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Diabetes not prevented by Vitamin D (when you ignore how much vitamin D was taken) – Sept 2015

Effect of vitamin D supplementation on insulin resistance and glycaemic control in prediabetes: a systematic review and meta-analysis

N. Poolsup1, N. Suksomboon2,* andN. Plordplong2
Diabetic Medicine, DOI: 10.1111/dme.12893

Aims
To evaluate the effect of vitamin D on insulin resistance and glycaemic control in prediabetes.

Methods
A literature search was conducted of MEDLINE, the Cochrane Library, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, Web of Science and www.clinicaltrials.gov, together with a historical search through the reference lists of relevant articles until end of June 2014. Studies were included if they were randomized controlled trials of vitamin D or vitamin D analogues in prediabetes and if they reported homeostatic model assessment of insulin resistance or 2-h plasma glucose after oral glucose tolerance test. Treatment effect was estimated according to mean difference in the changes from baseline of homeostatic model assessment of insulin resistance, 2-h oral glucose tolerance test plasma glucose, fasting plasma glucose and HbA1c between vitamin D and control groups. Meta-analysis of eligible studies was performed.

Results
A total of 10 randomized controlled trials were included. Vitamin D did not significantly improve homeostatic model assessment of insulin resistance and 2-h oral glucose tolerance test plasma glucose: the mean differences were -0.06 (95% CI -0.36 to 0.24) and -0.23 mmol/l (95% CI -0.65 to 0.19), respectively. Subgroup analysis suggested that vitamin D improved homeostatic model assessment of insulin resistance in a subgroup with baseline 25-hydroxyvitamin D ≥ 50 nmol/l [mean difference -0.59 (95% CI -1.14 to -0.04); P=0.03] and improved 2-h oral glucose tolerance test plasma glucose in the subgroup with baseline 25-hydroxyvitamin D < 50 nmol/l [mean difference -0.68 mmol/l (95% CI -1.35 to -0.01); P=0.05]. Vitamin D significantly reduced fasting plasma glucose and HbA1c levels. The mean differences were -0.10 mmol/l (95% CI -0.18 to -0.03), P=0.006 and -1 mmol/mol (95% CI -2 to 0), P=0.008, respectively.

Conclusions
No beneficial effect of vitamin D in improving insulin resistance was identified.

Publisher wants $6 for the PDF


The above meta-analysis gave same weight to studies using tiny amounts of Vitamin D as studies which used a pharmacologically sufficient amount of Vitamin D


Another Diabetes Meta-analysis in 2016 ignored

  1. How much vitamin D was taken
  2. The total amount of vitamin D taken
  3. The increase in blood levels of vitamin D which resulted

The effect of vitamin D supplementation on glycaemic control in patients with Type 2 Diabetes Mellitus: a systematic review and meta-analysis
 Download the PDF from VitaminDWiki


See also VitaminDWiki

The Meta-analysis of Diabetes and Vitamin D are listed here:

Attached files

ID Name Comment Uploaded Size Downloads
6928 Diabetes meta-analysis.pdf PDF 2016 admin 03 Aug, 2016 09:51 3.31 Mb 218
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