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Different amounts of vitamin D needed to prevent different diseases – Dec 2013

Does Vitamin D Sufficiency Equate to a Single Serum 25-Hydroxyvitamin D Level or Are Different Levels Required for Non-Skeletal Diseases?

Nutrients 2013, 5(12), 5127-5139; doi:10.3390/nu5125127 (doi registration under processing)
Simon Spedding 1,spedding@adam.com.au, Simon Vanlint 2 Howard Morris 1,3and Robert Scragg 4
1 Division of Health Sciences, University of South Australia, Adelaide, SA 5000, Australia
2 Discipline of General Practice, School of Population Health, University of Adelaide, Adelaide, SA 5005, Australia
3 SA Pathology, PO Box 14, Rundle Mall, Adelaide, SA 5000, Australia
4 School of Population Health, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
Received: 28 October 2013; in revised form: 27 November 2013 / Accepted: 28 November 2013 / Published: 16 December 2013

Objective: Clarify the concept of vitamin D sufficiency, the relationship between efficacy and vitamin D status and the role of Vitamin D supplementation in the management of non-skeletal diseases. We outline reasons for anticipating different serum vitamin D levels are required for different diseases.

Method: Review the literature for evidence of efficacy of supplementation and minimum effective 25-hydroxyvitamin D (25-OHD) levels in non-skeletal disease.

Results: Evidence of efficacy of vitamin supplementation is graded according to levels of evidence.
Minimum effective serum 25-OHD levels are lower for

  • skeletal disease, e.g., rickets (25 nmol/L), osteoporosis and fractures (50 nmol/L), than for
  • premature mortality (75 nmol/L) or non-skeletal diseases, e.g., depression (75 nmol/L), diabetes and cardiovascular disease (80 nmol/L),
  • falls and respiratory infections (95 nmol/L) and
  • cancer (100 nmol/L).

Conclusions: Evidence for the efficacy of vitamin D supplementation at serum 25-OHD levels ranging from 25 to 100 nmol/L has been obtained from trials with vitamin D interventions that change vitamin D status by increasing serum 25-OHD to a level consistent with sufficiency for that disease. This evidence supports the hypothesis that just as vitamin D metabolism is tissue dependent, so the serum levels of 25-OHD signifying deficiency or sufficiency are disease dependent.


Premature mortalityLevel 1 (Systematic Review)75 nmol 30 ng
Falls prevention Level 1 (Systematic Review)95 nmol 38 ng
Cancer preventionLevel 2 (RCT)100 nmol 40 ng
Respiratory infection prevention Level 2 (RCT)95 nmol 38 ng
Diabetes prevention Level 2 (RCT)80 nmol 32 ng
Depression treatment Level 2 (RCT)75 nmol 30 ng
Musculoskeletal pain management Level 2 (RCT)
Musculoskeletal strength Level 3-1 (Pseudo RCT)
Dental disease Level 3-2 (Study with Controls)> 84nmol > 37 ng
Cardiovascular disease Level 3-2 (Study with Controls) 80 nmol 32 ng
Health service utilisation Level 3-2 (Study with Controls)

Australian National Health and Medical Research Council Evidence Hierarchy

  • 1 Systematic review of Level II studies
  • 2 Randomised controlled trial,
  • 3-1 Pseudo-randomised controlled trial
  • 3-2 Comparative study with concurrent controls:
       non-randomised, experimental trial,cohort study, case-control study, or interrupted time series with a control group
  • 3-3A comparative study without concurrent controls:
       historical control study, or two or more single arm study, Interrupted time series without a parallel control group
  • 4 Case series with either post-test or pre-test/post-test outcomes

PDF is attached at the bottom of this page


Comment by VitaminDWiki

There is a lot of evidence that the higher the vitamin D levels, the less occurrence of a particular disease as well of fewer of all diseases.
The study on this page just shows the detectable beginnings of disease prevention due to vitamin D
A nice summary of the prevention evidence is in the following chart
There are also many studies which prove that vitamin D TREATS diseases.

