Depression

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Depression Overview

245 items in Depression category

See also in VitaminDWiki

• Depression substantially reduced by Vitamin D, Omega-3, Magnesium, etc – many studies
• Battling the winter blues with vitamin D (4000 IU) Dec 2015
• Seasonal Affective Disorder treatments include vitamin D and bright light – review Dec 2015
• Bipolar category in VitaminDWiki has 15 items
• Search for SAD or "seasonal Affective Disorder" 304 items not in PDF as of Dec 2019
• Note: Many people are becoming aware the increased Vitamin D = decreased Depression
  Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014

Anxiety studies include
8 VitaminDWiki pages with ANXIETY in title
This list is automatically updated

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6X increase in Vitamin D and Depression studies in a decade

PubMed indicates that Depression & "Vitamin D" is becoming very popular:

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Depression Vitamin D trials are being cancelled - too many were taking Vitamin D

Vitamin D depression RCT canceled: too many were taking Vitamin D supplements, etc. Feb 2018

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A decade of use of antidepressive drugs doubles CVD - Oct 2022

Long-term antidepressant use tied to an increase in CVD, mortality risk MDEdge

• " 10-year data from the UK Biobank on over 220,000 adults "
• "The main culprits were mirtazapine, venlafaxine, duloxetine, and trazodone, although SSRIs were also tied to increased risk"

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Depression and Vitamin D on the web

• Depression and Vitamin D: A Peculiar Relationship - April 2022 good overview PDF
• Efficacy of vitamin D in the treatment of depression: a systematic review and meta-analysis - 2021 PDF
• Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety - June 2022 PDF
  • Magnesium: The Safe First Line of Defense for Clinical Depression GreenMedInfo Oct 2019
• Why American Teens Are So Sad The Atlantic, April 2022 PDF
  • "The United States is experiencing an extreme teenage mental-health crisis. From 2009 to 2021, the share of American high-school students who say they feel “persistent feelings of sadness or hopelessness” rose from 26 percent to 44 percent, according to a new CDC study."
  • Reasons given: 1) Social-media use, 2) Sociality is down, 3) The world is stressful—and there is more news about the world’s stressors,4. Modern parenting strategies,
• Vitamin D and depression: mechanisms, determination and application - 2019 10.6133/apjcn.201912_28(4).0003 FREE PDF
• Antidepressants More Effective Than Placebo at Treating Acute Depression in Adults Feb 2018 review of Lancet Study
  but Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014
• Vitamins for Depression Psych Central Sept 2019
  • Vitamin D, SAM-e, Omega-3, St. John’s Wort, Vitamin B, Kava Kava, Probiotic, Tumeric, etc
• F.D.A. Approves First Drug for Postpartum Depression New York Times March 2019
  • "The medication works quickly, within 48 hours. But it’s an expensive infusion and requires a stay in a medical center."
• 60 hours of infusion >$20,000 for just the drug. Was found to be only better than a placebo
• Veterans Agency to Offer New Depression Drug, Despite Cost and Safety Concerns NYT June 2019__
  • $5,000 for a full course of treatment. Spravato is a nasal-spray used twice a week for 4 weeks. Generic spay costs less than $100 for a full treatment
  • "F.D.A. approval requires that people taking Spravato be monitored in a doctor’s office for at least two hours, and their experience entered in a registry"

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Antidepressant drugs often not effective and hard to stop using - Oct 2022

How to make better use of antidepressants - The Economist

• Antidepressant "drugs had a substantial effect on depression beyond that of a placebo for only 15% of patients."
• "A study published in 2010, which examined research on two common ssris, estimated that for people with less severe depression the odds of improving by taking the drugs were just 6% higher than they were for taking a placebo. "
• "A review of the research published on that topic, carried out in 2019, found that between 27% and 86% of people attempting to come off antidepressants experienced withdrawal symptoms, and that nearly half of them described those symptoms as severe."

