Late Pregnancy Vitamin D Deficiency is Associated with Doubled Odds of Birth Asphyxia and Emergency Caesarean Section: A Prospective Cohort Study
Maternal and Child Health Journal (2020)
Hanna Augustin, Sinead Mulcahy, Inez Schoenmakers, Maria Bullarbo, Anna Glantz, Anna Winkvist & Linnea Bärebring
C-section 4X more likely when vitamin D less than 15 ng – many items
Pregnancy category starts with
- see also
- Overview Pregnancy and vitamin D
- Number of articles in both categories of Pregnancy and:Dark Skin
27 ; Depression 21 ; Diabetes 42 ; Obesity 15 ; Hypertension 43 ; Breathing 33 ; Omega-3 39 ; Vitamin D Receptor 23 Click here for details
- All items in category Infant/Child
- Pregnancy needs at least 40 ng of vitamin D, achieved by at least 4,000 IU – Hollis Aug 2017
- 34 papers with Breastfeeding of Breastfed in title as of Jan 2022
- Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick Aug 2019
- 53+ preeclampsia studies
- 94+ studies with PRETERM in the title
- "polycystic ovary syndrome" OR PCOS 303 items as of Jan 2018
- 94+ Gestational Diabetes
- c-section OR "caesarean section" (various spellings) 937 items in text as of Aug 2020
- postpartum depression 208 items as of Aug 2018
- 31 VitaminDWiki pages had MISCARRIAGE in title as of Aug 2022
- Search VitaminDWiki for "Assisted reproduction" 33 items as of Aug 2022
- Fertility and Sperm category listing has
129 items along with related searches
- (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
- Less labor pain if higher level of vitamin D – August 2021
- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
Healthy pregnancies need lots of vitamin D has the following summaryProblem
Reduces Evidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limits
RCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT
RCT = Randomized Controlled Trial
Download the PDF from VitaminDWiki
The aim of this prospective cohort study was to investigate the associations between maternal vitamin D status in late pregnancy and emergency caesarean section (EMCS) and birth asphyxia, in a population based sample of women in Sweden.
Pregnant women were recruited at the antenatal care in Sweden and 1832 women were included after exclusion of miscarriages, terminated pregnancies and missing data on vitamin D status. Mode of delivery was retrieved from medical records. EMCS was defined as caesarean section after onset of labour. Birth asphyxia was defined as either 5 min Apgar score < 7 or arterial umbilical cord pH < 7.1. Serum was sampled in the third trimester of pregnancy (T3) and 25-hydroxyvitamin D (25OHD) was analysed by liquid chromatography tandem mass spectrometry. Vitamin D deficiency was defined as 25OHD < 30 nmol/L, and associations were studied using logistic regression analysis and expressed as adjusted odds ratios (AOR).
In total, 141 (7.7%) women had an EMCS and 58 (3.2%) children were born with birth asphyxia. Vitamin D deficiency was only associated with higher odds of EMCS in women without epidural anaesthesia (AOR = 2.01, p = 0.044). Vitamin D deficiency was also associated with higher odds of birth asphyxia (AOR = 2.22, p = 0.044).
Conclusions for Practice
In this Swedish prospective population-based cohort study, vitamin D deficiency in late pregnancy was associated with doubled odds of birth asphyxia and with EMCS in deliveries not aided by epidural anaesthesia. Prevention of vitamin D deficiency among pregnant women may reduce the incidence of EMCS and birth asphyxia. The mechanism behind the findings require further investigation.
What is already known on this subject?
Poor maternal vitamin D status is suggested as a risk factor of delivery by caesarean section and birth asphyxia. However, studies are few and the data are contradictory.
What this study adds
In this population-based cohort study, maternal vitamin D deficiency doubled the odds of delivering a baby with birth asphyxia and of delivery by emergency caesarean section in women without epidural anaesthesia. The interaction between vitamin D deficiency and epidural anaesthesia might explain disparate results in previous studies, and should be considered in future studies.Emergency Caesarean 2X more likely if less than 12 ng of Vitamin D – Aug 2020
2028 visitors, last modified 28 Aug, 2020,This page is in the following categories (# of items in each category)
- All items in category Infant/Child