See also VitaminDWiki

derived from Grassroots 2013

Proof that Vitamin D Works has the following summary

Proven: Vitamin D prevents or treats 86  health problems
VitaminDWiki   Feb 2018
Go to  http://is.gd/proofvitd   to get details

This is one of 9,000+ Vitamin D pages which can be read in any of 103 languages
Click on pink box in the upper right to select a language

Dec 2016 PDFs of this page (75 proofs) in No such attachment on this page  No such attachment on this page  No such attachment on this page  No such attachment on this page  No such attachment on this page  No such attachment on this page   No such attachment on this page  No such attachment on this page
No such attachment on this page

Health Problem
Treat
Prevent
Reduction by Vit D
   click for details
RCT = Random Controlled Trial
   * = link to additional RCT   CT = Clinical Trial
HypertensionT
P
149 to 142 mm Hg
HT risk reduced 10X
RCT*  *, 2400 IU.  100,000 IU*
When Vitamin D > 40 ng
Cardiovascular after attack T 32 % fewer deaths CT 1000 IU
Diabetes Type 1 P 85 % 12000 kids, 2000 IU
Diabetes Type 2T 62 % RCT* CRP reduction, 4000 IU
Injection is far better - RCT *,
Back Pain T 95 %
reduced 50%
5000/10000 IU
60,000 IU weekly
Influenza P 90 % RCT *, 2000 IU
Falls P 50%RCT, 100,000 IU monthly
RCT with Meals on Wheels 2016
Hip Fractures P 30 % RCT * 800 IU
Rickets P 98 % Turkey, 400 IU NOT RCT, given to all children
Raynaud's Syndrome T 40 % RCT, visual scale, 20000 IU Avg
Menstrual pain P 76 % RCT, 7000 IU Avg, PMS reduced by half
Pregnancy risks P 50 % RCT, 4000 IU
C-section, unplanned P 50 % RCT, 4000 IU, small study
Low birth weight P 60 % RCT * 1000 IU of D2
TBP 60 % RCT, 800 IU
Breast Cancer P 60 % RCT, 1100 IU (2007)
Rheumatoid Arthritis pain T 40 % RCT, 500 IU, added to prescription
Cystic Fibrosis T 75 %
2nd study improved
RCT, pilot 4X fewer deaths 250,000 IU
RCT, pilot 8,200 IU
Chronic Kidney T 90 to 70 PTH RCT, 3500 IU,
Respiratory Tract Infection P 63 % RCT, 4000 IU 1 year 2nd RCT: 2000/800 IU
3rd RCT 20,000 IU weekly
Lupus T zero flares Loading then 100,000 IU monthly, RCT too
Sickle Cell T Less pain RCT, up to 100,000 IU/week
Leg ulcer healing T 4X faster RCT, 50,0000 IU/week, small study
Traumatic Brain Injury T 2X RCT, 20,0000 IU/day with progesterone
Parkinson's DiseaseT StabilizedRCT, 1200 IU/day
Multiple SclerosisP
T
68%
95% were CURED
RCT, 7100 IU prevent pre-MS ==> MS
20,000 to 140,000 IU/day
Congestive Heart Failure T 90 % RCT, 1000 IU infants (also: Adults, not RCT)
Middle Ear Infection P 30 % RCT, 1000 IU infants
GingivitisT 88 %RCT, 2000 IU
Muscle in seniors T 17 % more muscle RCT, 4000 IU
Antibiotic use when >70y T 47 % RCT, 60,000 IU monthly
Infants tallerBenefit1 cm tall RCT, 50,000 IU weekly, 8 weeks
Gestational Diabetes T Reduced 3X RCT, 2 doses of 50,000 IU
After Heart Attack T +6% ejection fraction RCT, 800,000 IU one time
Prostate Cancer T Fewer +cores RCT, 4000 IU (2012)
Asthma P   T Reduced symptoms RCT, 60K IU/month;
RCT 50K IU/week
Need good D at 4 weeks into preg.
Depression T Reduced RCT 300,000 IU injection
RCT 1500 IU helped Prozac
Low vitamin D
while breastfed
P All infants > 20 mg RCT, 5,000 IU
Fibromyalgia T Half of many still has FibroRCT, 30-48 ng   RCT 50K IU/week
Hives, Chronic T Reduced 40% RCT, 4000 IU added
CholesterolT Reduced 4 mg RCT, 400 IU + Ca
Weight Loss T lost 5 more lbs RCT, 2000 IU +diet +exercise
