Ear

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17 Ear articles

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4 Ear and Infant-Child articles

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Tinnitus

Tinnitus greated decreased by weekly 50,000 IU of Vitamin D for 3 months - Jan 2021

Vitamin D Level and its Relation to Tinnitus
Egyptian Journal of Ear, Nose, Throat and Allied Sciences Article 21, Volume 22, Issue 22, January 2021, Page 1-5 (613.74 K) DOI: 10.21608/ejentas.2020.37810.1243
Salwa Mourad Abdelmawgoud, Audiovestibular Unit, Otolaryngology Department, Sohag University Egypt

1 = lowest tinnitus level

Objective: to evaluate vitamin D levels in patients with tinnitus and to assess subjectively the efficacy of its supplementation in case of deficiency.

Methodology: 35 adult complaint of bilateral tinnitus with the age range from 20 to 50 years were included. All had bilateral normal audiological evaluation. Vitamin D level was assessed and those that had deficiency received supplementation for 3 months. Tinnitus handicap inventory (THI) was taken for the first time to all participants and another time for those received vitamin D supplementation after the 3 months regiment, and comparing the results.
Result: From the 35 participants there was 30 subjects had vitamin D deficiency (85.71 %). THI before treatment showed larger numbers in scale 3 then 2, 1, 4 with no patients with scale 5.while THI after treatment showed larger numbers in scale 1 then 2 & 3 with no patients with scale 4 & 5. There was no significant correlation between THI score & Vitamin D level and the age of the participant or the duration of the complaint.

Conclusion & recommendations: vitamin D deficiency is common among tinnitus patients. The result of vitamin D supplementation is promising in cases of idiopathic tinnitus. We recommend doing vitamin D assay in patients with idiopathic tinnitus and hence giving vitamin D supplementation in case of deficiency trying to improve the quality of life.
 Download the PDF from VitaminDWiki

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Vitamin D treats Tinnitus - meta-analysis March 2023

Serum Vitamin D Concentration Is Lower in Patients with Tinnitus: A Meta-Analysis of Observational Studies
Diagnostics 2023, 13(6), 1037; https://doi.org/10.3390/diagnostics13061037
by Riccardo Nocini 1,Brandon M. Henry 2,Camilla Mattiuzzi 3ORCID andGiuseppe Lippi 4,*ORCID
1Unit of Otorhinolaryngology, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Piazzale L. A. Scuro, 37134 Verona, Italy
2 Clinical Laboratory, Division of Nephrology and Hypertension, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229, USA
3 Medical Direction, Rovereto Hospital, Provincial Agency for Social and Sanitary Services (APSS) of Trento, Via Alcide Degasperi, 38123 Trento, Italy
4 Section of Clinical Biochemistry, School of Medicine, University of Verona, Piazzale L. A. Scuro, 37134 Verona, Italy

Background: Tinnitus is a highly prevalent and frequently disabling condition, such that the identification of possible causal mechanisms would yield significant clinical and social benefits. Since vitamin D (Vit D) is involved in the pathogenesis of several ear disturbances, we review here the current scientific literature addressing the relationship between Vit D status and tinnitus.

Methods: An electronic search was conducted in PubMed, Scopus and Web of Science with the keywords “tinnitus” and “Vitamin D” or “Vit D” or “25OH-D” or “cholecalciferol” or “ergocalciferol” or “hydroxycholecalciferol”, without date (i.e., up to 8 February 2023) or language restrictions, in accordance with a protocol based on the transparent reporting of systematic reviews and meta-analysis (PRISMA) 2020 checklist, for identifying studies which assayed serum Vit D concentration in patients with or without tinnitus.

Results: Three observational, case-control studies encompassing four cohorts and totaling 468 patients with (n = 268) or without tinnitus (n = 200) were included in this meta-analysis.
Pooled analysis with quality effects models evidenced significantly reduced serum Vit D levels in patients with tinnitus compared to those without (weighted mean difference [WMD], −6.2 ng/mL; 95% CI, −10.3 to −2.1 ng/mL; I2, 56%). Serum Vit D was found to be 22% lower in patients with tinnitus compared to those without.

Possible ways low D could be associated with Tinnitus

Conclusions: Lower serum Vit D levels may be associated with tinnitus, thus paving the way to plan future trials aimed at exploring whether Vit D supplementation may aid in preventing and/or improving tinnitus.
 Download the PDF from VitaminDWiki

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Tinnitus strongly associated with low vitamin D, all tinnitus patients should be tested – Aug 2021

The role of vitamin D in subjective tinnitus-A case-control study
PLoS One. 2021 Aug 18;16(8):e0255482. doi: 10.1371/journal.pone.0255482
Magdalena Nowaczewska 1, Stanisław Osiński 1, Maria Marzec 1, Michał Wiciński 2, Katarzyna Bilicka 1, Wojciech Kaźmierczak 3

Regarding the high prevalence of vitamin D (25(OH)D) deficiency in the population and its possible association with ear diseases, we aimed to investigate the 25(OH)D serum level in patients with subjective, nonpulsating tinnitus and its effect on tinnitus severity. The study included 201 tinnitus patients and 99 controls. Patient clinical information, including tinnitus characteristics and severity according to Tinnitus Handicap Inventory (THI), loudness assessed by Visual Analogue Scale (VAS), audiometry, and the blood level of vitamin D, was recorded. The level of 25(OH)D in tinnitus patients was significantly decreased compared with the controls (19.86 ± 7.53 and 27.43 ± 8.85 ng/ml, respectively; P value < 0.0001).
More patients in the tinnitus group were deficient in vitamin D, compared with the controls (50.7% vs. 22.2% respectively, p < 0.0001). Tinnitus patients with a lower serum level of 25(OH)D (≤15 ng/dl) were significantly younger, had a higher degree of tinnitus severity measured with THI and VAS scales, had higher triglyceride and TSH levels, and a lower HDL level compared with individuals who had higher 25(OH)D level (>15 ng/dl). There was a strong correlation between the 25(OH)D level and THI. Our findings suggest that a large proportion of tinnitus patients suffers from vitamin D deficiency and that the vitamin D level correlates with tinnitus impact.
We recommend a vitamin D assessment for all tinnitus patients.
 Download the PDF from VitaminDWiki

One of the 4 articles which cited the above study as of April 2023

• Serum Vitamin D Concentration Is Lower in Patients with Tinnitus: A Meta-Analysis of Observational Studies - March 2023 FREE PDF
  • "Serum Vit D was found to be 22% lower in patients with tinnitus compared to those without. "

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Very loud tinnitus might result in memory loss and dementia - 3 studies

• Beyond Hearing Loss: Does Tinnitus Cause Cognitive Impairment? - Feb 2020 FREE PDF
• Risk of early-onset dementia among persons with tinnitus: a retrospective case–control study - June 2021 FREE PDF
• The impact of tinnitus on working memory capacity - Oct 2020 FREE PDF