week of cholecalciferol. Of 24 patients who achieved target 25-OH vit D, 14 (58%) experienced hypercalcemia in contrast to 24% of patients (7 out of 29) who did not achieve target 25-OH vit D (P = 0.024).
CONCLUSIONS:
Cholecalciferol normalized serum 25-OH vit D concentrations in less than half of patients yet was associated with a substantial proportion of patients with hypercalcemia without hypervitaminosis D.