Gestational DiabetesP 40% RCT * , 5,000 IU
Chronic Obstructive
Pulmonary Disease
T 17X improvement CT, 50,000 IU weekly
RCT 100,000 IU monthly
Asthma T 1/2 Asthma attacks RCT >42 mg of vitamin D
Quality of Life (QoL) T Nursing Home QoL CT, 4,000 IU in daily bread
Death of Critically Ill Patients T 20% increase in survivability RCT 540 K IU loading than 90K monthly
Restless Leg Syndrome T Score 26 ==> 10 CT, Vitamin D dose size not state in abstract
Hepatitis-C T Enhanced conventional drugs RCT 2.000 IU
Chron's disease T improved when > 30 ng
2nd study fewer relapses
RCT 2,000 IU
10,000 IU RCT
Pre-term birth P 2.5X decrease, also:
fewer c-section & better Apgar
RCT 2,000 IU India
Lupus T Pain reduced RCT 4,000 IU
Cluster headaches T CH eliminated in 60% 10,000 IU, Mg, Omega-3, etc
Autism T 80% improved CT 300 IU/kg/day for 3 months
PreDiabetes T ~20% reduced RCT 60,000 IU/month
Weight loss:
Overweight and Obese
T 12 lbs in 6 months RCT 100,000 IU/month
Sarcopenia = muscle loss T 27% increase RCT 1,000 IU
Growing Pains T 60% decrease ~100,000 IU/month -NOT RCT, given to all
2nd study, similar results
Osteoarthritis pain T 60% decrease 50,000 IU/weekly - NOT RCT, given to all
Amyotrophic Lateral Sclerosis T helped 2,000 IU - NOT RCT, given to all
Vertigo T 3X reduction if raised > 10ng 600,000 IU load, then maint.
NOT RCT, given to all
Warts T 80% eliminated injection NOT RCT, given to all
Metabolic Syndrome P reduced 44% when VitD
increased by 30 ng
NOT RCT, given to all
Hay fever P reduced 48%1,000 IU for 30 days RCT
Preeclampsia P Recurrance cut in half
3.6 X less likely if > 30 ng
50,000 IU every 2 weeks RCT
4,000 IU daily RCT
Blood cell cancer
Multiple Myeloma
T Survival 90% vs 50%10,000 IU/week
NOT RCT, given to all
Irritable Bowel Syndrome T Reduced3,000 IU spray RCT
Urinary Tract Infection P 50% reduction RCT 20,000 IU weekly
Mite Allergy P 5X reductionRCT 2,000 IU preg, 800 IU child
Perinatal depression
(depression near birth)
T 50% reduction RCT 2,000 IU for just a few weeks
Vaginosis T 10X reductionRCT 2,000 IU
Eczema T Reduced2 RCT 1,600 IU
Non-Alcoholic
Fatty Liver Disease
T Reduced RCT 20,000 IU weekly
Knee Osteoartiritis T Pain Reduced RCT 60,000 IU monthly after loading dose
Tuberculosis T Faster Recovery RCT single 450,000 IU dose
Stroke - Ischemic T Faster Recovery RCT single 600,000 IU injection
Sepsis T Reduce ICU and Hospital
length of stay by 7 days each
RCT 400,000 IU
Trauma deaths T 50% fewer deaths Vitamin D & Glutamine
NOT RCT, given to all
Hemodialysis patients T helped 50,000 IU weekly NOT RCT, given to all
Fatty liver - child T 2 X reduction Vitamin D & DHA RCT
Fatigue T Reduced 100,000 IU single dose
NOT RCT, given to all
Sleep Disorders T Nicely treated 50.000 IU bi-weekly   RCT
Pneumonia
(Ventilator-associated)
T Death rate cut in half300,000 IU injection   RCT
Infertile males T birth rate doubled 300,000 IU + maint   RCT
Waist size T Waist size reduced 3 cm 100,000 IU loading + maint for 6 months
for those with Metabolic Syndrome
NOT RCT, given to all
Attention Deficient
Hyperactivity Disorder
T Reduced 3,000 IU for 12 weeks   RCT

How often might 50000 IU vitamin D be taken - results of clinical trials re-arranges the above data (from summer 2013) by dose

Attached files

ID Name Comment Uploaded Size Downloads
3399 nutrients-05-05127.pdf PDF - 2013 admin 18 Dec, 2013 21:00 213.97 Kb 578
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