Vitamin D and Incidence of Prediabetes or Type 2 Diabetes: A Four-Year Follow-Up Community-Based Study
Disease Markers, Vol 2018, Article ID 1926308, 8 pages, https://doi.org/10.1155/2018/1926308
Yun Gao,1 Tianpeng Zheng,2 Xingwu Ran,1 Yan Ren,1 Tao Chen,1 Li Zhong,3 Donge Yan,4 Fangfang Yan,1 Qianlin Wu,1 and Haoming Tian1
Measured Vitamin D blood levels in non-diabetics (average age 45)
4 years later
|Vitamin D Level||Prediabetes occurance|
|5.58 – 13.42 ng/ml||49% |
|16 % |
|13.43 – 16.04 ng/ml|
|16.05 – 18.55 ng/ml|
|18.56 – 32.12 ng/ml||1||1|
- Diabetes less likely 12 years later with Vitamin D – 50X if 30 ng of Vitamin D and intense exercise, 5X if 50 ng – April 2018
- Reasons to suspect Diabetes is related to low vitamin D – Jan 2018
- Omega-3 might manage T2 Diabetes – March 2018
- Zinc cut in half the rate of prediabetes progressing to diabetes (20 mg) – RCT Oct 2017
- Type 1 Diabetes (T1DM) 1.6 X more likely if low vitamin D – meta-analysis Jan 2018
- Diabetes treated and prevented by more than 2,000 IU of vitamin D (need more and gut-friendly) - meta-analyses 2018
- Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017
- Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017
Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on
- All items in category Diabetes and Vitamin D
375 items: both Type 1 and Type 2
Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
which are just some of the vitamin D cofactors
Diabetes category starts with the following
375 items In Diabetes category Autoimmune category listing has 115 items along with related searches
Aim. To examine whether the baseline 25-hydroxyvitamin D [25(OH)D] level was predictive of the onset of prediabetes or type 2 diabetes (T2DM) in the Chinese population.
Methods. This was a 4-year follow-up study that was conducted in the Chengdu region of China as part of the China National Diabetes and Metabolic Disorders Study. The study included 490 participants that were free of prediabetes and type 2 diabetes mellitus (T2DM) at baseline and had complete data by follow-up examinations. Glucose, insulin, and 25(OH)D levels were measured at baseline and at 4 years later. Prediabetes and T2DM were defined by results obtained from an oral glucose tolerance test.
Results. Over a 4-year follow-up, 95 (48.5‰) developed prediabetes and 31 (15.8‰) individuals developed diabetes. Low 25(OH)D status was significantly associated with the risk of developing prediabetes [OR 3.01 (95% CI: 1.50–6.06), ] and T2DM [OR 5.61 (95% CI: 1.73–18.27), ] after adjustment for multiple potential confounders. In a multiple linear regression analysis, low baseline levels of 25(OH)D were an independent predictor of increased insulin resistance over a 4-year period ().
Conclusions. The current prospective study suggests that low 25(OH)D levels might have contributed to the incidence of prediabetes or T2DM in Chinese individuals.
This trial is registered with TR-CCH-ChiCTR-OCS-09000361.