Depression 2X more common among diabetics, both associated with low vitamin D – 2014

The Relation between Vitamin D Levels and Depression in Type 1 Diabetic Patients

Hanan M. Amer1, Manal M. AbuShady1, Rania Sayed Abdel Baky1, Hesham Fathi Khedr1, Hanan Hussien2,
Samya El-Tohamy Ismaeel3
Division of Endocrinology, Department of Internal medicine. Faculty of Medicine, Ain Shams University. Cairo, Egypt.
Neuropsychiatry department, Faculty of Medicine, Ain Shams University. Cairo, Egypt.
Biochemistry department, Faculty of Medicine, Ain Shams University. Cairo, Egypt.

Background and Aims: Recently, studies suggest vitamin D deficiency may be correlated with severity and frequency of type 1 diabetes (T1D) and depression.
Prevalence of depression in diabetics is 2-3 times higher compared to non-diabetics.
We aimed to assess vitamin D status in T1D patients and patients with depression, and its relation to diabetes control.

Methods: This study was conducted in the summer of 2013, on 120 subjects, divided into 4 groups: 30 healthy controls, 30 patients with T1D, 30 with depression and 30 with both T1D and depression. MADRS scale was used for diagnosis of depression. Serum 25-hydroxyvitamin D, FBS, 2hPG, and HbA1c were measured.

Results: Vitamin D levels were found insufficient in the control group while being deficient in all patients (62.43+ 24.86 vs.23.37 + 18.14,16.35 + 12.58, 22.14 + 20.6 nmol/L respectively, p<0.001), but without significant difference between patient groups.
Vitamin D was negatively correlated with FBS, 2hPG, HbA1c and MADRS score and positively correlated with weight and BMI.
Depression, female gender and T1D were independent determinants for vitamin D level by multiple regression analysis.

Conclusion: Vitamin D status should be assessed in diabetics and in depression. Severe depression associated with poor control.

Introduction
Diabetes mellitus (DM) is one of the most common non-communicable diseases globally. It is the fourth or fifth leading cause of death in most high-income countries and there is substantial evidence that it is epidemic in many economically developing and newly industrialized countries. Diabetes is undoubtedly one of the most challenging health problems in the 21st century 1.
Vitamin D deficiency is an important public health problem because of its great impact on bone metabolism and the possible implication on cardiovascular outcomes, diabetes, cancer and mortality 2.It was shown that vitamin D levels are suboptimal in adolescents and adults in many countries, especially in the Middle East and Asia where vitamin D deficiency appears to be highly prevalent 3. Better understanding of the physiological role of vitamin D system, in particular its potential effect on inflammatory and autoimmune conditions as well as on insulin secretion

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See also VitaminDWiki

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• Hypothesis non-severe depression and diabetes related by low vitamin D – June 2011
• Diseases that may be related via low vitamin D
• Overview Diabetes and vitamin D contains the following summary
• Diabetes is 5X more frequent far from the equator
• Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
• Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
• Sedentary people get less sun / Vitamin D
• Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
• Elderly get 4X less vitamin D from the same amount of sun
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• All items in category Diabetes and Vitamin D 537 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

• Appears that >2,000 IU will Prevent
• Appears that >4,000 IU will Treat , but not cure
• 90% less T2 Diabetes in the group having lots of Vitamin D
• Appears that Magnesium helps both Prevention and Treatment
• Many diabetics would be better treated if Gut-Friendly Vitamin D were used

Number of articles in both categories of Diabetes and:
'This list is automatically updated''

• Dark Skin 24;   Intervention 56;   Meta-analysis 38;   Obesity 35;  Pregnancy 44;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 24;  Genetics 12;  Magnesium 27    Click here to see details

Some Diabetes studies

• Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
• Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
• Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
• Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
• T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
• Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT Aug 2021

50 ng of Vitamin D fights Diabetes

• Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
• Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018

T1 Diabetes

• T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
• Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
• Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019

Pre-Diabetes

• 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
• Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
• Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020

Diabetes, Metabolic Syndrome and Magnesium - many studies
Items in both categories Diabetes and Deproession are listed here: