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Depressed adults with low vitamin D - decrease in depression associated with increase in vitamin D – Oct 2018

Change in serum 25-hydroxyvitamin D and parallel change in depressive symptoms in Dutch older adults

Eur J Endocrinol. 2018 Oct 1;179(4):239-249. doi: 10.1530/EJE-18-0187.
Elstgeest LEM, de Koning EJ, Brouwer IA, van Schoor NM, Penninx BWJH, Visser M.


Pages listed in BOTH the categories Intervention AND Depression

Pages listed in BOTH the categories Depression and Meta-analysis

PDF is available free at Sci-Hub   10.1530/EJE-18-0187

Previous prospective studies on the association between vitamin D status and depression used a single 25-hydroxyvitamin D (25(OH)D) measurement. We investigated the association between change in serum 25(OH)D and parallel change in depressive symptoms over time in Dutch older adults.

DESIGN: A population-based, prospective study in two cohorts of older men and women from the Longitudinal Aging Study Amsterdam.

Serum 25(OH)D concentrations were determined at two time points: in 1995/1996 and 13 years later in the older cohort (aged 65–88y, n = 173) and in 2002/2003 and 6 years later in the younger cohort (55–65 years, n = 450). At these time points, depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale (CES-D). Associations were tested by multiple linear regression analyses.

During follow-up, serum 25(OH)D concentrations increased in 32.4% of the older cohort and in 69.8% of the younger cohort. In the older cohort, change in 25(OH)D was not associated with change in CES-D score. In the younger cohort, no associations were observed in participants with higher baseline 25(OH)D concentrations (>58.6 nmol/L), but in those with lower baseline 25(OH)D concentrations, an increase in 25(OH)D was associated with a decrease in CES-D score (adjusted B per 10 nmol/L 25(OH)D increase: −0.62 (95% CI: −1.17, −0.07)).

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