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Depression decreased after vitamin D (50,000 IU weekly to elderly in the case) – RCT Oct 2019


Effect of vitamin D supplementation on depression in elderly patients: A randomized clinical trial

Negin Masoudi Alavia, Saeed Khademalhoseinia,∗, Saeed Khademalhosein Saeed Khademalhoseini, Zarichehr Vakilib, Fatemeh Assarianc
Clinical Nutrition DOI: https://doi.org/10.1016/j.clnu.2018.09.011 |

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Background & aims
Treatment of depression in elderly population is a crucial issue. The effect of vitamin D supplementation on treatment of depression in older adults was investigated in this clinical trial.

Methods
It was an 8-week, randomized clinical trial of vitamin D supplementation and placebo in the treatment of depression in 3 psychiatric clinics. The study sample included 78 older adults aged over 60 years with moderate to severe depression. Subjects were randomly allocated to receive 50,000 U vitamin D3 pearl weekly for 8 weeks or placebo (39 subjects in each group). Main outcome measures comprised Geriatric Depression Scale-15 (GDS-15) questionnaire and 25-hydroxyvitamin D3 [25(OH)D3]. The analysis utilized Mann Whitney U test, Wilcoxon signed ranks test, chi-square and multiple regression analysis.

Results
The mean baseline 25(OH)D3 concentration was 22.57 ± 6.2 ng/ml in vitamin D group and 21.2 ± 5.8 ng/ml in placebo group (p = 0.16). The Vitamin D increased to 43.48 ± 9.5 ng/ml in vitamin D and 25.9 ± 15.3 ng/ml in placebo group. The depression score decreased from 9.25 to 7.48 in vitamin D group (p = 0.0001), while there was a non-significant increase in depression score in placebo group. The multiple regression analysis showed that the vitamin D group and the score of depression before study were the variables that could explain 81.8% of depression score after intervention.

Conclusion
The findings indicated that vitamin D supplementation can improve the depression score in persons aged 60 and over.
 Download the PDF from Sci-Hub via VitaminDWiki


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Created by admin. Last Modification: Monday August 21, 2023 12:28:30 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
19986 depression 50K table.jpg admin 21 Aug, 2023 25.76 Kb 61
12811 Depression.pdf admin 17 Oct, 2019 376.95 Kb 823