 Download the PDF from VitaminDWiki

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Depression on the web other than Vitamin D

• Rhodiola (Tibetan Ginseng) GreenMedInfo updated Oct 2019
  • As good as Zoloft with 1/2 the side affects. Many other health benefits as well
• Exericse treats Depression Aug 2019, Dr. Patrick - mentions too - such as Omega-3 and bright light Associated Video
• Groundbreaking Study Finds Turmeric Extract Superior to Prozac for Depression Green Med Info July 2013
  6 week randomized controlled trial - virtually the same result
• Curcumin Has Antidepressive Effects in Thai Patients with Major Depression Jan 2018
  Improved benefit of conventional depression drugs about 2X
  PDF is at SicHub http://sci-hub.tw/10.1007/s12640-017-9860-4
• Curcumin in depressive disorders: An overview of potential mechanisms, preclinical and clinical findings Aug 2016
  Behind a paywall https://doi.org/10.1016/j.ejphar.2016.05.026
• Use of Antidepressants Continue to Rise Mercola Sept 2017
  "According to the World Health Organization depression is now the leading cause of ill health and disability worldwide,
  Globally, rates of depression increased by 18 % between 2005 and 2015"
  "11 % of Americans over the age of 12 are on antidepressant drugs. Among women in their 40 and 50s, 1 in 4 is on antidepressants"
  "Depression is also strongly linked to an increased risk for substance abuse, diseases such as diabetes and heart disease, and suicide."
  "Placebo Effect Accounts for 82 Percent of Drug Response"
  Describes the benefits of Vitamin D / Sun exposure. Omega-3, B vitamins, St. John's Wort , etc.
• Why Resetting Your Inner Clock Can Improve Your Life Jan 2018 Self-Hacked
  Reduce depression by Bright Light Therapy etc to deal with Season Affective Disorder, Bipolar, Delayed Sleep Phase Disorder, etc.
• CureZone about 20 people describing what cured them from being depressed Jan 2018
  Did not notice Vitamin D. Did notice Iodine
• Many People Taking Antidepressants Discover They Cannot Quit NYT April 2018
  Some 15.5 million Americans have been taking the medications for at least five years.
  The rate has almost doubled since 2010, and more than tripled since 2000.
  
• WARNING: Synthetic antidepressants raise the risk of premature death, study reveals July 2018
  "Out of 375,000 study participants on antidepressants, one-third died prematurely"
  The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis - Oct 2017, https://doi.org/10.1159/000477940
  "AD use increased the risks of mortality (HR = 1.33)"
• https://onlinelibrary.wiley.com/doi/10.1002/da.22818 Aug 2018
  Depressed mothers ==> stressed children, PDF is available free at Sci-Hub   10.1002/da.22818
  No mention that vitamin D, Mg, Omega-3 could reduce depression in mother and reduce stress/immune problem in child
• Antidepressants Cause Severe Withdrawal Symptoms like "Hallucination," "Mania," & "Anxiety," New Study Reveals GreenMed Info Oct 2018
  " More than half (56%) of people who attempt to come off antidepressants experience withdrawal effects. "
  "Nearly half (46%) of people experiencing withdrawal effects describe them as severe. "
  " It is not uncommon for the withdrawal effects to last for several weeks or months. "

Mercola and depression

• 27% of adults are depressed or anxious] Mercola 2022 PDF
• The Chemical Imbalance Myth and Antidepressant Harm Mercola Sept 2019
  • Peter C. Gøtzsche, a Danish physician-researcher, Gøtzsche helped found the Cochrane Collaboration in 1993
  • Wrote: "Deadly Medicines and Organized Crime: How Big Pharma Has Corrupted Healthcare - 2013
  • Wrote "Survival in an Overmedicated World: Look Up the Evidence Yourself" 2019
  • all of the 22 (depression) papers came to the conclusion that "the drugs were not beneficial in the long term."
• Mercola 2018 Intro to Depression, with links to details has some on Vitamin D
• Mercola June 2019
  "7% of the (US) adult population, experienced at least one major depressive episode in 2017."
  "...World Health Organization, depression is the leading cause of ill health and disability worldwide, and increased 18% between 2005 and 2015"
  "...Among seniors over the age of 65, only 14.3% met the criteria (major depressive episode)
  "Studies comparing the drugs to placebo found 20 to 40 out of 100 found relief from placebo alone, while 40 to 60 out of 100 reported improvement on an antidepressant after six to eight weeks"

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VitaminDWiki - 29 studies in both categories Depression and Omega-3

This list is automatically updated

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8 VitaminDWiki pages with ANXIETY in title

This list is automatically updated

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All items in Depression category

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All items associated with Depression

Summary as of Oct 2022
Omega-3 29; Top news 22; Cognitive 21; Pregnancy 20; Intervention 17; Meta-analysis 15; Magnesium 14; Diabetes 10; Seniors 10; Stroke. 9; Intervention - non daily. 8; Youth 8; etc.